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A Review: Radiographic Iodinated Contrast Media-Induced Thyroid Dysfunction
Open accessAbstract
CONTEXT: Thyroid hormone production is dependent on adequate iodine intake. Excess iodine is generally well-tolerated, but thyroid dysfunction can occur in susceptible individuals after excess iodine exposure. Radiological iodinated contrast media represent an increasingly common source of excess iodine. OBJECTIVE: This review will discuss the thyroidal response after acute exposure to excess iodine; contrast iodine-induced thyroid dysfunction; risks of iodine-induced thyroid dysfunction in vulnerable populations, such as the fetus, neonate, and patients with impaired renal function; and recommendations for the assessment and treatment of contrast iodine-induced thyroid dysfunction. METHODS: Data for this review were identified by searching PubMed, Google Scholar, and references from relevant articles from 1948 to 2014. CONCLUSIONS: With the increase in the use of computed tomography scans in the United States, there is increasing risk of contrast-induced thyroid dysfunction. Patients at risk of developing iodine-induced thyroid dysfunction should be closely monitored after receiving iodinated contrast media and should be treated as needed.
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“Individuals who are the most susceptible are elderly patients with autonomously functioning nodular goiters (557) and, less commonly, patients with occult GD (558) or patients with a prior history of GD who are in remission after a course of ATDs (559).”
From 2016 American Thyroid Association Guidelines for Diagnosis and Management of Hyperthyroidism and Other Causes of Thyrotoxicosis (2016) · cites this paper as [558]
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“Individuals who are the most susceptible are elderly patients with autonomously functioning nodular goiters (557) and, less commonly, patients with occult GD (558) or patients with a prior history of GD who are in remission after a course of ATDs (559).”
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Metadata
- Authors
- Lee, S. Y., Rhee, C. M., Leung, A. M., Braverman, L. E., Brent, G. A., & Pearce, E. N.
- Affiliations
- Boston University (US)
- University of California, Irvine (US)
- University of California, Los Angeles (US)
- Corresponding author
- Lee, Sun Y.
- Rhee, Connie M.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2015-02
- Volume
- 100
- Issue
- 2
- Pages
- 376-383
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- PMC
- PMC4318903
- OpenAlex
- W1996335887
- Cited by
- 221
- References
- 73
- Citations by year
- 2026: 7 · 2025: 15 · 2024: 33 · 2023: 25 · 2022: 30 · 2021: 29 · 2020: 23 · 2019: 18 · 2018: 17 · 2017: 5 · 2016: 10 · 2015: 7
- FWCI
- 6.43
- Type
- journal article
- Language
- en
- Open access
- green
- www.ncbi.nlm.nih.gov
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- eScholarship (California Digital Library) (submittedVersion, cc-by)
- Funders
- National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007201, K23DK102903)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (K23HD068552)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Cancer Diagnosis and Treatment
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Chemical Analysis and Environmental Impact
- Keywords
- iodinated contrast media, thyroid hormone synthesis, iodine toxicity, computed tomography, renal dysfunction, thyroid function monitoring
- MeSH terms
- Contrast Media, Humans, Thyroid Diseases, Thyroid Function Tests
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