Temporal trends in sperm count: a systematic review and meta-regression analysis of samples collected globally in the 20th and 21st centuries
Open accessAbstract
BACKGROUND: Numerous studies have reported declines in semen quality and other markers of male reproductive health. Our previous meta-analysis reported a significant decrease in sperm concentration (SC) and total sperm count (TSC) among men from North America–Europe–Australia (NEA) based on studies published during 1981–2013. At that time, there were too few studies with data from South/Central America–Asia–Africa (SAA) to reliably estimate trends among men from these continents. OBJECTIVE AND RATIONALE: The aim of this study was to examine trends in sperm count among men from all continents. The broader implications of a global decline in sperm count, the knowledge gaps left unfilled by our prior analysis and the controversies surrounding this issue warranted an up-to-date meta-analysis. SEARCH METHODS: We searched PubMed/MEDLINE and EMBASE to identify studies of human SC and TSC published during 2014–2019. After review of 2936 abstracts and 868 full articles, 44 estimates of SC and TSC from 38 studies met the protocol criteria. Data were extracted on semen parameters (SC, TSC, semen volume), collection year and covariates. Combining these new data with data from our previous meta-analysis, the current meta-analysis includes results from 223 studies, yielding 288 estimates based on semen samples collected 1973–2018. Slopes of SC and TSC were estimated as functions of sample collection year using simple linear regression as well as weighted meta-regression. The latter models were adjusted for predetermined covariates and examined for modification by fertility status (unselected by fertility versus fertile), and by two groups of continents: NEA and SAA. These analyses were repeated for data collected post-2000. Multiple sensitivity analyses were conducted to examine assumptions, including linearity. OUTCOMES: Overall, SC declined appreciably between 1973 and 2018 (slope in the simple linear model: –0.87 million/ml/year, 95% CI: –0.89 to –0.86; P < 0.001). In an adjusted meta-regression model, which included two interaction terms [time × fertility group (P = 0.012) and time × continents (P = 0.058)], declines were seen among unselected men from NEA (–1.27; –1.78 to –0.77; P < 0.001) and unselected men from SAA (–0.65; –1.29 to –0.01; P = 0.045) and fertile men from NEA (–0.50; –1.00 to –0.01; P = 0.046). Among unselected men from all continents, the mean SC declined by 51.6% between 1973 and 2018 (–1.17: –1.66 to –0.68; P < 0.001). The slope for SC among unselected men was steeper in a model restricted to post-2000 data (–1.73: –3.23 to –0.24; P = 0.024) and the percent decline per year doubled, increasing from 1.16% post-1972 to 2.64% post-2000. Results were similar for TSC, with a 62.3% overall decline among unselected men (–4.70 million/year; –6.56 to –2.83; P < 0.001) in the adjusted meta-regression model. All results changed only minimally in multiple sensitivity analyses. WIDER IMPLICATIONS: This analysis is the first to report a decline in sperm count among unselected men from South/Central America–Asia–Africa, in contrast to our previous meta-analysis that was underpowered to examine those continents. Furthermore, data suggest that this world-wide decline is continuing in the 21st century at an accelerated pace. Research on the causes of this continuing decline and actions to prevent further disruption of male reproductive health are urgently needed.
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Some evidence suggests that decreased male fertility is due to an annual decline of 1.4% in sperm concentration and 1.6% in total sperm count, although the impact on TFR is yet unknown.
“Some evidence suggests that decreased male fertility is due to an annual decline of 1.4% in sperm concentration and 1.6% in total sperm count, although the impact on TRF is yet unknown (Levine et al., 2017; Jørgensen et al., 2021; Levine et al., 2023).”
From Declining global fertility rates and the implications for family planning and family building: an IFFS consensus document based on a narrative review of the literature (2024) · cites this paper as Levine et al., 2023
The Meta-regression models for SC and TSC sections (pages unavailable) report declining sperm measures among unselected men, and Other issues links those measures to chances of conception. But the reported annual declines are 1.16% for sperm concentration and 1.40% for total sperm count—not 1.4% and 1.6%, respectively. The paper does not establish that the sperm-count decline caused decreased male fertility or assess its impact on the total fertility rate. (LLM, conf=0.91)
Experimental — accuracy not yet measuredBiological sterility in industrialized economies is increasing among both women and men due to environmental factors.
“There are strong indications that biological sterility in industrialized economies is increasing among both women and men due to environmental factors (for a survey, see Skakkebæk et al. 2022, Levine et al. 2023).”
From Fertility in High-Income Countries: Trends, Patterns, Determinants, and Consequences (2024) · cites this paper as Levine et al. 2023
The Conclusion and wider implications (page unavailable) reports declining sperm counts among men in North America, Europe and Australia, and the Introduction links sperm count to infertility. It does not establish increasing biological sterility in women or show that environmental factors caused the decline; the conclusion calls for research into its causes. (LLM, conf=0.88)
Experimental — accuracy not yet measured
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Cites
Preferred Reporting Items for Systematic Reviews and Meta-Analyses: the PRISMA statement
Moher, D., Liberati, A., Tetzlaff, J., Altman, D. G., & for the PRISMA Group (2009) · BMJ · doi:10.1136/bmj.b2535 · Cited by 83,823 · see citing works
Stroup, D. F. (2000) · JAMA · doi:10.1001/jama.283.15.2008 · Cited by 20,623 · see citing works
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gotzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · BMJ · doi:10.1136/bmj.b2700 · Cited by 17,648 · see citing works
Borenstein, M., Hedges, L. V., Higgins, J. P. T., & Rothstein, H. R. (2009) · doi:10.1002/9780470743386 · Cited by 14,225 · see citing works
Evidence for decreasing quality of semen during past 50 years.
Carlsen, E., Giwercman, A., Keiding, N., & Skakkebæk, N. E. (1992) · BMJ · doi:10.1136/bmj.305.6854.609 · Cited by 2,768 · see citing works
Temporal trends in sperm count: a systematic review and meta-regression analysis
Levine, H., Jørgensen, N., Martino-Andrade, A., Mendiola, J., Weksler-Derri, D., Mindlis, I., Pinotti, R., & Swan, S. H. (2017) · Human Reproduction Update · doi:10.1093/humupd/dmx022 · Cited by 1,374 · see citing works
Self-citationSperm Morphology, Motility, and Concentration in Fertile and Infertile Men
Guzick, D. S., Overstreet, J. W., Factor-Litvak, P., Brazil, C. K., Nakajima, S. T., Coutifaris, C., Carson, S. A., Cisneros, P., Steinkampf, M. P., Hill, J. A., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa003005 · Cited by 1,336 · see citing works
Decline in Semen Quality among Fertile Men in Paris during the Past 20 Years
Auger, J., Kunstmann, J. M., Czyglik, F., & Jouannet, P. (1995) · New England Journal of Medicine · doi:10.1056/nejm199502023320501 · Cited by 1,131 · see citing works
Skakkebæk, N. E., Meyts, E. R., Louis, G. M. B., Toppari, J., Andersson, A., Eisenberg, M. L., Jensen, T. K., Jørgensen, N., Swan, S. H., Sapra, K. J., et al. (2015) · Physiological Reviews · doi:10.1152/physrev.00017.2015 · Cited by 998 · see citing works
Self-citationBonde, J. P. E., Ernst, E., Jensen, T. K., Hjollund, N. H. I., Kolstad, H., Scheike, T., Giwercman, A., Skakkebæk, N. E., Henriksen, T. B., & Olsen, J. (1998) · The Lancet · doi:10.1016/s0140-6736(97)10514-1 · Cited by 791 · see citing works
The question of declining sperm density revisited: an analysis of 101 studies published 1934-1996.
