The DOI matches its Crossref record; 38 of the 39 references it cites were found in a registry or an index.
The Efficacy and Adverse Events of Testosterone Replacement Therapy in Hypogonadal Men: A Systematic Review and Meta-Analysis of Randomized, Placebo-Controlled Trials
Abstract
CONTEXT: The efficacy and safety of testosterone replacement therapy (TRT) in hypogonadal men remain incompletely understood. OBJECTIVE: To conduct a systematic review and meta-analysis of randomized clinical trials (RCT) to determine the effects of TRT on patient-important outcomes and adverse events in hypogonadal men. DATA SOURCES: We searched Ovid MEDLINE, Ovid EMBASE, Ovid Cochrane Database of Systematic Reviews, Ovid Cochrane Central Register of Controlled Trials, and Scopus from inception to March 2th, 2017. STUDY SELECTION: RCTs that assessed the efficacy and adverse events of TRT of at least 12 weeks compared with placebo in adult men with hypogonadism, defined by morning testosterone ≤300 ng/dL and at least one symptom or sign of hypogonadism. DATA EXTRACTION: Reviewers working independently and in duplicate assessed the quality of the trials and collected data on patient characteristics, interventions, and outcomes. DATA SYNTHESIS: We found 11 publications, reporting on 4 eligible trials (including 1,779 patients) at low risk of bias. Compared to placebo, TRT was associated with a small but significant increase in sexual desire or libido [standardized mean difference (SMD): 0.17, 95% CI 0.01, 0.34] (n=1383), erectile function [SMD: 0.16, 95% CI 0.06, 0.27] (n=1344), and sexual satisfaction [SMD: 0.16, 95% CI 0.01, 0.31] (n=676), but had no effect on energy or mood. TRT was associated with an increased risk of developing erythrocytosis [relative risk: 8.14, 95% CI: 1.87, 35.40] (n=1579) compared to placebo, but had no significant effect on lower urinary tract symptoms (LUTS). CONCLUSION: In hypogonadal men TRT improves sexual desire, erectile function, and sexual satisfaction, however it increases the risk of erythrocytosis.
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“Despite the fact that the prevalence of FH in obese male population is increased by 13-fold (8), the impact of liraglutide on obesity-related FH has not yet been addressed in a prospective clinical study.”
From Effects of liraglutide on obesity-associated functional hypogonadism in men (2019) · cites this paper as [8]
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“It has been reported previously that LH increased with WR in magnitude-dependent manner (8).”
From Effects of liraglutide on obesity-associated functional hypogonadism in men (2019) · cites this paper as [8]
In the citing paper
“With weight loss of more than 15% LH increased for 2.2 IU (8).”
From Effects of liraglutide on obesity-associated functional hypogonadism in men (2019) · cites this paper as [8]
Citations
Cites
Statistical Power Analysis for the Behavioral Sciences
Muller, K. E., & Cohen, J. (1989) · Technometrics · doi:10.2307/1270020 · Cited by 99,603
Statistical power analysis for the behavioral sciences
Cohen, J. (1990) · Computers Environment and Urban Systems · doi:10.1016/0198-9715(90)90050-4 · Cited by 65,417
Measuring inconsistency in meta-analyses
Higgins, J. P. T., Thompson, S. G., Deeks, J. J., & Altman, D. G. (2003) · BMJ · doi:10.1136/bmj.327.7414.557 · Cited by 63,139
Liberati, A., Altman, D. G., Tetzlaff, J., Mulrow, C., Gøtzsche, P. C., Ioannidis, J. P. A., Clarke, M., Devereaux, P. J., Kleijnen, J., & Moher, D. (2009) · PLoS Medicine · doi:10.1371/journal.pmed.1000100 · Cited by 28,164
Cochrane Handbook for Systematic Reviews of Interventions: Cochrane Book Series
(2008) · doi:10.1002/9780470712184 · Cited by 25,048
Rosen, R. C., Riley, A., Wagner, G., Osterloh, I. H., Kirkpatrick, J., & Mishra, A. (1997) · Urology · doi:10.1016/s0090-4295(97)00238-0 · Cited by 5,849
Bhasin, S., Cunningham, G. R., Hayes, F. J., Matsumoto, A. M., Snyder, P. J., Swerdloff, R. S., & Montori, V. M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2354 · Cited by 1,954
Self-citationEffects of Testosterone Treatment in Older Men
Snyder, P. J., Bhasin, S., Cunningham, G. R., Matsumoto, A. M., Stephens-Shields, A. J., Cauley, J. A., Gill, T. M., Barrett-Connor, E., Swerdloff, R. S., Wang, C., et al. (2016) · New England Journal of Medicine · doi:10.1056/nejmoa1506119 · Cited by 890
Self-citationCalof, O. M., Singh, A. B., Lee, M. L., Kenny, A. M., Urban, R. J., Tenover, J. L., & Bhasin, S. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.11.1451 · Cited by 728
Self-citationAdverse Effects of Testosterone Therapy in Adult Men: A Systematic Review and Meta-Analysis
Fernández-Balsells, M. M., Murad, M. H., Lane, M., Lampropulos, J. F., Albuquerque, F., Mullan, R. J., Agrwal, N., Elamin, M. B., Gallegos-Orozco, J. F., Wang, A. T., et al. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2575 · Cited by 713
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Items 101–148 of 148
Payne, H. A., McMenemin, R. M., Bahl, A. K., Greene, D. R., & Staffurth, J. N. (2018) · International Journal of Clinical Practice · doi:10.1111/ijcp.13292 · Cited by 3
Testosterone therapy: a friend or a foe for the aging men with benign prostatic hyperplasia?
