The DOI matches its Crossref record; 158 of the 158 references it cites were found in a registry or an index.
Growth hormone — past, present and future
Overview
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Claims the paper makes
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Claims other papers make about this one
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In the citing paper
“In children, GHD can be strongly indicated based on insulin-like growth factor I (IGF-I) concentrations, height velocity, or other auxologic features, but is often confirmed with biochemical testing.8,65,73,74”
In the citing paper
“Stimulation test thresholds ranging from <5 to <10 μg/L have been suggested as indicative of GHD in children,73,80,81 with the current consensus value listed as <10 μg/L.9”
In the citing paper
“Patients who remain GH deficient after reaching adult height can be at risk of adverse metabolic outcomes, increased fat mass and BMI, decreased bone mineralization and mineral density, and decreased QOL if GH therapy is stopped.73,76,82,121-123”
In the citing paper
“Besides holding for retesting purposes, it is recommended to continue GH therapy in patients with confirmed GHD during the transition period, even if adult height has been achieved, as treatment is associated with improved body composition, bone health, cognitive function, QOL, and lipid metabolism in adulthood.73,76,92,98,120”
In the citing paper
“Retesting is not required in patients with ≥3 pituitary hormone deficiencies and with low serum IGF-I (< -2.0 SDS), as GHD is likely in these patients.73,76,102”
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
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Citations
Cites
Ghrelin is a growth-hormone-releasing acylated peptide from stomach
Kojima, M., Hosoda, H., Date, Y., Nakazato, M., Matsuo, H., & Kangawa, K. (1999) · Nature · doi:10.1038/45230 · Cited by 8,479
Prusiner, S. B. (1998) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.95.23.13363 · Cited by 5,373
Kirk, J., MacDonald, A., Lavender, P., Dean, J., & Rubin, G. (2017) · Biomedicine Hub · doi:10.1159/000480347 · Cited by 3,887
Hypothalamic Polypeptide That Inhibits the Secretion of Immunoreactive Pituitary Growth Hormone
Brazeau, P., Vale, W., Burgus, R., Ling, N., Butcher, M., Rivier, J., & Guillemin, R. (1973) · Science · doi:10.1126/science.179.4068.77 · Cited by 3,532
Adverse drug reactions: definitions, diagnosis, and management
Edwards, I. R., & Aronson, J. K. (2000) · The Lancet · doi:10.1016/s0140-6736(00)02799-9 · Cited by 2,979
Role of insulin-like growth factors in embryonic and postnatal growth
Baker, J., Liu, J.-P., Robertson, E. J., & Efstratiadis, A. (1993) · Cell · doi:10.1016/s0092-8674(05)80085-6 · Cited by 2,463
Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex
de Vos, A. M., Ultsch, M., & Kossiakoff, A. A. (1992) · Science · doi:10.1126/science.1549776 · Cited by 2,239
A Receptor in Pituitary and Hypothalamus That Functions in Growth Hormone Release
Howard, A. D., Feighner, S. D., Cully, D. F., Arena, J. P., Liberator, P. A., Rosenblum, C. I., Hamelin, M., Hreniuk, D. L., Palyha, O. C., Anderson, J., et al. (1996) · Science · doi:10.1126/science.273.5277.974 · Cited by 2,073
Production of recombinant protein therapeutics in cultivated mammalian cells
Wurm, F. M. (2004) · Nature Biotechnology · doi:10.1038/nbt1026 · Cited by 2,032
Cellular Actions of the Insulin-Like Growth Factor Binding Proteins
Firth, S. M., & Baxter, R. C. (2002) · Endocrine Reviews · doi:10.1210/er.2001-0033 · Cited by 1,750
Cited by
An evolutionary perspective on immunometabolism
Wang, A., Luan, H. H., & Medzhitov, R. (2019) · Science · doi:10.1126/science.aar3932 · Cited by 389
Safety and efficacy of pediatric growth hormone therapy: results from the full KIGS cohort
Maghnie, M., Ranke, M. B., Geffner, M. E., Vlachopapadopoulou, E., Ibáñez, L., Carlsson, M., Cutfield, W., Rooman, R., Gomez, R., Wajnrajch, M. P., et al. (2022) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgac517 · Cited by 120
Self-citationWexler, T. L., Reifschneider, K., Backeljauw, P., Cárdenas, J. F., Hoffman, A. R., Miller, B. S., & Yuen, K. C. J. (2023) · Journal of Neurotrauma · doi:10.1089/neu.2022.0384 · Cited by 19
Backeljauw, P., Kanumakala, S., Loche, S., Schwab, K. O., Pfäffle, R. W., Höybye, C., Lundberg, E., Battelino, T., Kriström, B., Giemza, T., et al. (2021) · Hormone Research in Paediatrics · doi:10.1159/000515875 · Cited by 19
Growth hormone replacement therapy in childhood-onset craniopharyngioma
van Iersel, L., van Schaik, J., & van Santen, H. M. (2025) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2025.101998 · Cited by 6
Metadata
- Authors
- Ranke, M. B., & Wit, J. M.
- Venue
- Nature Reviews Endocrinology
- Published
- 2018-03-16
- Volume
- 14
- Issue
- 5
- Pages
- 285-300
- ISSN
- 1759-5029 (ISSN-L)
- 1759-5037
- OpenAlex
- W2789677699
- Cited by
- 346
- References
- 158
- FWCI
- 6.38
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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- CoChat. (2026). Citation check: Growth hormone — past, present and future. https://app.cochat.ai/papers/10.1038/nrendo.2018.22
- The paper
- Ranke, M. B., & Wit, J. M. (2018). Growth hormone — past, present and future. Nature Reviews Endocrinology. https://doi.org/10.1038/nrendo.2018.22
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