Swan, S. H., Elkin, E. P., & Fenster, L. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108961 · Cited by 708 · see citing works
Self-citationRegional differences in semen quality in Europe
Jørgensen, N., Andersen, A., Eustache, F., Irvine, D. S., Suominen, J. J. O., Petersen, J. H., Andersen, A. N., Auger, J., Cawood, E., Horte, A., et al. (2001) · Human Reproduction · doi:10.1093/humrep/16.5.1012 · Cited by 460 · see citing works
Self-citationIrvine, S., Cawood, E., Richardson, D., MacDonald, E., & Aitken, R. J. (1996) · BMJ · doi:10.1136/bmj.312.7029.467 · Cited by 442 · see citing works
Semen analyses in 1,283 men from the United States over a 25-year period: no decline in quality
Fisch, H., Goluboff, E. T., Olson, J. H., Feldshuh, J., Broder, S. J., & Barad, D. H. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58278-8 · Cited by 413 · see citing works
Environmental factors in declining human fertility
Skakkebæk, N. E., Lindahl-Jacobsen, R., Levine, H., Andersson, A.-M., Jørgensen, N., Main, K. M., Lidegaard, Ø., Priskorn, L., Holmboe, S. A., Bräuner, E. V., et al. (2022) · Nature Reviews Endocrinology · doi:10.1038/s41574-021-00598-8 · Cited by 389 · see citing works
Self-citationEffect of chronic alcoholism on male fertility hormones and semen quality
Muthusami, K. R., & Chinnaswamy, P. (2005) · Fertility and Sterility · doi:10.1016/j.fertnstert.2005.04.025 · Cited by 371 · see citing works
Jørgensen, N. (2002) · Human Reproduction · doi:10.1093/humrep/17.8.2199 · Cited by 318 · see citing works
Self-citationReproductive Functions in Young Fathers and Grandfathers
Nieschlag, E., LAMMERS, U., Freischem, C. W., Langer, K., & Wickings, E. J. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-4-676 · Cited by 312 · see citing works
Jørgensen, N., Joensen, U. N., Jensen, T. K., Jensen, M. B., Almstrup, K., Olesen, I. A., Juul, A., Andersson, A., Carlsen, E., Petersen, J. H., et al. (2012) · BMJ Open · doi:10.1136/bmjopen-2012-000990 · Cited by 291 · see citing works
Self-citationThe Epidemiology of Male Infertility
Winters, B. R., & Walsh, T. J. (2013) · Urologic Clinics of North America · doi:10.1016/j.ucl.2013.08.006 · Cited by 278 · see citing works
Semen Quality and Reproductive Health of Young Czech Men Exposed to Seasonal Air Pollution
Selevan, S. G., Borkovec, L., Slott, V. L., Zudova, Z., Rubeš, J., Evenson, D. P., & Perreault, S. D. (2000) · Environmental Health Perspectives · doi:10.1289/ehp.00108887 · Cited by 265 · see citing works
Gallegos, G., Ramos, B., Santiso, R., Goyanes, V. J., Gosálvez, J., & Fernández, J. L. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.06.035 · Cited by 252 · see citing works
Aneck‐Hahn, N. H., Schulenburg, G. W., Bornman, M. S., Farias, P., & de Jager, C. (2007) · Journal of Andrology · doi:10.2164/jandrol.106.001701 · Cited by 249 · see citing works
Jensen, T. K. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.82.12.4059 · Cited by 225 · see citing works
Deterioration of sperm quality in young healthy Belgian men
Waeleghem, K. V., Clercq, N. D., Vermeulen, L., Schoonjans, F., & Comhaire, F. H. (1996) · Human Reproduction · doi:10.1093/humrep/11.2.325 · Cited by 223 · see citing works
Cigarette smoking and semen quality
Vine, M. F., Tse, C., Hu, P.-C., & Truong, K. Y. (1996) · Fertility and Sterility · doi:10.1016/s0015-0282(16)58223-5 · Cited by 190 · see citing works
High and unchanged sperm counts of Finnish men
Vierula, M. E., Niemi, M., Keiski, A., Saaranen, M., Saarikoski, S., & SUOMINEN, J. (1996) · International Journal of Andrology · doi:10.1111/j.1365-2605.1996.tb00427.x · Cited by 186 · see citing works
Hauser, R. B., Skakkebæk, N. E., Hass, U., Toppari, J., Juul, A., Andersson, A., Kortenkamp, A., Heindel, J. J., & Trasande, L. (2015) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2014-4325 · Cited by 180 · see citing works
The correlates of fertilizing capacity in normal fertile men
Aitken, R. J., Best, F. S. M., Richardson, D. C., Djahanbakhch, O., & Lees, M. M. (1982) · Fertility and Sterility · doi:10.1016/s0015-0282(16)46398-3 · Cited by 167 · see citing works
Recent adverse trends in semen quality and testis cancer incidence among Finnish men
Jørgensen, N., Vierula, M. E., Lindahl‐Jacobsen, R., Pukkala, ., Perheentupa, A. H., Virtanen, H. E., Skakkebæk, N. E., & Toppari, J. (2011) · International Journal of Andrology · doi:10.1111/j.1365-2605.2010.01133.x · Cited by 160 · see citing works
Self-citationLatif, T., Jensen, T. K., Mehlsen, J., Holmboe, S. A., Brinth, L. S., Pors, K., Skouby, S. O., Jørgensen, N., & Lindahl‐Jacobsen, R. (2017) · American Journal of Epidemiology · doi:10.1093/aje/kwx067 · Cited by 158 · see citing works
Self-citationLong-term outcomes of elective human sperm cryostorage
Kelleher, S., Wishart, S. M., Liu, P. Y., Turner, L., Pierro, I. D., Conway, A. J., & Handelsman, D. J. (2001) · Human Reproduction · doi:10.1093/humrep/16.12.2632 · Cited by 145 · see citing works
GYLLENBORG, SKAKKEBÆK, NIELSEN, KEIDING, & GIWERCMAN (1999) · International Journal of Andrology · doi:10.1046/j.1365-2605.1999.00137.x · Cited by 141 · see citing works
Jonge, C. J. D., & Barratt, C. L. R. (2019) · Andrology · doi:10.1111/andr.12673 · Cited by 139 · see citing works
Semen quality of Indian welders occupationally exposed to nickel and chromium
Danadevi, K., Rozati, R., Reddy, P. P., & Grover, P. (2003) · Reproductive Toxicology · doi:10.1016/s0890-6238(03)00040-6 · Cited by 138 · see citing works
Polybrominated Diphenyl Ethers in Human Serum and Sperm Quality
Akutsu, K., Takatori, S., Nozawa, S., Yoshiike, M., Nakazawa, H., Hayakawa, K., Makino, T., & Iwamoto, T. (2008) · Bulletin of Environmental Contamination and Toxicology · doi:10.1007/s00128-008-9370-4 · Cited by 137 · see citing works
Separation efficiency of a microfluidic sperm sorter to minimize sperm DNA damage
Shirota, K., Yotsumoto, F., Itoh, H., Obama, H., Hidaka, N., Nakajima, K., & Miyamoto, S. (2015) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.10.023 · Cited by 137 · see citing works
Sperm Shape Abnormalities in Carbaryl-Exposed Employees
Wyrobek, A. J., Watchmaker, G., Gordon, L. A., Wong, K., Moore, D., & Whorton, D. (1981) · Environmental Health Perspectives · doi:10.1289/ehp.8140255 · Cited by 134 · see citing works
Stewart, T. M., Liu, D. Y., Garrett, C., Jørgensen, N., Brown, E., & Baker, H. W. G. (2009) · Human Reproduction · doi:10.1093/humrep/dep075 · Cited by 129 · see citing works
Self-citationThe changing tide of human fertility
Aitken, R. J. (2022) · Human Reproduction · doi:10.1093/humrep/deac011 · Cited by 129 · see citing works
Bujan, L., Walschaerts, M., Moinard, N., Hennebicq, S., Saias‐Magnan, J., Brugnon, F., Auger, J., Berthaut, I., Szerman, E., Daudin, M., et al. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.05.018 · Cited by 128 · see citing works
Detection of high-risk HPV DNA in semen and its association with the quality of semen
Rintala, M. A. M., Grénman, S., Pöllänen, P., Suominen, J. J. O., & Syrjänen, S. (2004) · International Journal of STD & AIDS · doi:10.1258/0956462042395122 · Cited by 126 · see citing works
Brahem, S., Mehdi, M., Elghezal, H., & Saâd, A. (2011) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-011-9537-5 · Cited by 126 · see citing works
Effects of prolonged autovehicle driving on male reproductive function: A study among taxi drivers
Fig�-Talamanca, I., Cini, C., Varricchio, G. C., Dondero, F., Gandini, L., Lenzi, A., Lombardo, F. P., Angelucci, L., Grezia, R. D., & Patacchioli, F. R. (1996) · American Journal of Industrial Medicine · doi:10.1002/(sici)1097-0274(199612)30:6 · Cited by 122 · see citing works
Oxidative stress induced sperm DNA damage, a possible reason for male infertility.
Hosen, M. B., Islam, M. R., Begum, F., Kabir, Y., & Howlader, M. Z. H. (2015) · Europe PMC (PubMed Central) · Cited by 119 · see citing works
Subclinical alterations in hormone and semen profile in athletes
Arce, J.-C., Souza, M. J. D., Pescatello, L. S., & Luciano, A. A. (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55684-2 · Cited by 118 · see citing works
Auger, J., & Jouannet, P. (1997) · Human Reproduction · doi:10.1093/humrep/12.4.740 · Cited by 118 · see citing works
Sperm aneuploidy rates in younger and older men
Luetjens, C. M., Rolf, C., Gassner, P., Werny, J. E., & Nieschlag, E. (2002) · Human Reproduction · doi:10.1093/humrep/17.7.1826 · Cited by 116 · see citing works
Semen Parameters in Men with and Without Proven Chronic Prostatitis
Weidner, W., Jantos, C. A., Schiefer, H. G., Haidl, G., & Friedrich, H. J. (1991) · Archives of Andrology · doi:10.3109/01485019108987640 · Cited by 111 · see citing works
Toft, G. V., Axmon, A., Giwercman, A., Thulstrup, A. M., Rignell‐Hydbom, A., Pedersen, H. S., Ludwicki, J. K., Zvyezday, V., Zinchuk, A., Spanò, M., et al. (2005) · Environmental Health · doi:10.1186/1476-069x-4-26 · Cited by 110 · see citing works
Wu, B., Lu, N., Xia, Y., Gu, A., Lu, C., Wang, W., Song, L., Wang, S. L., Shen, H., & Wang, X. R. (2007) · Human Reproduction · doi:10.1093/humrep/del499 · Cited by 109 · see citing works
Sperm Count and Hypogonadism as Markers of General Male Health
Ferlin, A., Garolla, A., Ghezzi, M., Selice, R., Palego, P., Caretta, N., Mambro, A. D., Valente, U., Ponce, M. D. R., Dipresa, S., et al. (2019) · European Urology Focus · doi:10.1016/j.euf.2019.08.001 · Cited by 108 · see citing works
What constitutes a normal seminal analysis? Semen parameters of 243 fertile men
Chia, S. E., Tay, S. K., & Lim, S. (1998) · Human Reproduction · doi:10.1093/humrep/13.12.3394 · Cited by 108 · see citing works
Clinical Significance of Sperm DNA Damage Threshold Value in the Assessment of Male Infertility
Venkatesh, S., Singh, A., Shamsi, M. B., Thilagavathi, J., Kumar, R., Mitra, D., & Dada, R. (2011) · Reproductive Sciences · doi:10.1177/1933719111401662 · Cited by 108 · see citing works
Oxidative stress and sperm mitochondrial DNA mutation in idiopathic oligoasthenozoospermic men.