Maggi, M., Rastrelli, G., & Vignozzi, L. (2019) · Asian Journal of Andrology · doi:10.4103/aja.aja_86_19 · Cited by 3
Nolan, B. J., Proietto, J., & Sumithran, P. (2022) · American Journal of Medical Genetics Part A · doi:10.1002/ajmg.a.62770 · Cited by 3
Nieschlag, E., & Behre, H. M. (2023) · Springer Reference Medizin · doi:10.1007/978-3-662-61901-8_36 · Cited by 2
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Смирнов, В. В., Шаповалова, А. Б., Василенко, В. С., Мочалов, П. А., Barkhatov, A. A., Gogoleva, T. A., Файзуллина, Р. Р., & Борисович, В. П. (2025) · Медицина: теория и практика · doi:10.56871/mtp.2025.56.67.004 · Cited by 2
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Shores, M. M. (2020) · Springer eBooks · doi:10.1007/978-3-030-54482-9_12 · Cited by 2
Chandra, M. S., Wang, C., Gagliano‐Jucá, T., Gaikwad, E., Shang, Y. V., Pencina, K. M., & Bhasin, S. (2026) · Endocrine Practice · doi:10.1016/j.eprac.2026.01.019 · Cited by 1
Self-citationAbadom, M., Nyong, E., Hernandez, B. S., Saffati, G., Parikh, N. N., & Khera, M. (2026) · Sexual Medicine Reviews · doi:10.1093/sxmrev/qeag024 · Cited by 1
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Tatachar, A., & Gibson, C. M. (2019) · Side effects of drugs annual · doi:10.1016/bs.seda.2019.06.003 · Cited by 1
Morgentaler, A., Lodaya, K. J., Telang, S., Hayashida, D. K., & Hu, Y. (2022) · Androgens Clinical Research and Therapeutics · doi:10.1089/andro.2021.0024 · Cited by 1
Yassin, A. A. (2022) · Current Trends in Internal Medicine · doi:10.29011/2638-003x.100061 · Cited by 1
Nieschlag, E., & Behre, H. M. (2023) · Springer eBooks · doi:10.1007/978-3-031-31574-9_36 · Cited by 1
Vargas‐Ortega, G., Pérez-Villarreal, G., de Santiago, A. R., Balcázar‐Hernández, L., Mendoza‐Zubieta, V., Landa-Gutierrez, O., Estrada-Robles, C., & González‐Virla, B. (2019) · International Journal of Endocrinology · doi:10.1155/2019/2356580 · Cited by 1
Alger, M., Luera, N. A., & Weiner, R. (2021) · Evidence-Based Practice · doi:10.1097/ebp.0000000000001307 · Cited by 1
Волкова, Н. И., Сафроненко, А. В., Ганцгорн, Е. В., & Degtyareva, Y. S. (2022) · Obesity and metabolism · doi:10.14341/omet12850 · Cited by 1
A lifestyle intervention to improve outcomes in men with castrate-resistant prostate cancer
Greasley, R. (2018) · Sheffield Hallam University · doi:10.7190/shu-thesis-00165
Erythrocytosis in Patients on Testosterone Therapy
Desai, A. P., & Go, R. S. (2021) · Springer eBooks · doi:10.1007/978-3-030-77111-9_2
Неспецифический реактивный гепатит у больных желчнокаменной болезнью
Бычков, С. А. (2007) · Electronic Kharkiv National University Institutional Repository (Kharkiv National University)
Benefits of Testosterone Treatment
Basaria, S. S., & Gagliano‐Jucá, T. (2022) · doi:10.1093/med/9780198870197.003.0489
Risks of Testosterone Treatment
Dobs, A. S., & Yalamanchi, S. (2022) · doi:10.1093/med/9780198870197.003.0490
Dhindsa, S. (2022) · Wiley eBooks · doi:10.1002/9781119484288.ch85
Nieschlag, E., & Behre, H. M. (2021) · Springer Reference Medizin · doi:10.1007/978-3-662-61904-9_36-1
Benefits and Risks of Testosterone Replacement in the Older Man with Hypogonadism
Marcelli, M., & Mediwala, S. N. (2022) · Springer eBooks · doi:10.1007/978-3-030-99918-6_30
Male Hypogonadism and Aging: An Update
Iglesias, P., Núñez, A., & Díez, J. J. (2023) · Springer eBooks · doi:10.1007/978-3-031-31501-5_9
Grossmann, M., Robledo, K. P., Daniel, M., Handelsman, D. J., Inder, W. J., Stuckey, B. G. A., Yeap, B. B., Fui, M. N. T., Bracken, K., Allen, C., et al. (2023) · SSRN Electronic Journal · doi:10.2139/ssrn.4660402
Definition, epidemiology, and implications of male infertility
Chung, E. (2024) · Elsevier eBooks · doi:10.1016/b978-0-323-93047-5.00010-6
Sepah, S. C., Alizaidy, G., Henry, H., & Boerger, N. (2024) · doi:10.31219/osf.io/nbkda
