The DOI matches its Crossref record; 51 of the 51 references it cites were found in a registry or an index.
Ethnic Differences in Maternal Thyroid Parameters during Pregnancy: The Generation R Study
Abstract
CONTEXT: Abnormal maternal thyroid function during pregnancy is associated with various complications. International guidelines advocate the use of population-based trimester-specific reference ranges for thyroid function tests. When unavailable, an upper TSH limit of 2.5 for the first trimester and 3.0 mU/L for the second and third trimesters is recommended. Although interindividual differences in thyroid function tests can partially be explained by ethnicity, data on the influence of ethnicity on TSH and free T4 reference ranges during pregnancy are sparse. DESIGN: Serum TSH, free T4, T4, and TPO-antibody levels were determined during early pregnancy in 3944 women from the Generation R study, Rotterdam, The Netherlands. RESULTS: The study population consisted of 2765 Dutch, 308 Moroccan, 421 Turkish, and 450 Surinamese women. Mean TSH levels were higher in Dutch and Turkish women than in Moroccan or Surinamese women (1.50-1.48 vs 1.29-1.33 mU/L; P < .01). Although no differences in free T4 were seen, T4 was lowest in Dutch women (142 vs 150-156 nmol/L; P < .01). Turkish women had the highest frequency of TPO-antibody positivity (9.3% vs 5.0-5.8%; P < .05) and of elevated TSH levels in the second trimester (11.0% vs 3.8-7.3%; P < .01). A comparison of disease prevalence between a population-based vs an ethnicity-specific reference range changed the diagnosis for 18% of women who were initially found to have abnormal thyroid function test results. CONCLUSIONS: We show ethnic differences in serum TSH, T4, and TPO-antibody positivity and found significant diagnostic discrepancies depending on whether population or ethnicity-specific reference ranges were used to diagnose thyroid disease.
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“Although the effect is modest, misclassification of abnormal thyroid function or restoration to euthyroidism can occur when stricter targets are used in pregnancy.21”
From Hypothyroidism (2024) · cites this paper as [21]
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Cites
Hollowell, J. G., Staehling, N. W., Flanders, W. D., Hannon, W. H., Gunter, E. W., Spencer, C. A., & Braverman, L. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.87.2.489 · Cited by 4,279
Stagnaro-Green, A., Abalovich, M., Alexander, E., Azizi, F., Mestman, J., Negro, R., Nixon, A., Pearce, E. N., Soldin, O. P., Sullivan, S., et al. (2011) · Thyroid · doi:10.1089/thy.2011.0087 · Cited by 2,942
DeGroot, L. J., Abalovich, M., Alexander, E. K., Amino, N., Barbour, L. A., Cobin, R. H., Eastman, C. J., Lazarus, J. H., Luton, D., Mandel, S. J., et al. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-2803 · Cited by 1,885
The Generation R Study: design and cohort update 2017
Kooijman, M. N., Kruithof, C. J., van Duijn, C. M., Duijts, L., Franco, O. H., van IJzendoorn, M. H., de Jongste, J. C., Klaver, C. C. W., van der Lugt, A., Mackenbach, J. P., et al. (2016) · European Journal of Epidemiology · doi:10.1007/s10654-016-0224-9 · Cited by 1,238
The Generation R Study: design and cohort update 2010
Jaddoe, V. W. V., van Duijn, C. M., van der Heijden, A. J., Mackenbach, J. P., Moll, H. A., Steegers, E. A. P., Tiemeier, H., Uitterlinden, A. G., Verhulst, F. C., & Hofman, A. (2010) · European Journal of Epidemiology · doi:10.1007/s10654-010-9516-7 · Cited by 1,027
Self-citationAbalovich, M., Amino, N., Barbour, L. A., Cobin, R. H., DeGroot, L. J., Glinoer, D., Mandel, S. J., & Stagnaro‐Green, A. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-0141 · Cited by 934
Thangaratinam, S., Tan, A., Knox, E., Kilby, M. D., Franklyn, J., & Coomarasamy, A. (2011) · BMJ · doi:10.1136/bmj.d2616 · Cited by 604
The Generation R Study: Design and cohort update 2012