Kumar, R., Venkatesh, S., Kumar, M., Tanwar, M., Shasmsi, M. B., Kumar, R., Gupta, N. P., Sharma, R. K., Talwar, P., & Dada, R. (2009) · PubMed · Cited by 102 · see citing works
Spermatogenic ability is different among males in different Y chromosome lineage
Kuroki, Y., Iwamoto, T., Lee, J., Yoshiike, M., Nozawa, S., Nishida, T., Ewis, A. A., Nakamura, H., Toda, T., Tokunaga, K., et al. (1999) · Journal of Human Genetics · doi:10.1007/s100380050162 · Cited by 102 · see citing works
Analysis of sperm telomere length in men with idiopathic infertility
Thilagavathi, J., Kumar, M., Mishra, S. S., Venkatesh, S., Kumar, R., & Dada, R. (2013) · Archives of Gynecology and Obstetrics · doi:10.1007/s00404-012-2632-8 · Cited by 101 · see citing works
Sperm output of healthy men in Australia: magnitude of bias due to self- selected volunteers
Handelsman, D. J. (1997) · Human Reproduction · doi:10.1093/humrep/12.12.2701 · Cited by 101 · see citing works
Changing parameters of donor semen
Leto, S., & Frensilli, F. J. (1981) · Fertility and Sterility · doi:10.1016/s0015-0282(16)45923-6 · Cited by 100 · see citing works
Recio‐Vega, R., Ocampo‐Gómez, G., Borja‐Aburto, V. H., Morán‐Martínez, J., & Cebrián‐García, M. E. (2007) · Journal of Applied Toxicology · doi:10.1002/jat.1321 · Cited by 99 · see citing works
Semen quality of workers occupationally exposed to hydrocarbons
Célis, R. D., Feria‐Velasco, A., González‐Unzaga, M., Torres-Calleja, J., & Pedrón-Nuevo, N. (2000) · Fertility and Sterility · doi:10.1016/s0015-0282(99)00515-4 · Cited by 99 · see citing works
Effects of stress and characteristic adaptability on semen quality in healthy men
Giblin, P. T., Poland, M. L., Moghissi, K. S., Ager, J. W., & Olson, J. M. (1988) · Fertility and Sterility · doi:10.1016/s0015-0282(16)59663-0 · Cited by 98 · see citing works
Estimating fertility potential via semen analysis data
BARTOOV, B., Eltes, F., Pansky, M., Lederman, H., Caspi, E., & Soffer, Y. (1993) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a137876 · Cited by 98 · see citing works
Ayers, J. W. T., Komesu, Y., Romani, T., & Ansbacher, R. (1985) · Fertility and Sterility · doi:10.1016/s0015-0282(16)48622-x · Cited by 98 · cited 1× · see citing works
“Data from the 223 publications included in the meta-analysis are available upon reasonable request through contact with corresponding author (Abyholm, 1981; Fariss et al., 1981; Leto and Frensilli, 1981; Wyrobek et al., 1981a,b; Aitken et al., 1982; Nieschlag et al., 1982; Obwaka et al., 1982; Albertsen et al., 1983;…”
Prediction of spontaneous conception based on semen parameters
Jędrzejczak, P., Taszarek-Hauke, G., Hauke, J., Pawelczyk, L. A., & Dulęba, A. J. (2007) · International Journal of Andrology · doi:10.1111/j.1365-2605.2007.00799.x · Cited by 97 · see citing works
No secular trend over the last decade in sperm counts among Swedish men from the general population
Axelsson, J., Rylander, L., Rignell‐Hydbom, A., & Giwercman, A. (2011) · Human Reproduction · doi:10.1093/humrep/der045 · Cited by 97 · see citing works
Evolution of the WHO “Semen” processing manual from the first (1980) to the sixth edition (2021)
Wang, C., Mbizvo, M. T., Festin, M., Björndahl, L., & Toskin, I. (2022) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.11.037 · Cited by 97 · see citing works
Paasch, U., Salzbrunn, A., Glander, H., Plambeck, K., Salzbrunn, H., Grunewald, S., Stucke, J., Skakkebæk, N. E., & Jørgensen, N. (2008) · International Journal of Andrology · doi:10.1111/j.1365-2605.2007.00860.x · Cited by 95 · see citing works
Self-citationSemen quality in relation to antioxidant intake in a healthy male population
Zareba, P., Colaci, D., Afeiche, M. C., Gaskins, A. J., Jørgensen, N., Mendiola, J., Swan, S. H., & Chavarro, J. E. (2013) · Fertility and Sterility · doi:10.1016/j.fertnstert.2013.08.032 · Cited by 94 · see citing works
Self-citationSperm counts may have declined in young university students in Southern Spain
Mendiola, J., Jørgensen, N., Mínguez‐Alarcón, L., Sarabia‐Cos, L., López-Espín, J. J., Vivero‐Salmerón, G., Ruiz‐Ruiz, K. J., Fernández, M. F., Olea, N., Swan, S. H., et al. (2013) · Andrology · doi:10.1111/j.2047-2927.2012.00058.x · Cited by 93 · see citing works
Self-citationHigher sperm counts in Southern Sweden compared with Denmark
Richthoff, J. (2002) · Human Reproduction · doi:10.1093/humrep/17.9.2468 · Cited by 93 · see citing works
Semen Analysis in Insulin-Dependent/Non-Insulin-Dependent Diabetic Men with/without Neuropathy
Ali, S. T., Shaikh, R. N., Siddiqi, N. A., & Siddiqi, P. Q. R. (1993) · Archives of Andrology · doi:10.3109/01485019308988368 · Cited by 92 · see citing works
Kobayashi, K., Masumori, N., Hisasue, S., Kato, R., Hashimoto, K., Itoh, N., & Tsukamoto, T. (2008) · The Journal of Sexual Medicine · doi:10.1111/j.1743-6109.2008.00779.x · Cited by 90 · see citing works
Plastira, K., Msaouel, P., Angelopoulou, R., Kyriaki, Z., Plastiras, A., Πόθος, Α., Bolaris, S., Paparisteidis, N., & Mantas, D. (2007) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-007-9162-5 · Cited by 88 · see citing works
Mínguez‐Alarcón, L., Sergeyev, O., Burns, J. S., Williams, P. L., Lee, M., Korrick, S., Smigulina, L., Revich, B., & Hauser, R. B. (2016) · Environmental Health Perspectives · doi:10.1289/ehp25 · Cited by 88 · see citing works
Effects of Pesticide Use on Semen Quality among Farmers in Rural Areas of Sabah, Malaysia
Hossain, F., Ali, O., D'Souza, U. J. A., & Naing, D. K. S. (2010) · Journal of Occupational Health · doi:10.1539/joh.l10006 · Cited by 87 · see citing works
Cadmium, lead, selenium, and zinc in semen of occupationally unexposed men
Noack-Füller, G., Beer, C., & Seibert, H. (2009) · Andrologia · doi:10.1111/j.1439-0272.1993.tb02674.x · Cited by 84 · see citing works
Effect of smoking on semen quality of infertile men in Shandong, China.
Zhang, J., Meng, Q. Y., Wang, L., Zhang, L. J., Mao, Y. L., & Sun, Z. (2000) · PubMed · Cited by 82 · see citing works
Task Force on Methods for the Regulation of Male Fertility (1993) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56411-5 · Cited by 82 · see citing works
Exploration of the Association between Obesity and Semen Quality in a 7630 Male Population
Tsao, C., Liu, C.-Y., Chou, Y., Cha, T., Chen, S.-C., & Hsu, C. (2015) · PLoS ONE · doi:10.1371/journal.pone.0119458 · Cited by 80 · see citing works
Regional differences in semen qualities in the Baltic region
Punab, M., Žilaitienė, B., Jørgensen, N., Horte, A., Matulevičius, V., Peetsalu, A., & Skakkebæk, N. E. (2002) · International Journal of Andrology · doi:10.1046/j.1365-2605.2002.00359.x · Cited by 80 · see citing works
Self-citationEtiology and Risk Factors Associated With Infertility
Moridi, A., Roozbeh, N., Yaghoobi, H., Soltani, S., Dashti, S., Shahrahmani, N., & Banaei, M. (2019) · International Journal of Women s Health and Reproduction Sciences · doi:10.15296/ijwhr.2019.57 · Cited by 80 · see citing works
Alterations of seminal and hormonal parameters: An extrahepatic manifestation of HCV infection
Durazzo, M. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i19.3073 · Cited by 79 · see citing works
Røste, L. S., Taubøll, E., Haugen, T. B., Bjørnenak, T., Sætre, E., & Gjerstad, L. (2003) · European Journal of Neurology · doi:10.1046/j.1468-1331.2003.00615.x · Cited by 78 · see citing works
Rubes, J., Rybář, R., Přinosilová, P., Veznik, Z., Chvátalová, I., Solánský, I., & Sram, R. (2010) · Mutation research · doi:10.1016/j.mrfmmm.2009.09.010 · Cited by 78 · see citing works
Semen quality of 324 fertile Japanese men
Iwamoto, T., Nozawa, S., Yoshiike, M., Hoshino, T., Baba, K., Matsushita, T., Tanaka, N., Naka, M., Skakkebæk, N. E., & Jørgensen, N. (2005) · Human Reproduction · doi:10.1093/humrep/dei362 · Cited by 77 · see citing works
Self-citationSemen Quality and Reproductive Sex Hormone Levels in Peruvian Pesticide Sprayers
Yucra, S., Rubio, J., Gasco, M., Gonzales, C., Steenland, K., & Gonzales, G. F. (2006) · International Journal of Occupational and Environmental Health · doi:10.1179/oeh.2006.12.4.355 · Cited by 77 · see citing works
Kukuvitis, A., Georgiou, I. A., Bouba, I., Tsirka, A., Giannouli, C., Yapijakis, C., Tarlatzis, B. C., Bontis, J. N., Lolis, D., Sofikitis, N., et al. (2002) · International Journal of Andrology · doi:10.1046/j.1365-2605.2002.00339.x · Cited by 77 · see citing works
MULLER, C. H., Coombs, R. W., & Krieger, J. N. (2009) · Andrologia · doi:10.1111/j.1439-0272.1998.tb02821.x · Cited by 75 · see citing works
Comhaire, F. H., Vermeulen, L., & Schoonjans, F. (1987) · International Journal of Andrology · doi:10.1111/j.1365-2605.1987.tb00366.x · Cited by 75 · see citing works
Relationship between sperm characteristics and hormonal parameters in normal couples
Uhler, M. L., Zinaman, M. J., Brown, C., & Clegg, E. D. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00336-4 · Cited by 74 · see citing works
Andrology: Clinical and biological characteristics of infertile men with a history of cryptorchidism
Mieusset, R., Bujan, L., Massat, G., MANSAT, A., & Pontonnier, F. (1995) · Human Reproduction · doi:10.1093/oxfordjournals.humrep.a135998 · Cited by 74 · see citing works
Priskorn, L., Nordkap, L., Bang, A. K., Krause, M., Holmboe, S. A., Egeberg Palme, D. L., Winge, S. B., Mørup, N., Carlsen, E., Joensen, U. N., et al. (2018) · Human Reproduction · doi:10.1093/humrep/dey090 · Cited by 73 · see citing works
Self-citationTaneja, N., Kucheria, K., Jain, S., & Maheshwari, M. C. (1994) · Epilepsia · doi:10.1111/j.1528-1157.1994.tb02923.x · Cited by 72 · see citing works
Semen Parameters in Norwegian Fertile Men
Haugen, T. B., Egeland, T., & Magnus, Ø. (2006) · Journal of Andrology · doi:10.2164/jandrol.05010 · Cited by 72 · see citing works
Liu, J., Wang, Q., Ji, X., Guo, S., Dai, Y., Zhang, Z., Liting, J., Shi, Y., Tai, S., & Lee, Y. (2014) · Urology · doi:10.1016/j.urology.2013.11.009 · Cited by 72 · see citing works
Girela, J. L., Gil, D., Johnsson, M., Gómez‐Torres, M. J., & Juan, J. D. (2013) · Biology of Reproduction · doi:10.1095/biolreprod.112.104653 · Cited by 70 · see citing works
Auger, J., & Eustache, F. (2010) · International Journal of Andrology · doi:10.1111/j.1365-2605.2010.01124.x · Cited by 69 · see citing works
Water- and Fat-Soluble Antioxidants in Human Seminal Plasma and Serum of Fertile Males
Lazzarino, G., Listorti, I., Bilotta, G., Capozzolo, T., Amorini, A. M., Longo, S. A., Caruso, G., Caruso, G., Tavazzi, B., & Bilotta, P. (2019) · Antioxidants · doi:10.3390/antiox8040096 · Cited by 69 · see citing works
Xiao, G., Cui Bao, P. A. N., Yao Zhang, C. A. I., Lin, H., & Zhan Ming, F. U. (2001) · Industrial Health · doi:10.2486/indhealth.39.206 · Cited by 69 · see citing works
Bang, A. K., Carlsen, E., Holm, M., Petersen, J. H., Skakkebæk, N. E., & Jørgensen, N. (2005) · Human Reproduction · doi:10.1093/humrep/dei170 · Cited by 68 · see citing works
Self-citationAir-conditioned environments do not prevent deterioration of human semen quality during the summer
Levine, R. J., Brown, M. H., Bell, M., Shue, F., Greenberg, G. N., & Bordson, B. L. (1992) · Fertility and Sterility · doi:10.1016/s0015-0282(16)55027-4 · Cited by 68 · see citing works
Smoking is associated with the retention of cytoplasm by human spermatozoa
Mak, V., Jarvi, K., Buckspan, M., Freeman, M., Hechter, S., & Zini, A. (2000) · Urology · doi:10.1016/s0090-4295(00)00700-7 · Cited by 67 · see citing works
Recabarren, S. E., Sir‐Petermann, T., Ríos, R., Maliqueo, M. A., Echiburú, B., Smith, R., Rojas-Garcia, P. P., Recabarren, M. P., & Rey, R. A. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-0255 · Cited by 65 · see citing works
Semen quality and sex hormones among organic and traditional Danish farmers. ASCLEPIOS Study Group.
