The DOI matches its Crossref record; 33 of the 33 references it cites were found in a registry or an index.
Reference Intervals for Insulin-like Growth Factor-1 (IGF-I) From Birth to Senescence: Results From a Multicenter Study Using a New Automated Chemiluminescence IGF-I Immunoassay Conforming to Recent International Recommendations
Open accessAbstract
CONTEXT: Measurement of IGF-I is a cornerstone in diagnosis and monitoring of GH-related diseases, but considerable discrepancies exist between analytical methods. A recent consensus conference defined criteria for validation of IGF-I assays and for establishment of normative data. OBJECTIVES: Our objectives were development and validation of a novel automated IGF-I immunoassay (iSYS; Immunodiagnostic Systems) according to international guidelines and establishment of method-specific age- and sex-adjusted reference intervals and analysis of their robustness. SETTING AND PARTICIPANTS: We conducted a multicenter study with samples from 12 cohorts from the United States, Canada, and Europe including 15 014 subjects (6697 males and 8317 females, 0-94 years of age). MAIN OUTCOME MEASURES: We measured concentrations of IGF-I as determined by the IDS iSYS IGF-I assay. RESULTS: A new IGF-I assay calibrated against the recommended standard (02/254) and insensitive to the 6 high-affinity IGF binding proteins was developed and rigorously validated. Age- and sex-adjusted reference intervals derived from a uniquely large cohort reflect the age-related pattern of IGF-I secretion: a decline immediately after birth followed by an increase until a pubertal peak (at 15 years of age). Later in life, values decrease continuously. The impact of gender is small, although across the lifespan, women have lower mean IGF-I concentrations. Geographical region, sampling setting (community or hospital based), and rigor of exclusion criteria in our large cohort did not affect the reference intervals. CONCLUSIONS: Using large cohorts of well-characterized subjects from different centers allowed construction of robust reference ranges for a new automated IGF-I assay. The strict adherence to recent consensus criteria for IGF-I assays might facilitate clinical application of the results.
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Self-citationGuidelines for Acromegaly Management: An Update
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Growth hormone — past, present and future
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Acromegaly: pathogenesis, diagnosis, and management
Fleseriu, M., Langlois, F., Lim, D. S. T., Varlamov, E. V., & Melmed, S. (2022) · The Lancet Diabetes & Endocrinology · doi:10.1016/s2213-8587(22)00244-3 · Cited by 279
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Metadata
- Authors
- Bidlingmaier, M., Friedrich, N., Emeny, R. T., Spranger, J., Wolthers, O. D., Roswall, J., Körner, A., Obermayer-Pietsch, B., Hübener, C., Dahlgren, J., Frystyk, J., Pfeiffer, A. F. H., Doering, A., Bielohuby, M., Wallaschofski, H., & Arafat, A. M.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2014-05-01
- Volume
- 99
- Issue
- 5
- Pages
- 1712-1721
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2087995681
- Cited by
- 400
- References
- 33
- FWCI
- 20.11
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Reference Intervals for Insulin-like Growth Factor-1 (IGF-I) From Birth to Senescence: Results From a Multicenter Study Using a New Automated Chemiluminescence IGF-I Immunoassay Conforming to Recent International Recommendations. https://app.cochat.ai/papers/10.1210/jc.2013-3059
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- Bidlingmaier, M., Friedrich, N., Emeny, R. T., Spranger, J., Wolthers, O. D., Roswall, J., Körner, A., Obermayer-Pietsch, B., Hübener, C., Dahlgren, J., Frystyk, J., Pfeiffer, A. F. H., Doering, A., Bielohuby, M., Wallaschofski, H., & Arafat, A. M. (2014). Reference Intervals for Insulin-like Growth Factor-1 (IGF-I) From Birth to Senescence: Results From a Multicenter Study Using a New Automated Chemiluminescence IGF-I Immunoassay Conforming to Recent International Recommendations. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2013-3059
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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