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Cited by 125Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesOvarian function and disordersSexual Differentiation and Disorders

The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.

AMH as Predictor of Premature Ovarian Insufficiency: A Longitudinal Study of 120 Turner Syndrome Patients

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Lunding, Stine Aa., Aksglaede, Lise, Anderson, Richard A., Main, Katharina M., Juul, Anders, Hagen, Casper P., Pedersen, Anette T.·2015·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.2015-1621
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Abstract

CONTEXT: The majority of Turner syndrome (TS) patients suffer from accelerated loss of primordial follicles. Low circulating levels of anti-Müllerian hormone (AMH) may predict the lack of spontaneous puberty in prepubertal girls and imminent premature ovarian insufficiency (POI) in TS women with preserved ovarian function. OBJECTIVES: To evaluate the association between circulating AMH and ovarian status in TS patients. DESIGN: Longitudinal observational cohort study. SETTING: Tertiary referral center for pediatric and gynecologic endocrinology. PARTICIPANTS: A total of 120 TS patients, aged 0 to 48 years. MAIN OUTCOME MEASURES: Longitudinal measurements of AMH, FSH, LH, estradiol, and inhibin B according to age, karyotype (45,X; 45,X/46,XX mosaicism; miscellaneous karyotypes), and ovarian status (group 0, prepubertal; group 1, never ovarian function; group 2, ongoing ovarian function; and group 3, loss of ovarian function). RESULTS: Ovarian status was highly associated with the TS karyotype: spontaneous puberty—45,X (three of 44 patients), 45,X/46,XX (15 of 17), miscellaneous (17 of 42); and POI—45,X (three of three), 45,X/46,XX (one of 15), and miscellaneous (eight of 17). AMH was associated with ovarian status (eg, group 1, <2 pmol/L; vs group 2, 19 pmol/L; P < .001). AMH < 4 pmol/L (corresponding to <-2 SD) predicted absent puberty in prepubertal girls and POI in adolescent and adult patients. CONCLUSION: The majority of women with mosaic karyotype 45,X/46,XX had ongoing ovarian function in early adulthood. AMH < -2 SD predicted failure to enter puberty in young TS girls and imminent POI in adolescent and adult TS patients.

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Metadata

Authors
Lunding, S. A., Aksglaede, L., Anderson, R. A., Main, K. M., Juul, A., Hagen, C. P., & Pedersen, A. T.
Affiliations
University of Copenhagen (DK)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
2015-07
Volume
100
Issue
7
Pages
E1030-E1038
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jc.2015-1621
OpenAlex
W1955703337
Cited by
125
References
42
Citations by year
2026: 8 · 2025: 16 · 2024: 14 · 2023: 12 · 2022: 13 · 2021: 11 · 2020: 13 · 2019: 10 · 2018: 9 · 2017: 12 · 2016: 5 · 2015: 2
FWCI
6.38
Type
journal article
Language
en
Open access
Licence
other-oa
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
  • Research at the University of Copenhagen (University of Copenhagen) (submittedVersion)
  • Edinburgh Research Explorer (University of Edinburgh) (submittedVersion, other-oa)
Funders
  • Gentofte Hospital
  • Rigshospitalet
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords
Turner syndrome, anti-Müllerian hormone, premature ovarian insufficiency, ovarian function, karyotype, 45,X/46,XX mosaicism, spontaneous puberty, primordial follicle loss, inhibin B, follicle-stimulating hormone, estradiol
MeSH terms
Adolescent, Adult, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Longitudinal Studies, Middle Aged, Prognosis, Turner Syndrome, Biomarkers, Primary Ovarian Insufficiency, Anti-Mullerian Hormone, Young Adult

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