Larsen, S. B., Spano, M., Giwercman, A., & Bonde, J. P. (1999) · Occupational and Environmental Medicine · doi:10.1136/oem.56.2.139 · Cited by 65 · see citing works
Epidemiological Study of the Effects of Carbon Disulfide on Male Sexuality and Reproduction
Vanhoorne, M., Comhaire, F. H., & Bacquer, D. D. (1994) · Archives of Environmental Health An International Journal · doi:10.1080/00039896.1994.9937479 · Cited by 65 · see citing works
Semen parameters in fertile US men: the Study for Future Families
Redmon, J. B., Thomas, W., Ma, W., Drobnis, E. Z., Sparks, A. E., Wang, C., Brazil, C. K., Overstreet, J. W., Liu, F., & Swan, S. H. (2013) · Andrology · doi:10.1111/j.2047-2927.2013.00125.x · Cited by 64 · see citing works
Self-citationThe role of hypothyroidism in male infertility and erectile dysfunction.
Nikoobakht, M. R., Aloosh, M., Nikoobakht, N., Mehrsay, A., Biniaz, F., & Karjalian, M. A. (2012) · Urology journal./Urology jornal. · Cited by 64 · see citing works
Castiglione, R., Salemi, M., Vicari, L. O., & Vicari, E. S. D. (2013) · Andrologia · doi:10.1111/and.12207 · Cited by 63 · see citing works
Vončina, S. M., Golob, B., Ihan, A., Kopitar, A., Kolbezen, M., & Zorn, B. (2016) · Fertility and Sterility · doi:10.1016/j.fertnstert.2015.11.037 · Cited by 61 · see citing works
Karimian, M., & Colagar, A. H. (2014) · Reproduction Fertility and Development · doi:10.1071/rd14186 · Cited by 60 · see citing works
Sperm morphology and recurrent abortion
Hill, J. A., Abbott, A. F., & Politch, J. A. (1994) · Fertility and Sterility · doi:10.1016/s0015-0282(16)56661-8 · Cited by 59 · see citing works
Testicular volume, semen profile and serum hormone levels in fertile Thai males
Aribarg, A., Kenkeerati, W., Vorapaiboonsak, V., Leepipatpaiboon, S., & Farley, T. M. M. (1986) · International Journal of Andrology · doi:10.1111/j.1365-2605.1986.tb00880.x · Cited by 58 · see citing works
Change in semen quality and sperm chromatin structure following occupational styrene exposure
Kolstad, H. A., Bonde, J. P., Spano, M., Giwercman, A., Zschiesche, W., Kaae, D., Larsen, S. B., & Roeleveld, N. (1999) · International Archives of Occupational and Environmental Health · doi:10.1007/s004200050352 · Cited by 58 · see citing works
Firman, R. C. (2003) · Human Reproduction · doi:10.1093/humrep/deg174 · Cited by 58 · see citing works
Hammadeh, M. E., GREINER, S., Rosenbaum, P., & Schmidt, W. K. (2001) · Journal of Andrology · doi:10.1002/j.1939-4640.2001.tb03442.x · Cited by 57 · see citing works
Tsarev, I., Bungum, M., Giwercman, A., Erenpreisa, J., Ebessen, T., Ernst, E., & Ērenpreiss, J. (2009) · Human Reproduction · doi:10.1093/humrep/dep068 · Cited by 56 · see citing works
Heterologous Ovum Penetration Test and Seminal Parameters in Fertile and Infertile Men
Wickings, E. J., Freischem, C. W., Langer, K., & Nieschlag, E. (1983) · Journal of Andrology · doi:10.1002/j.1939-4640.1983.tb02364.x · Cited by 55 · see citing works
Huang, L.-P., Lee, C.-C., Fan, J.-P., Kuo, P., Shih, T., & Hsu, P. (2013) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-013-0905-6 · Cited by 54 · see citing works
Frequently subnormal semen profiles of normal volunteers recruited over 17 years
Lemcke, B., Behre, H. M., & Nieschlag, E. (1997) · International Journal of Andrology · doi:10.1046/j.1365-2605.1997.00045.x · Cited by 54 · see citing works
Splingart, C., Frapsauce, C., Veau, S., Barthélémy, C., Royère, D., & Guérif, F. (2011) · International Journal of Andrology · doi:10.1111/j.1365-2605.2011.01229.x · Cited by 53 · see citing works
Fetic, S., Yeung, C., Sonntag, B., Nieschlag, E., & Cooper, T. G. (2006) · Journal of Andrology · doi:10.2164/jandrol.05122 · Cited by 53 · see citing works
Sperm Studies in Anesthesiologists
Wyrobek, A. J., Brodsky, J. B., Gordon, L. A., Moore, D. H., Watchmaker, G., & Cohen, E. N. (1981) · Anesthesiology · doi:10.1097/00000542-198111000-00008 · Cited by 53 · see citing works
Semen quality of 1559 young men from four cities in Japan: a cross-sectional population-based study
Iwamoto, T., Nozawa, S., Mieno, M., Yamakawa, K., Baba, K., Yoshiike, M., Namiki, M., Koh, E., Kanaya, J., Okuyama, Ä., et al. (2013) · BMJ Open · doi:10.1136/bmjopen-2012-002222 · Cited by 50 · see citing works
Self-citationIncreased Mortality Among Men Diagnosed With Impaired Fertility: Analysis of US Claims Data
Giudice, F. D., Kasman, A. M., Li, S., Belladelli, F., Ferro, M., COBELLI, O. D., BERARDINIS, E. D., Busetto, G. M., & Eisenberg, M. L. (2020) · Urology · doi:10.1016/j.urology.2020.07.087 · Cited by 49 · see citing works
Reversible azoospermia induced by an androgen‐progestin combination regimen in Indonesian men
Pangkahila, W. I. (1991) · International Journal of Andrology · doi:10.1111/j.1365-2605.1991.tb01089.x · Cited by 49 · see citing works
Le Moal, J., Sharpe, R. M., Jϕrgensen, N., Levine, H., Jurewicz, J., Mendiola, J., Swan, S. H., Virtanen, H., Christin-Maître, S., Cordier, S., et al. (2016) · The European Journal of Public Health · doi:10.1093/eurpub/ckv153 · Cited by 48 · see citing works
Self-citationXu, D., Zhu, Q., Lu-kang, Z., Wang, Q., Shen, H., Deng, L.-X., & Ong, C. N. (2003) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/s1383-5718(03)00055-x · Cited by 48 · see citing works
Role of glutathione S-transferase Mu-1 (GSTM1) polymorphism in oligospermic infertile males
Vani, G. T., Mukesh, N., Prasad, B. S., Devi, P. R., Prasad, M. H., Rani, P. U., & Reddy, P. P. (2010) · Andrologia · doi:10.1111/j.1439-0272.2009.00971.x · Cited by 47 · see citing works
Multigner, L., Ben-Brik, E., Arnaud, I., Haguenoer, J. M., Jouannet, P., Auger, J., & Eustache, F. (2007) · Occupational and Environmental Medicine · doi:10.1136/oem.2005.023952 · Cited by 47 · see citing works
Incomplete protection of genetic integrity of mature spermatozoa against oxidative stress
Linschooten, J. O., Laubenthal, J., Cemeli, E., Baumgartner, A., Anderson, D. C., Sipinen, V. E., Brunborg, G., Haenen, G. R. M. M., Fthenou, E., Briedé, J. J., et al. (2011) · Reproductive Toxicology · doi:10.1016/j.reprotox.2011.05.004 · Cited by 46 · see citing works
O'Donovan, M. (2005) · Andrologia · doi:10.1111/j.1439-0272.2005.00658.x · Cited by 46 · see citing works
Paraoxonase-1 activity in subfertile men and relationship to sperm parameters.
