The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Male Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union
Open accessAbstract
INTRODUCTION: Increasing evidence suggests that endocrine-disrupting chemicals (EDCs) contribute to male reproductive diseases and disorders. PURPOSE: To estimate the incidence/prevalence of selected male reproductive disorders/diseases and associated economic costs that can be reasonably attributed to specific EDC exposures in the European Union (EU). METHODS: An expert panel evaluated evidence for probability of causation using the Intergovernmental Panel on Climate Change weight-of-evidence characterization. Exposure-response relationships and reference levels were evaluated, and biomarker data were organized from carefully identified studies from the peer-reviewed literature to represent European exposure and approximate burden of disease as it occurred in 2010. The cost-of-illness estimation utilized multiple peer-reviewed sources. RESULTS: The expert panel identified low epidemiological and strong toxicological evidence for male infertility attributable to phthalate exposure, with a 40-69% probability of causing 618,000 additional assisted reproductive technology procedures, costing €4.71 billion annually. Low epidemiological and strong toxicological evidence was also identified for cryptorchidism due to prenatal polybrominated diphenyl ether exposure, resulting in a 40-69% probability that 4615 cases result, at a cost of €130 million (sensitivity analysis, €117-130 million). A much more modest (0-19%) probability of causation in testicular cancer by polybrominated diphenyl ethers was identified due to very low epidemiological and weak toxicological evidence, with 6830 potential cases annually and costs of €848 million annually (sensitivity analysis, €313-848 million). The panel assigned 40-69% probability of lower T concentrations in 55- to 64-year-old men due to phthalate exposure, with 24 800 associated deaths annually and lost economic productivity of €7.96 billion. CONCLUSIONS: EDCs may contribute substantially to male reproductive disorders and diseases, with nearly €15 billion annual associated costs in the EU. These estimates represent only a few EDCs for which there were sufficient epidemiological studies and those with the highest probability of causation. These public health costs should be considered as the EU contemplates regulatory action on EDCs.
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Citations
Cites
Grading quality of evidence and strength of recommendations
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Grading quality of evidence and strength of recommendations for diagnostic tests and strategies
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Decrease in anogenital distance among male infants with prenatal phthalate exposure
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Effect of testosterone and estradiol in a man with aromatase deficiency
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“In reviewing the toxicological data on phthalate exposure and fertility outcomes, the panel identified extensive and strong evidence that developmental exposure to several antiandrogenic phthalates affected male reproductive development, leading to a long list of adverse effects including reduced AGD, increased preval…”
Endogenous Testosterone and Mortality in Men: A Systematic Review and Meta-Analysis
Araujo, A. B., Dixon, J. M., Suarez, E. A., Murad, M. H., Guey, L. T., & Wittert, G. A. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-1137 · Cited by 671
Cited by
Temporal trends in sperm count: a systematic review and meta-regression analysis
Levine, H., Jørgensen, N., Martino-Andrade, A., Mendiola, J., Weksler-Derri, D., Mindlis, I., Pinotti, R., & Swan, S. H. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx022 · Cited by 1,374
Levine, H., Jørgensen, N., Martino-Andrade, A., Mendiola, J., Weksler-Derri, D., Jolles, M., Pinotti, R., & Swan, S. H. (2023) · Human Reproduction Update · doi:10.1093/humupd/dmac035 · Cited by 728
Barratt, C. L. R., Björndahl, L., De Jonge, C. J., Lamb, D. J., Osorio Martini, F., McLachlan, R., Oates, R. D., van der Poel, S., St John, B., Sigman, M., et al. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx021 · Cited by 505
“For example, it is estimated that the EDC may contribute substantially to male reproductive disorders and disease equivalent to a staggering €15 billion cost in the European Union (Hauser et al., 2015) although these figures are subject to considerable debate (e.g. Olsson, 2014; Woodruff, 2015).”
BackgroundInfluentialEnvironmental factors in declining human fertility
Skakkebæk, N. E., Lindahl-Jacobsen, R., Levine, H., Andersson, A.-M., Jørgensen, N., Main, K. M., Lidegaard, Ø., Priskorn, L., Holmboe, S. A., Bräuner, E. V., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00598-8 · Cited by 389
Self-citationSex determination, gonadal sex differentiation, and plasticity in vertebrate species
Nagahama, Y., Chakraborty, T., Paul-Prasanth, B., Ohta, K., & Nakamura, M. (2021) · Physiological Reviews · doi:10.1152/physrev.00044.2019 · Cited by 346
Metadata
- Authors
- Hauser, R., Skakkebaek, N. E., Hass, U., Toppari, J., Juul, A., Andersson, A. M., Kortenkamp, A., Heindel, J. J., & Trasande, L.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2015-04
- Volume
- 100
- Issue
- 4
- Pages
- 1267-1277
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W4214940459
- Cited by
- 182
- References
- 14
- FWCI
- 15.71
- Type
- journal article
- Language
- en
- Open access
- hybrid
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- Hauser, R., Skakkebaek, N. E., Hass, U., Toppari, J., Juul, A., Andersson, A. M., Kortenkamp, A., Heindel, J. J., & Trasande, L. (2015). Male Reproductive Disorders, Diseases, and Costs of Exposure to Endocrine-Disrupting Chemicals in the European Union. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.2014-4325
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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