Jaddoe, V. W. V., van Duijn, C. M., Franco, O. H., van der Heijden, A. J., van IIzendoorn, M. H., de Jongste, J. C., van der Lugt, A., Mackenbach, J. P., Moll, H. A., Raat, H., et al. (2012) · European Journal of Epidemiology · doi:10.1007/s10654-012-9735-1 · Cited by 546
van den Boogaard, E., Vissenberg, R., Land, J. A., van Wely, M., van der Post, J. A. M., Goddijn, M., & Bisschop, P. H. (2011) · Human Reproduction Update · doi:10.1093/humupd/dmr024 · Cited by 528
Negro, R., Schwartz, A., Gismondi, R., Tinelli, A., Mangieri, T., & Stagnaro‐Green, A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-0340 · Cited by 440
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Jonklaas, J., Bianco, A. C., Bauer, A. J., Burman, K. D., Cappola, A. R., Celi, F. S., Cooper, D. S., Kim, B. W., Peeters, R. P., Rosenthal, M. S., et al. (2014) · Thyroid® · doi:10.1089/thy.2014.0028 · Cited by 1,928
Lazarus, J., Brown, R. S., Daumerie, C., Hubalewska-Dydejczyk, A., Negro, R., & Vaidya, B. (2014) · European Thyroid Journal · doi:10.1159/000362597 · Cited by 742
Influence of maternal thyroid hormones during gestation on fetal brain development
Moog, N. K., Entringer, S., Heim, C. C., Wadhwa, P. D., Kathmann, N., & Buß, C. (2015) · Neuroscience · doi:10.1016/j.neuroscience.2015.09.070 · Cited by 497
“…iodine-deficient regions (Pharoah et al., 1984, Costeira et al., 2011), one study only includes children born preterm (Williams et al., 2012) and there also are large differences in ethnicity across studies, which is a source of variability of TH levels (Aoki et al., 2007, Korevaar et al., 2013).”
BackgroundKorevaar, T. I. M., Schalekamp–Timmermans, S., de Rijke, Y. B., Visser, W. E., Visser, W. E., Keizer‐Schrama, S. M. P. F. D. M., Albert Hofman, D., Ross, H. A., Hooijkaas, H., Tiemeier, H. W., et al. (2013) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2013-2855 · Cited by 263
The Generation R Study: Biobank update 2015
Kruithof, C. J., Kooijman, M. N., van Duijn, C. M., Franco, O. H., de Jongste, J. C., Klaver, C. C. W., Mackenbach, J. P., Moll, H. A., Raat, H., Rings, E. H. H. M., et al. (2014) · European Journal of Epidemiology · doi:10.1007/s10654-014-9980-6 · Cited by 225
Metadata
- Authors
- Korevaar, T. I. M., Medici, M., de Rijke, Y. B., Visser, W., de Muinck Keizer-Schrama, S. M. P. F., Jaddoe, V. W. V., Hofman, A., Ross, H. A., Visser, W. E., Hooijkaas, H., Steegers, E. A. P., Tiemeier, H., Bongers-Schokking, J. J., Visser, T. J., & Peeters, R. P.
- Affiliations
- Erasmus MC (NL)
- Radboud University Nijmegen (NL)
- Corresponding author
- Peeters, Robin P.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2013-09
- Volume
- 98
- Issue
- 9
- Pages
- 3678-3686
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2133831600
- Cited by
- 150
- References
- 51
- Citations by year
- 2026: 4 · 2025: 3 · 2024: 2 · 2023: 37 · 2022: 17 · 2021: 9 · 2020: 7 · 2019: 13 · 2018: 10 · 2017: 17 · 2016: 9 · 2015: 8 · 2014: 11 · 2013: 2
- FWCI
- 7.84
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- EUR Research Repository (Erasmus University Rotterdam) (submittedVersion)
- Radboud Repository (Radboud University) (submittedVersion)
- Funders
- Erasmus Universiteit Rotterdam
- Erasmus Medisch Centrum
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Health Professions › Medical Laboratory Technology › Clinical Laboratory Practices and Quality Control
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Keywords
- maternal thyroid function, pregnancy, ethnic differences, thyroid-stimulating hormone, free thyroxine, total thyroxine, thyroid peroxidase antibodies, thyroid autoimmunity, thyroid disease diagnosis, Generation R Study
- MeSH terms
- Adult, Female, Humans, Iodide Peroxidase, Netherlands, Pregnancy, Pregnancy Complications, Reference Values, Thyroid Diseases, Thyroid Function Tests, Thyrotropin, Thyroxine, Triiodothyronine, Prevalence
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