Verit, F., Verit, A., Çiftçi, H., Erel, O., & Çelik, H. (2008) · Journal of Andrology · doi:10.2164/jandrol.108.004929 · Cited by 46 · see citing works
Insurance coverage for male infertility care in the United States
Dupree, J. M. (2016) · Asian Journal of Andrology · doi:10.4103/1008-682x.177838 · Cited by 46 · see citing works
Mohammed, E. M., Mosad, E., Zahran, A. M., Hameed, D. A., Taha, E. A., & Mohamed, M. A. (2015) · Advances in Urology · doi:10.1155/2015/814150 · Cited by 45 · see citing works
Fariss, B. L., Fenner, D. K., Plymate, S. R., Brannen, G. E., Jacob, W. H., & Thomason, A. M. (1981) · Fertility and Sterility · doi:10.1016/s0015-0282(16)45380-x · Cited by 45 · see citing works
Does attractiveness in men provide clues to semen quality?
PETERS, M., Rhodes, G., & Simmons, L. W. (2008) · Journal of Evolutionary Biology · doi:10.1111/j.1420-9101.2007.01477.x · Cited by 44 · see citing works
Rignell-Hydbom, A., Axmon, A., Lundh, T., Jönsson, B., Tiido, T., & Spanô, M. (2007) · Environmental Health · doi:10.1186/1476-069x-6-14 · Cited by 44 · see citing works
Setting Standards of Male Fertility I. Semen Analyses in 1500 Patients - A Report
Sheriff, D. S. (2009) · Andrologia · doi:10.1111/j.1439-0272.1983.tb00194.x · Cited by 43 · see citing works
The future of sperm: a biovariability framework for understanding global sperm count trends
Boulicault, M., Perret, M., Galka, J. M., Borsa, A., Gompers, A. D., Reiches, M. W., & Richardson, S. S. (2021) · Human Fertility · doi:10.1080/14647273.2021.1917778 · Cited by 43 · see citing works
Fedder, J., Askjaer, S. A., & Hjort, T. (1993) · Archives of Andrology · doi:10.3109/01485019308988386 · Cited by 43 · see citing works
Evgeni, E., Lymberopoulos, G., Gazouli, M., & Asimakopoulos, B. (2015) · European Journal of Obstetrics & Gynecology and Reproductive Biology · doi:10.1016/j.ejogrb.2015.02.026 · Cited by 42 · see citing works
Semen quality of fertile Japanese men: a cross-sectional population-based study of 792 men
Iwamoto, T., Nozawa, S., Yoshiike, M., Namiki, M., Koh, E., Kanaya, J., Okuyama, Ä., Matsumiya, K., Tsujimura, A., Komatsu, K., et al. (2013) · BMJ Open · doi:10.1136/bmjopen-2012-002223 · Cited by 42 · see citing works
Self-citationIs abnormal sperm function an indicator among couples with recurrent pregnancy loss?
Saxena, P., Misro, M. M., Chaki, S. P., Chopra, K., Roy, S., & Nandan, D. (2008) · Fertility and Sterility · doi:10.1016/j.fertnstert.2007.09.031 · Cited by 41 · see citing works
Genetic monitoring of aluminum workers exposed to coal tar pitch volatiles
Heussner, J. C., Ward, J. B., & Legator, M. S. (1985) · Mutation Research/Genetic Toxicology · doi:10.1016/0165-1218(85)90133-8 · Cited by 41 · see citing works
Bhattacharya, S. M. (2008) · International Urology and Nephrology · doi:10.1007/s11255-007-9282-y · Cited by 39 · see citing works
Declining sperm quality in New Zealand over 20 years.
Shine, R., Peek, J., & Birdsall, M. A. (2008) · PubMed · Cited by 38 · see citing works
Are worldwide sperm counts declining?
Jørgensen, N., Lamb, D. J., Levine, H., Pastuszak, A. W., Sigalos, J. T., Swan, S. H., & Eisenberg, M. L. (2021) · Fertility and Sterility · doi:10.1016/j.fertnstert.2021.10.020 · Cited by 37 · see citing works
Self-citationReproductive parameters in young men living in Rochester, New York
Mendiola, J., Jørgensen, N., Andersson, A., Stahlhut, R. W., Liu, F., & Swan, S. H. (2014) · Fertility and Sterility · doi:10.1016/j.fertnstert.2014.01.007 · Cited by 37 · see citing works
Self-citationThe effect of cryptorchidism on inhibin B in a subfertile population
Brazao, C. A. D. G., Pierik, F. H., Erenpreiss, Y., de Jong, F. H., Dohle, G. R., & Weber, R. F. A. (2003) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2003.01813.x · Cited by 37 · see citing works
Total antioxidant capacity and lipid peroxidation in semen of patient with hyperviscosity.
Layali, I., Tahmasbpour, E., Joulaei, M., Jorsaraei, S. G. A., & Farzanegi, P. (2015) · Europe PMC (PubMed Central) · doi:10.22074/cellj.2015.500 · Cited by 37 · see citing works
Goulis, D. G., Iliadou, P. K., Tsametis, C. P., Gerou, S., Tarlatzis, B. C., Bontis, I. N., & Papadimas, I. (2008) · Gynecological Endocrinology · doi:10.1080/09513590701672314 · Cited by 36 · see citing works
No Decline in Semen Quality Among Potential Sperm Donors in Sydney, Australia, Between 1983 and 2001
Costello, M., Sjöblom, P., Haddad, Y., Steigrad, S. J., & Bosch, E. G. (2002) · Journal of Assisted Reproduction and Genetics · doi:10.1023/a:1015729314081 · Cited by 36 · see citing works
Semen quality and sperm functional parameters in fertile Indian men
Pal, P. C., Rajalakshmi, M., Manocha, M., Sharma, R. S., Mittal, S., & Rao, D. N. (2006) · Andrologia · doi:10.1111/j.1439-0272.2006.00685.x · Cited by 35 · see citing works
Effect of Benzene Exposure on Fertility of Male Workers Employed in Bulk Drug Industries
Katukam, V., Kulakarni, M., Syed, R., Alharbi, K., & Naik, J. (2012) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2011.0241 · Cited by 35 · see citing works
Is inhibin B involved in the toxic effect of lead on male reproduction?
MAHMOUD, A., Kiss, P., Vanhoorne, M., Bacquer, D. D., & Comhaire, F. H. (2005) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00524.x · Cited by 35 · see citing works
Ward, J. B., Hokanson, J. A., Smith, E. R., Chang, L. W., Pereira, M. A., Whorton, E. B., & Legator, M. S. (1984) · Mutation Research/Environmental Mutagenesis and Related Subjects · doi:10.1016/0165-1161(84)90014-1 · Cited by 34 · see citing works
Reference value of semen quality in Chinese young men
Jun-qing, W., Qiuying, Y., Jianguo, T., Wei, Y., Bo, L.-W., Li, Y.-X., Yumei, Z., Kangshou, Y., Lu, W., Chen, L., et al. (2002) · Contraception · doi:10.1016/s0010-7824(02)00281-0 · Cited by 33 · see citing works
Sperm as an indicator of reproductive risk among petroleum refinery workers.
Rosenberg, M. J., Wyrobek, A. J., Ratcliffe, J. M., Gordon, L. A., Watchmaker, G., Fox, S., Moore, D. H., & Hornung, R. (1985) · Occupational and Environmental Medicine · doi:10.1136/oem.42.2.123 · Cited by 32 · see citing works
An update on semen quality among young Finnish men and comparison with Danish data
Rodprasert, W., Virtanen, H. E., Sadov, S., Perheentupa, A. H., Skakkebæk, N. E., Jørgensen, N., & Toppari, J. (2018) · Andrology · doi:10.1111/andr.12550 · Cited by 32 · see citing works
Self-citationDiagnostic value of bioactive FSH in male infertility
Jockenhövel, F., Khan, S. A., & Nieschlag, E. (1989) · European Journal of Endocrinology · doi:10.1530/acta.0.1210802 · Cited by 31 · see citing works
Giagulli, V. A., Carbone, M. D., Pergola, G. D., Guastamacchia, E., Resta, F., Licchelli, B., Sabbà, C., & Triggiani, V. (2014) · Journal of Assisted Reproduction and Genetics · doi:10.1007/s10815-014-0221-4 · Cited by 31 · see citing works
Lotti, F., Corona, G., Cocci, A., Cipriani, S., Baldi, E., Degl’Innocenti, S., Franco, P. N., Gacci, M., & Maggi, M. (2018) · Human Reproduction · doi:10.1093/humrep/dey298 · Cited by 31 · see citing works
Single semen analysis as a predictor of semen quality: clinical and epidemiological implications
Rylander, L., Wetterstrand, B., Haugen, T. B., Malm, G., Malm, J., Bjørsvik, C., Henrichsen, T., Sæther, T., & Giwercman, A. (2009) · Asian Journal of Andrology · doi:10.1038/aja.2009.64 · Cited by 30 · see citing works
Царев, И. Л., GAGONIN, V., Giwercman, A., & Ērenpreiss, J. (2005) · International Journal of Andrology · doi:10.1111/j.1365-2605.2005.00523.x · Cited by 30 · see citing works
Korrovits, P., Ausmees, K., Mändar, R., & Punab, M. (2008) · Urology · doi:10.1016/j.urology.2007.12.082 · Cited by 30 · see citing works
Clinical Relevance of Vitamin C Among Lead-Exposed Infertile Men
Vani, K., Kurakula, M., Syed, R., & Alharbi, K. (2012) · Genetic Testing and Molecular Biomarkers · doi:10.1089/gtmb.2012.0027 · Cited by 30 · see citing works
Association of polymorphisms in genes coding for antioxidant enzymes and human male infertility
Rodríguez, A. G., de la Casa, M., Johnston, S. D., Gosálvez, J., & Roy, R. (2018) · Annals of Human Genetics · doi:10.1111/ahg.12286 · Cited by 30 · see citing works
A Critical Method of Evaluating Tests for Male Infertility
Albertsen, P. C., CHANG, T. S. K., Vindivich, D., Robinson, J. C., & Smyth, J. W. (1983) · The Journal of Urology · doi:10.1016/s0022-5347(17)51253-7 · Cited by 29 · see citing works
Halling, J., Petersen, M. S., Jørgensen, N., Jensen, T. K., Grandjean, P., & Weihe, P. (2013) · BMJ Open · doi:10.1136/bmjopen-2012-001946 · Cited by 28 · see citing works
Self-citationReproductive History and Semen Analysis in Prevasectomy Fertile Men with and without Varicocele
de Castro, M. P. P., & MASTROROCCO, D. A. M. (1984) · Journal of Andrology · doi:10.1002/j.1939-4640.1984.tb00772.x · Cited by 28 · see citing works
Tainio, J., Jahnukainen, K., Nurmio, M., Pakarinen, M. P., Jalanko, H., & Jahnukainen, T. (2014) · Transplantation · doi:10.1097/tp.0000000000000173 · Cited by 28 · see citing works