Characteristics of depression treatment in men with testosterone deficiency
Osadshiy, Y. Y., & Soldatkina, S. V. (2024) · Neurology Bulletin · doi:10.17816/nb628936
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Iglesias, P., Núñez, A., & Díez, J. J. (2024) · Springer eBooks · doi:10.1007/978-3-031-65245-5_9
Reproductive and nonreproductive actions of testosterone
Gagliano‐Jucá, T., Jain, A., Jasuja, R., & Bhasin, S. (2025) · Elsevier eBooks · doi:10.1016/b978-0-443-13825-6.00198-9
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DeMilt, G. N. (2025) · Lynchburg Journal of Medical Science · doi:10.63932/3067-7106.1006
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Grutman, A. J., Su, Z. T., & Herati, A. S. (2025) · Springer eBooks · doi:10.1007/978-3-031-96376-6_31 · Cited by 1
Leydig Cell Function in Obesity and Diabetes
Grossmann, M. (2025) · Springer eBooks · doi:10.1007/978-3-031-96376-6_34
Why are young men ‘T maxxing’ testosterone? Do they need it? And what are the risks?
Cornell, S., Piatkowski, T. M., & Cox, L. T. J. (2025) · doi:10.64628/aa.xhjhsgrn9
Lavecchia, A., Virgilio, C. D., Manzari, C., Giudice, C. L., Pousis, C., Zupa, R., Mylonas, C. C., Picardi, E., Ventriglia, G., Pesole, G., et al. (2025) · Animal Reproduction Science · doi:10.1016/j.anireprosci.2025.108024
Testosterone Replacement Therapy: Indications, Application Protocols, and Side Effect Profile
Demir, E., & Akpınar, E. (2026) · Recent trends in pharmacology. · doi:10.62425/rtpharma.1829150
Chehadeh, C., Nayar, K. H., Alegre, D., Auerbach, M. H., & Rappaport, D. E. (2026) · JEM Reports · doi:10.1016/j.jemrpt.2026.100231
Newman, M. S., Smeaton, J., Gillson, G., & Jaferi, A. (2026) · Frontiers in Reproductive Health · doi:10.3389/frph.2026.1804311
Szczupak, M., Kobak, J., Kreczko, M. J., Wierzchowska, J., & Krupa-Nurcek, S. (2026) · Frontiers in Endocrinology · doi:10.3389/fendo.2026.1801055
Han, W., Stump, K., Gubara, K., Gottipati, P., Aynaszyan, S., & Pazionis, T. J. C. (2026) · Global Spine Journal · doi:10.1177/21925682261487188
Nguyen, H. T., Nguyen, A. L. K., Tran, C. Q., Dam, C. V., Nguyen, T. H., & Nguyen, T. K. (2026) · Andrologia · doi:10.1155/and/8818332
Siqueira, T. D. S., Sousa, H. K. P., & de Queiroz, R. R. (2026) · medRxiv · doi:10.64898/2026.09.27.26364129
Metadata
- Authors
- Ponce, O. J., Spencer-Bonilla, G., Alvarez-Villalobos, N., Serrano, V., Singh-Ospina, N., Rodriguez-Gutierrez, R., Salcido-Montenegro, A., Benkhadra, R., Prokop, L. J., Bhasin, S., & Brito, J. P.
- Affiliations
- Mayo Clinic (US)
- Knowledge and Evaluation Research Unit, Division of Endocrinology, Diabetes, Metabolism and Nutrition, Department of Medicine, Mayo Clinic, Rochester, Minnesota
- Division of Endocrinology, Diabetes and Metabolism, University of Florida, Gainesville, Florida
- Universidad Autonoma de Nuevo Leon, Hospital Universitario “Dr. José E. Gonzalez,” Plataforma INVEST-KER Mexico, Monterrey, Nuevo León, México
- Brigham and Women's Hospital (US)
- Corresponding author
- Brito, Juan P
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2018-03-17
- Volume
- 103
- Issue
- 5
- Pages
- 1745-1754
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2792321631
- Cited by
- 148
- References
- 39
- Citations by year
- 2026: 11 · 2025: 13 · 2024: 12 · 2023: 18 · 2022: 24 · 2021: 22 · 2020: 14 · 2019: 20 · 2018: 13
- FWCI
- 2.65
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Health Sciences › Medicine › Psychiatry and Mental health › Sexual function and dysfunction studies
- Keywords
- testosterone replacement therapy, male hypogonadism, sexual desire, erectile function, sexual satisfaction, erythrocytosis, lower urinary tract symptoms, adverse events
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