Cited by 221Thyroid Disorders and TreatmentsThyroid Cancer Diagnosis and TreatmentChemical Analysis and Environmental Impact

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A Review: Radiographic Iodinated Contrast Media-Induced Thyroid Dysfunction

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Lee, Sun Y., Rhee, Connie M., Leung, Angela M., Braverman, Lewis E., Brent, Gregory A., Pearce, Elizabeth N.·2015·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.2014-3292PMC PMC4318903

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Abstract

CONTEXT: Thyroid hormone production is dependent on adequate iodine intake. Excess iodine is generally well-tolerated, but thyroid dysfunction can occur in susceptible individuals after excess iodine exposure. Radiological iodinated contrast media represent an increasingly common source of excess iodine. OBJECTIVE: This review will discuss the thyroidal response after acute exposure to excess iodine; contrast iodine-induced thyroid dysfunction; risks of iodine-induced thyroid dysfunction in vulnerable populations, such as the fetus, neonate, and patients with impaired renal function; and recommendations for the assessment and treatment of contrast iodine-induced thyroid dysfunction. METHODS: Data for this review were identified by searching PubMed, Google Scholar, and references from relevant articles from 1948 to 2014. CONCLUSIONS: With the increase in the use of computed tomography scans in the United States, there is increasing risk of contrast-induced thyroid dysfunction. Patients at risk of developing iodine-induced thyroid dysfunction should be closely monitored after receiving iodinated contrast media and should be treated as needed.

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Authors: Lee, S. Y., Rhee, C. M., Leung, A. M., Braverman, L. E., Brent, G. A., & Pearce, E. N.
Affiliations: Boston University (US)
University of California, Irvine (US)
University of California, Los Angeles (US)
Corresponding author: Lee, Sun Y.
Rhee, Connie M.
ORCID: Lee, Sun Y.
Rhee, Connie M.
Leung, Angela M.
Braverman, Lewis E.
Brent, Gregory A.
Pearce, Elizabeth N.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2015-02
Volume: 100
Issue: 2
Pages: 376-383
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.2014-3292
PMC: PMC4318903
OpenAlex: W1996335887
Cited by: 221
References: 73
Citations by year: 2026: 7 · 2025: 15 · 2024: 33 · 2023: 25 · 2022: 30 · 2021: 29 · 2020: 23 · 2019: 18 · 2018: 17 · 2017: 5 · 2016: 10 · 2015: 7
FWCI: 6.43
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
eScholarship (California Digital Library) (submittedVersion, cc-by)
Funders: National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007201, K23DK102903)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD068552)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
Keywords: iodinated contrast media, thyroid hormone synthesis, iodine toxicity, computed tomography, renal dysfunction, thyroid function monitoring
MeSH terms: Contrast Media, Humans, Thyroid Diseases, Thyroid Function Tests

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A Review: Radiographic Iodinated Contrast Media-Induced Thyroid Dysfunction

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