Antisperm antibodies in infertile men and their correlation with seminal parameters
Garcia, P. C., Rúbio, E. M., & Pereira, O. C. M. (2007) · Reproductive Medicine and Biology · doi:10.1111/j.1447-0578.2007.00162.x · Cited by 28 · see citing works
Association of CYP1A1*2A polymorphism with male infertility in Indian population
Vani, G. T., Mukesh, N., Badabagni, S. P., Devi, P. R., Prasad, M. H., Rani, P. U., & Reddy, P. P. (2009) · Clinica Chimica Acta · doi:10.1016/j.cca.2009.09.019 · Cited by 28 · see citing works
Cyclamate intake and cyclohexylamine excretion are not related to male fertility in humans
Serra‐Majem, L., Bassas, L., García-Glosas, R., Ribas, L., Inglés, C., Casals, I., Saavedra, P., & RENWICK, A. G. (2003) · Food Additives & Contaminants · doi:10.1080/02652030310001620450 · Cited by 28 · see citing works
Immunoglobulin in Seminal Fluid of Fertile, Infertile, Vasectomy and Vasectomy Reversal Patients
Fowler, J. E., & Mariano, M. (1983) · The Journal of Urology · doi:10.1016/s0022-5347(17)52403-9 · Cited by 28 · see citing works
Handelsman, D. J. (1997) · International Journal of Andrology · doi:10.1046/j.1365-2605.1997.00051.x · Cited by 27 · see citing works
Normal range and variation of the zona pellucida–induced acrosome reaction in fertile men
Liu, D. Y., Stewart, T. M., & Baker, H. W. G. (2003) · Fertility and Sterility · doi:10.1016/s0015-0282(03)00603-4 · Cited by 27 · see citing works
Positive Association of Sperm Dysfunction in the Pathogenesis of Recurrent Pregnancy Loss
Kavitha, P. (2014) · JOURNAL OF CLINICAL AND DIAGNOSTIC RESEARCH · doi:10.7860/jcdr/2014/9109.5172 · Cited by 26 · see citing works
Semen Quality Assessment in Fertile Men in Madrid During the Last 3 Decades
Otero, J., Medina‐Polo, J., García‐Gómez, B., Lora, D., Duarte-Ojeda, J. M., García-González, L., García‐Cruz, E., & Rodríguez-Antolín, A. (2015) · Urology · doi:10.1016/j.urology.2015.02.001 · Cited by 26 · see citing works
López-Teijón, M., Elbaile, M., & Álvarez, J. G. (2008) · Andrologia · doi:10.1111/j.1439-0272.2008.00862.x · Cited by 25 · see citing works
Ji, G., Yan, L., Liu, W., Huang, C., Gu, A., & Wang, X. (2013) · Reproduction · doi:10.1530/rep-12-0370 · Cited by 25 · see citing works
Paternal factors and embryonic development: Role in recurrent pregnancy loss
Dhawan, V., Kumar, M., Deka, D., Malhotra, N., Singh, N., Dadhwal, V., & Dada, R. (2018) · Andrologia · doi:10.1111/and.13171 · Cited by 25 · see citing works
Testicular volume and seminal fluid profile in fertile and infertile males in Ilorin, Nigeria
Ob, S., & Akiwumi, O. O. (1989) · International Journal of Gynecology & Obstetrics · doi:10.1016/0020-7292(89)90476-1 · Cited by 24 · see citing works
Ortiz, Á., Espino, J., Bejarano, I., Lozano, G. M., Monllor, F., García, J. F., Pariente, J. A., & Rodríguez, A. B. (2010) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-8-138 · Cited by 24 · see citing works
Spectrophotometric analysis of resazurin reduction test and semen quality in men.
Reddy, K. V. R., & Bordekar, A. D. (1999) · PubMed · Cited by 23 · see citing works
Onung, S. I., Young, E. E., Fasanmade, O. A., Chinedu., A. A., Brenda, N. C., & Ohwovoriole, A. E. (2017) · Current Diabetes Reviews · doi:10.2174/1573399813666170425152046 · Cited by 23 · see citing works
Tumor Necrosis Factor-α Gene Polymorphism Relationship to Seminal Variables in Infertile Men
Zalata, A. A. E.-K., Atwa, A., Badawy, A. E.-N., Aziz, A., Elbaz, R., Elhanbly, S. M., & Mostafa, T. (2013) · Urology · doi:10.1016/j.urology.2013.01.026 · Cited by 22 · see citing works
Primary antiphospholipid syndrome: morphofunctional penile abnormalities with normal sperm analysis
Rabelo-Júnior, C. N., de Carvalho, J. F., Gallinaro, A. L., Bonfá, E., Cocuzza, M., Saito, O. C., & Silva, C. (2011) · Lupus · doi:10.1177/0961203311422715 · Cited by 22 · see citing works
Valsa, J., Kp, S., Khan, P. S., Skandhan, K., Amith, S., & Gondalia, M. (2014) · Urologia Journal · doi:10.5301/urologia.5000039 · Cited by 21 · see citing works
Peptide and steroid hormone concentrations in human seminal plasma.
Rh, A., Eo, F., Tm, S.-K., & Pauerstein, C. J. (1984) · PubMed · Cited by 21 · see citing works
Effect of serum antioxidant levels on sperm function in infertile male
Palani, A. (2017) · Middle East Fertility Society Journal · doi:10.1016/j.mefs.2017.07.006 · Cited by 21 · see citing works
An andrological study of 51 fertile men
Åbyholm, T. (1981) · International Journal of Andrology · doi:10.1111/j.1365-2605.1981.tb00747.x · Cited by 20 · see citing works
Quality of 4-hourly ejaculates - levels of calcium and magnesium
Valsa, J., Kp, S., Gusani, P. H., Khan, P. S., & Amith, S. (2012) · Andrologia · doi:10.1111/j.1439-0272.2012.01301.x · Cited by 20 · see citing works
Assessment of male reproductive health by conventional method of semen analysis.
Khan, M. S., Deepa, F., Ahmed, Z., Tahir, F., & Khan, M. A. (2011) · PubMed · Cited by 20 · see citing works
Recio‐Vega, R., Calderón, E. H. O., Michel‐Ramirez, G., Martínez-Salinas, R. I., Gallegos‐Arreola, M. P., Ocampo‐Gómez, G., & Pérez–Morales, R. (2018) · International Archives of Occupational and Environmental Health · doi:10.1007/s00420-018-1320-9 · Cited by 20 · see citing works
Hormonal control of inhibin B in men
Giagulli, V. A., & Carbone, D. (2006) · Journal of Endocrinological Investigation · doi:10.1007/bf03344180 · Cited by 19 · see citing works
Vested, A., Ramlau‐Hansen, C. H., Bonde, J. ., Thulstrup, A. M., Kristensen, S. L., & Toft, G. V. (2011) · Asian Journal of Andrology · doi:10.1038/aja.2011.14 · Cited by 19 · see citing works
Increases in chromosome aberrations and in abnormal sperm morphology in rubber factory workers
Rendón, A., Armando Rojas, R., Fernández, S. I., & Pineda, I. (1994) · Mutation Research Letters · doi:10.1016/0165-7992(94)90027-2 · Cited by 18 · see citing works
Prazosin, an adrenergic blocking agent inadequate as male contraceptive pill
Kjærgaard, N., Kjærgaard, B., & Lauritsen, J. G. (1988) · Contraception · doi:10.1016/0010-7824(88)90008-x · Cited by 18 · see citing works
Flagged first, then by citations
2 of the 245 references couldn’t be matched to a known paper.
Research works printed but not linked: 6
- Ahmed FK, Memon AS, Khan AM, Burney I, Bano K. Effect of BMI on semen parameters in male infertility in tertiary care hospital of Karachi. Natl Editor Advis Board 2019;30:104.
- Azad N, Nazarian H, Nazari L, Novin MG, Piryaei A, Heidari MH, Farahani RM, Sadjadpour SS. Evaluation of PAWP and PLCf ex- pression in infertile men with previous ICSI fertilization failure. Urol J 2018;15:38-43.
- Culasso F, Lenzi A, Favilli S, Dondero F. Statistical analysis in androl- ogy. Arch Androl 1991;26:163-172.
- Kumar K, Venkatesh S, Sharma PR, Tiwari PK, Dada R DAZL 260A > G and MTHFR 677C > T variants in sperm DNA of infertile Indian men. Indian J Biochem Biophys 2011;48:422-426.
- Lee PA, Coughlin MT. Fertility after bilateral cryptorchidism. Evaluation by paternity, hormone, and semen data. Horm Res 2001;55:28-32.
- Stroup DF, Berlin JA, Morton SC, Olkin I, Williamson GD, Rennie D, Moher D, Becker BJ, Sipe TA, Thacker SB. Meta-analysis of obser- vational studies in epidemiology: a proposal for reporting. Meta- analysis Of Observational Studies in Epidemiology (MOOSE) group. JAMA 2000;283:2008-2012.
Cited by
Sorted by citations
Eisenberg, M. L., Esteves, S. C., Lamb, D. J., Hotaling, J. M., Giwercman, A., Hwang, K., & Cheng, Y.-S. (2023) · Nature Reviews Disease Primers · doi:10.1038/s41572-023-00459-w · Cited by 536 · see citing works
Detection and characterization of microplastics in the human testis and semen
Zhao, Q., Zhu, L., Weng, J., Jin, Z., Cao, Y., Jiang, H., & Zhang, Z. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.162713 · Cited by 506 · see citing works
Huang, B., Wang, Z., Kong, Y., Jin, M., & Ma, L. (2023) · BMC Public Health · doi:10.1186/s12889-023-16793-3 · Cited by 326 · see citing works
Hu, C. J., Garcia, M. A., Nihart, A. J., Liu, R., Yin, L., Adolphi, N. L., Gallego, D. F., Kang, H., Campen, M. J., & Yu, X. (2024) · Toxicological Sciences · doi:10.1093/toxsci/kfae060 · Cited by 239 · see citing works
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Montano, L., Giorgini, E., Notarstefano, V., Notari, T., Ricciardi, M., Piscopo, M., & Motta, O. (2023) · Science of The Total Environment · doi:10.1016/j.scitotenv.2023.165922 · Cited by 243 · see citing works
Fauser, B. C. J. M., Adamson, G. D., Boivin, J., Chambers, G. M., de Geyter, C., Dyer, S., Inhorn, M. C., Schmidt, L., Serour, G. I., Tarlatzis, B., et al. (2024) · Human Reproduction Update · doi:10.1093/humupd/dmad028 · Cited by 224 · see citing works
“1093 / hu m upd / d m ad028 / 751342 7 b y gue s t on 31 J anua r y 2024 and 1.6% in total sperm count, although the impact on TRF is yet unknown (Levine et al. , 2017; Jørgensen et al. , 2021; Levine et al. , 2023).”
BackgroundInfluentialLiang, Y., Huang, J., Zhao, Q., Mo, H., Su, Z., Feng, S., Li, S., & Ruan, X. (2024) · Human Reproduction · doi:10.1093/humrep/deae292 · Cited by 204 · see citing works
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Montano, L., Raimondo, S., Piscopo, M., Ricciardi, M., Guglielmino, A., Chamayou, S., Gentile, R., Gentile, M., Rapisarda, P., Conti, G. O., et al. (2025) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2025.117868 · Cited by 149 · see citing works
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Zhao, Q., Fang, Z., Wang, P., Qian, Z., Yang, Y., Ran, L., Zheng, J., Tang, Y., Cui, X., Li, Y., et al. (2025) · ACS Nano · doi:10.1021/acsnano.4c15112 · Cited by 116 · see citing works
Zhang, Y., Hou, B., Liu, T., Wu, Y., & Wang, Z. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115248 · Cited by 86 · see citing works
Sciorio, R., Tramontano, L., Adel, M., & Fleming, S. D. (2024) · Journal of Personalized Medicine · doi:10.3390/jpm14020198 · Cited by 75 · see citing works
Hu, Y., Shen, M., Wang, C., Huang, Q., Li, R., Dorj, G., Gombojav, E., Du, J., & Ren, L. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.133375 · Cited by 74 · see citing works
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Jonge, C. J. D., Barratt, C. L. R., Aitken, R. J., Anderson, R. A., Baker, P., Chan, D. Y. L., Connolly, M. P., Eisenberg, M. L., Garrido, N., Jørgensen, N., et al. (2024) · Human Reproduction Open · doi:10.1093/hropen/hoae017 · Cited by 75 · see citing works
Self-citationОсадчук, Л. В., Kleshchev, M. A., & Осадчук, А. В. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1255304 · Cited by 71 · see citing works
Aitken, R. J. (2024) · Frontiers in Reproductive Health · doi:10.3389/frph.2024.1364352 · Cited by 71 · see citing works
Saal, F. S. V., Antoniou, M. N., Belcher, S. M., Bergman, Å., Bhandari, R. K., Birnbaum, L. S., Cohen, A., Collins, T. J., DEMENEIX, B. A., Fine, A. M., et al. (2024) · Environmental Health Perspectives · doi:10.1289/ehp13812 · Cited by 56 · see citing works
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Kaltsas, A., Markou, E., Kyrgiafini, M.-A., Zikopoulos, A., Symeonidis, E. N., Dimitriadis, F., Zachariou, A., Sofikitis, N., & Chrisofos, M. (2025) · Genes · doi:10.3390/genes16010093 · Cited by 54 · see citing works
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Holmboe, S. A., Beck, A. L., Andersson, A., Main, K. M., Jørgensen, N., Skakkebæk, N. E., & Priskorn, L. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1343887 · Cited by 50 · see citing works
Self-citationPeng, Y., & Qi, H. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116505 · Cited by 51 · see citing works
Belmaker, I., Anca, E. D., Rubin, L. P., Magen-Molho, H., Miodovnik, A., & van der Hal, N. (2024) · Israel Journal of Health Policy Research · doi:10.1186/s13584-024-00628-6 · Cited by 56 · see citing works
Sciorio, R., Greco, P., Greco, E., Tramontano, L., Elshaer, F. M., & Fleming, S. D. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1545593 · Cited by 48 · see citing works
Kong, F., Fang, L., Gui, Y.-Y., Lan, H.-Y., Zhao, P.-P., Zhang, Y.-L., Jiang, L., Zhang, S.-Y., & Tong, X.-M. (2025) · ACS Nano · doi:10.1021/acsnano.5c00918 · Cited by 44 · see citing works
Hassine, M. B. H., Venditti, M., Rhouma, M. B., Minucci, S., & Messaoudi, I. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-26429-z · Cited by 46 · see citing works
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Hallberg, I., Björvang, R. D., Hadziosmanovic, N., Koekkoek, J. C., Pikki, A., van Duursen, M. B. M., Lenters, V. C., Sjunnesson, Y. C. B., Holte, J., Berglund, L., et al. (2023) · Journal of Exposure Science & Environmental Epidemiology · doi:10.1038/s41370-023-00579-1 · Cited by 43 · see citing works
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Vasseur, C., Serra, L., Balkhi, S. E., Lefort, G., Ramé, C., Froment, P., & Dupont, J. (2024) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2024.116410 · Cited by 41 · see citing works
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Ramsay, J. M., Fendereski, K., Horns, J. J., VanDerslice, J. A., Hanson, H. A., Emery, B. R., Halpern, J. A., Aston, K. I., Ferlic, E. A., & Hotaling, J. M. (2023) · Fertility and Sterility · doi:10.1016/j.fertnstert.2023.05.143 · Cited by 39 · see citing works
Xiong, Y.-W., Zhu, H.-L., Zhang, J., Geng, H., Tan, L., Zheng, X., Li, H., Fan, L.-L., Wang, X., Zhang, X.-D., et al. (2024) · Nature Communications · doi:10.1038/s41467-024-45675-4 · Cited by 38 · see citing works
Bouhadana, D., Pagé, M.-H. G., Montjean, D., Bélanger, M., Benkhalifa, M., Miron, P., & Petrella, F. (2025) · Antioxidants · doi:10.3390/antiox14081013 · Cited by 38 · see citing works
Zhang, Q., Xia, W., Zhou, X., Yang, C., Lu, Z., Wu, S., Lu, X., Yang, J., & Jin, C. (2023) · Environmental Pollution · doi:10.1016/j.envpol.2023.122723 · Cited by 38 · see citing works
Chen, W., Zou, H., Xu, H., Cao, R., Zhang, H., Zhang, Y., & Zhao, J. (2024) · Frontiers in Microbiology · doi:10.3389/fmicb.2024.1478082 · Cited by 39 · see citing works
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Gao, C., Sun, N., Xie, J., Li, J., Tao, L., Guo, L., Shi, L., He, X., Shen, X., Wang, H., et al. (2024) · Environment International · doi:10.1016/j.envint.2024.108571 · Cited by 32 · see citing works
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Cannarella, R., Curto, R., Condorelli, R. A., Lundy, S. D., Vignera, S. L., & Calogero, A. E. (2024) · Nature Communications · doi:10.1038/s41467-024-49765-1 · Cited by 33 · see citing works
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Salami, E. A., & Rotimi, O. A. (2024) · Toxicology Reports · doi:10.1016/j.toxrep.2024.101773 · Cited by 38 · see citing works
Cai, D., Li, J., Peng, Z., Fu, R., Chen, C., Liu, F., Li, Y., Su, Y., Li, C., & Chen, W. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms26083496 · Cited by 30 · see citing works
Venditti, M., Hassine, M. B. H., Messaoudi, I., & Minucci, S. (2023) · Frontiers in Cell and Developmental Biology · doi:10.3389/fcell.2023.1145702 · Cited by 30 · see citing works
Sánchez‐Resino, E., Marquès, M., Gutiérrez-Martín, D., Restrepo-Montes, E., Martínez, M. Á., Salas‐Huetos, A., Babió, N., Salas‐Salvadó, J., Gil‐Solsona, R., & Gago-Ferrero, P. (2023) · Environmental Science & Technology · doi:10.1021/acs.est.3c04347 · Cited by 28 · see citing works
Cipriani, S., Ricci, E. D., Chiaffarino, F., Esposito, G., Dalmartello, M., Vecchia, C. L., Negri, E., & Parazzini, F. (2023) · Andrology · doi:10.1111/andr.13396 · Cited by 29 · see citing works
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Advances in immunology of male reproductive toxicity induced by common environmental pollutants
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Li, T., Bian, B., Ji, R., Zhu, X., Wo, X., Song, Q., Li, Z., Wang, F., & Jia, Y. (2024) · Toxics · doi:10.3390/toxics12110779 · Cited by 27 · see citing works
Adverse outcome pathways of PBDEs inducing male reproductive toxicity
Zhang, Y., Xie, J., Ouyang, Y., Li, S., Sun, Y., Tan, W., Ren, L., & Zhou, X. (2023) · Environmental Research · doi:10.1016/j.envres.2023.117598 · Cited by 26 · see citing works
Zaman, F., Hassan, M., Khattak, W. A., Ali, A., Awad, M. F., & Chen, F. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.176960 · Cited by 29 · see citing works
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Liu, H., Du, X., Zhang, Z., Ge, K., Chen, X., Losiewicz, M. D., Guo, H., & Zhang, H. (2024) · Environment International · doi:10.1016/j.envint.2024.108771 · Cited by 25 · see citing works
Dietary trends and the decline in male reproductive health
Whittaker, J. (2023) · HORMONES · doi:10.1007/s42000-023-00431-z · Cited by 25 · see citing works
Li, Y., Lu, T., Wu, Z., Wang, Z., Yu, T., Wang, H., Tang, C., & Zhou, Y. (2023) · Frontiers in Endocrinology · doi:10.3389/fendo.2023.1194455 · Cited by 25 · see citing works
Ambient fine particulate matter constituents and semen quality among adult men in China
Zhang, Y., Wei, J., Zhao, S., Zeng, Q., Sun, S., & Cao, W. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.133313 · Cited by 24 · see citing works
RetractedWang, T., Wang, Q., Fan, Z., Xu, R., Deng, X., Li, Y., Liang, S., Lv, Z., Huang, S., Duan, Y., et al. (2023) · Andrology · doi:10.1111/andr.13471 · Cited by 23 · see citing works
Venditti, M., Romano, M. Z., Boccella, S., Haddadi, A., Biasi, A., Maione, S., & Minucci, S. (2024) · Frontiers in Endocrinology · doi:10.3389/fendo.2024.1399256 · Cited by 24 · see citing works
Grechi, N., Ferronato, G. A., Devkota, S., & Ferraz, M. D. A. M. M. (2024) · Biology of Reproduction · doi:10.1093/biolre/ioae154 · Cited by 22 · see citing works
Han, X., & Jin, X. (2025) · Frontiers in Endocrinology · doi:10.3389/fendo.2025.1573526 · Cited by 32 · see citing works
Cai, X., Ni, H., Wang, Q., Dai, T., Wang, L., Song, C., Li, Y., Li, F., Meng, T., Sheng, H., et al. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.132330 · Cited by 22 · see citing works
Yan, Z., Zhong, X., Chen, L., Gong, L., Luo, L., He, Q., Zhu, L., & Tian, K. (2023) · Ecotoxicology and Environmental Safety · doi:10.1016/j.ecoenv.2023.115626 · Cited by 22 · see citing works
Endocrine disruption and male reproductive disorders: unanswered questions
Sharpe, R. M. (2024) · Human Reproduction · doi:10.1093/humrep/deae143 · Cited by 22 · see citing works
Tombul, O. K., Akdağ, A. D., Thomas, P. B., & Kaluç, N. (2025) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2025.117235 · Cited by 21 · see citing works
Ali, W., Deng, K., Sun, J. G., Ma, Y., Liu, Z., & Zou, H. (2023) · Environmental Science and Pollution Research · doi:10.1007/s11356-023-29548-9 · Cited by 21 · see citing works
Male Infertility: A Comprehensive Review of Urological Causes and Contemporary Management
Barone, B., Amicuzi, U., Tammaro, S., Olivetta, M., Stizzo, M., Musone, M., Napolitano, L., Luca, L. D., Reccia, P., Capone, F., et al. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15010397 · Cited by 20 · see citing works
He, J., Li, J., Li, Y., Xu, Z., Ma, M., Chen, H., Chen, P., Lv, L., Shang, X., & Liu, G. (2024) · Aging · doi:10.18632/aging.205538 · Cited by 20 · see citing works
Pathophysiological effects of hypoxia on testis function and spermatogenesis
Lord, T. (2025) · Nature Reviews Urology · doi:10.1038/s41585-024-00969-6 · Cited by 22 · see citing works
Ren, Y., Li, Z., Chen, K., Zhang, H., Liang, Q., Li, Y., Liu, B., & Wang, L. (2025) · Environmental Science & Technology · doi:10.1021/acs.est.5c03589 · Cited by 21 · see citing works
Sharma, A., Papanikolaou, N., Sherif, S. A., Dimakopolou, A., Thaventhiran, T., Go, C., Entwistle, O. H., Brown, A. C., Luo, R., Jha, R., et al. (2023) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgad523 · Cited by 20 · see citing works
Zhang, Y., Shi, W., Zhang, M., Lufei, X., Wu, L., Li, C., Zhang, Z., Cao, W., Zhang, J., Zeng, Q., et al. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.132602 · Cited by 19 · see citing works
Garrido, N., & Juliá, M. G. (2024) · Biology · doi:10.3390/biology13010030 · Cited by 19 · see citing works
Effects of temperature anomaly on sperm quality: A multi-center study of 33,234 men
Xiao, L., Wang, Q., Ni, H., Xu, T. S., Cai, X., Dai, T., Wang, L., Song, C., Li, Y., Li, F., et al. (2024) · Heliyon · doi:10.1016/j.heliyon.2024.e26765 · Cited by 19 · see citing works
Chen, T., Zhang, B., He, G., Wang, N., Cao, M., Shen, C., Chen, X., Chen, L., Liu, K., Luo, Y., et al. (2024) · Advanced Science · doi:10.1002/advs.202310110 · Cited by 18 · see citing works
Yu, P., Zhao, X. Y., Zhou, D., Wang, S., Hu, Z., Lian, K., Zhang, N. Y. X., & Duan, P. (2025) · Cell Biology and Toxicology · doi:10.1007/s10565-025-10006-w · Cited by 19 · see citing works
Jiang, B., Yang, D., & Peng, H. (2024) · Biology of Reproduction · doi:10.1093/biolre/ioae126 · Cited by 18 · see citing works
Kumar, N., & Mangla, M. (2025) · Biology of Reproduction · doi:10.1093/biolre/ioaf054 · Cited by 18 · see citing works
Chamayou, S., Giacone, F., Cannarella, R., & Guglielmino, A. (2023) · Journal of Clinical Medicine · doi:10.3390/jcm12020671 · Cited by 18 · see citing works
Ellis, L. B., Molina, K., Robbins, C. R., Freisthler, M. S., Sgargi, D., Mandrioli, D., & Perry, M. J. (2023) · Environmental Health Perspectives · doi:10.1289/ehp12678 · Cited by 16 · see citing works
Kiwitt-Cárdenas, J., Árense-Gonzalo, J. J., Adoamnei, E., Sarabia‐Cos, L., Vela-Soria, F., Fernández, M. F., Gosálvez, J., Mendiola, J., & Torres-Cantero, A. M. (2023) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2023.169314 · Cited by 18 · see citing works
Self-citationCheng, A., Luo, H., Fan, B., Xiang, Q., Nie, Z., Feng, S., Qiao, Y., Wu, Y., Zhu, Q., Liu, R., et al. (2024) · The Science of The Total Environment · doi:10.1016/j.scitotenv.2024.172036 · Cited by 18 · see citing works
RetractedAssociation between semen microbiome disorder and sperm DNA damage
He, J., Ma, M., Xu, Z., Guo, J., Chen, H., Yang, X., Chen, P., & Liu, G. (2024) · Microbiology Spectrum · doi:10.1128/spectrum.00759-24 · Cited by 18 · see citing works
Wu, H., Kalia, V., Manz, K. E., Chillrud, L., Dishon, N. H., Jackson, G. L., Dye, C. K., Orvieto, R., Aizer, A., Levine, H., et al. (2024) · Environmental Science & Technology · doi:10.1021/acs.est.3c10314 · Cited by 18 · see citing works
Self-citationAkhigbe, R. E., Oyedokun, P. A., Akhigbe, T. M., Hamed, M. A., Fidelis, F. B., Omole, A. I., Adeogun, A. E., Akangbe, M. D., & Oladipo, A. A. (2024) · Biochemistry and Biophysics Reports · doi:10.1016/j.bbrep.2024.101889 · Cited by 20 · see citing works
Reproductive toxicity of micro‐ and nanoplastics: Insights from experimental and human studies
Wehrli, L., Martin, O., Trasande, L., & Damdimopoulou, P. (2025) · Journal of Internal Medicine · doi:10.1111/joim.70038 · Cited by 17 · see citing works
Grau, E. G., Lleberia, J., Costa, L., Guitart, M., Yeste, M., Benet, J., Amengual, M. J., & Ribas‐Maynou, J. (2022) · Biology · doi:10.3390/biology12010070 · Cited by 17 · see citing works
Ligny, W. R. D., Fleischer, K., Grens, H., Braat, D. D. M., & de Bruin, J. P. (2023) · Human Reproduction Open · doi:10.1093/hropen/hoad020 · Cited by 17 · see citing works
Could the sperm epigenome become a diagnostic tool for evaluation of the infertile man?
Caroppo, E., & Skinner, M. K. (2023) · Human Reproduction · doi:10.1093/humrep/dead266 · Cited by 17 · see citing works
Product collaborative filtering based recommendation systems for large-scale E-commerce
Trinh, T., Nguyen, V.-H., Nguyen, N., & Nguyen, D.-N. (2025) · International Journal of Information Management Data Insights · doi:10.1016/j.jjimei.2025.100322 · Cited by 17 · see citing works
Zhang, Q., Guo, P., Zhou, X., Yang, C., Lu, Z., Wu, S., Lu, X., Yang, J., & Jin, C. (2025) · Free Radical Biology and Medicine · doi:10.1016/j.freeradbiomed.2025.05.402 · Cited by 16 · see citing works
Role of Redox-Induced Protein Modifications in Spermatozoa in Health and Disease
Onochie, C., Evi, K., & O’Flaherty, C. (2025) · Antioxidants · doi:10.3390/antiox14060720 · Cited by 16 · see citing works
Zhang, M., Liu, X., Deng, Y.-L., Liu, C., Zeng, J.-Y., Miao, Y., Wu, Y., Li, C., Li, Y.-J., Li, Y.-J., et al. (2023) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2023.132638 · Cited by 16 · see citing works
Venishetty, N., Alkassis, M., & Raheem, O. A. (2024) · Uro · doi:10.3390/uro4020003 · Cited by 19 · see citing works
Climate change, microplastics, and male infertility
Daniels, D., & Eberhardt, A. B. (2024) · Current Opinion in Urology · doi:10.1097/mou.0000000000001201 · Cited by 16 · see citing works
- Authors
- Levine, H., Jørgensen, N., Martino-Andrade, A., Mendiola, J., Weksler-Derri, D., Jolles, M., Pinotti, R., & Swan, S. H.
- Affiliations
- Hebrew University of Jerusalem (IL)
- University of Copenhagen (DK)
- Department of Physiology, Federal University of Parana , Curitiba, Brazil
- Instituto Murciano de Investigación Biosanitaria (ES)
- Ben-Gurion University of the Negev (IL)
- Icahn School of Medicine at Mount Sinai (US)
- Corresponding author
- Levine, Hagai
- ORCID
- Venue
- Human Reproduction Update
- Publisher
- Oxford University Press (OUP)
- Published
- 2022-11-15
- Volume
- 29
- Issue
- 2
- Pages
- 157-176
- ISSN
- 1355-4786 (ISSN-L)
- 1460-2369
- OpenAlex
- W4309099580
- Cited by
- 728
- References
- 245
- Citations by year
- 2026: 206 · 2025: 205 · 2024: 183 · 2023: 130 · 2022: 3 · 2020: 1
- FWCI
- 21.07
- Type
- journal article
- Language
- en
- Open access
- bronze
- doi.org
- Locations
- Human Reproduction Update (publishedVersion)
- PubMed (publishedVersion)
- Hispana (publishedVersion)
- Funders
- The Grantham Foundation for the Protection of the Environment
- National Council for Scientific and Technological Development
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Health Professions › General Health Professions › Male Reproductive Health Studies
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Keywords
- sperm count, total sperm count, semen quality, male reproductive health, temporal trends, fertility status, semen volume, sperm concentration, meta-regression, Central and South America, Asia and Africa, 20th-21st century, lifestyle factors, reproductive toxicants
- MeSH terms
- Humans, Male, Regression Analysis, Semen, Sperm Count, Sperm Motility, Spermatozoa, Semen Analysis
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