The DOI matches its Crossref record; 14 of the 14 references it cites were found in a registry or an index.
Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency.
Abstract
Little information is available on cardiac involvement in GH-deficient adults. Thus, we evaluated cardiac structure and function by means of one- and two-dimensional echocardiography in 11 adult patients [3 women and 8 men; mean age, 27.2 +/- 3.8 (+/- SD) yr] affected with GH deficiency. Twelve age- and sex-matched normal subjects served as the control group. All patients had been treated with extractive GH over 9 yr, and therapy withdrawal had been performed at least 3 yr before entering the study. GH-deficient patients had significantly lower values of interventricular septum (7.1 +/- 1 vs. 9 +/- 0.4 mm; P < 0.01) and left ventricular posterior wall thickness (6.1 +/- 1 vs. 9 +/- 0.4 mm; P < 0.01), which resulted in a significantly smaller left ventricular mass index (54 +/- 11 vs. 85 +/- 15 g/m2; P < 0.001). The left ventricular end-diastolic and end-systolic diameters did not differ significantly after correction for body area surface, whereas ejection phase indices showed lower values, with a fractional shortening of 34 +/- 4% vs. 38 +/- 5% (P < 0.05) and an ejection fraction of 59 +/- 9% vs. 69 +/- 10% (P < 0.05). In conclusion, the results of this study demonstrate the involvement of cardiac muscle in patients affected with GH deficiency.
Overview
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“GH deficiency is associated with reduced lean body mass (53), decreased exercise capacity (54), impaired cardiac function (55), and reduction in bone mineral density (56), which may be of particular significance in immobilized patients, as well as sleep disturbances, social isolation, reduced physical mobility, and general well-being (57).”
From Anterior Pituitary Dysfunction in Survivors of Traumatic Brain Injury (2004) · cites this paper as [53]
Citations
Cites
Salomon, F., Cuneo, R. C., Hesp, R., & Sönksen, P. H. (1989) · New England Journal of Medicine · doi:10.1056/nejm198912283212605 · Cited by 1,326
BENEFICIAL EFFECTS OF GROWTH HORMONE TREATMENT IN GH-DEFICIENT ADULTS
Jørgensen, J. O. L., Thuesen, L., Ingemann-Hansen, T., Pedersen, S. A., Jørgensen, I., Skakkebaek, N. E., & Christiansen, J. S. (1989) · The Lancet · doi:10.1016/s0140-6736(89)92328-3 · Cited by 890
Quinones, M. A., Waggoner, A. D., Reduto, L. A., Nelson, J. G., Young, J. B., Winters, W. L., Ribeiro, L. G., & Miller, R. R. (1981) · Circulation · doi:10.1161/01.cir.64.4.744 · Cited by 735
Devereux, R. B. (1987) · Hypertension · doi:10.1161/01.hyp.9.2_pt_2.ii19 · Cited by 550
Guler, H. P., Zapf, J., Scheiwiller, E., & Froesch, E. R. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.13.4889 · Cited by 422
ORAL CLONIDINE AS A GROWTH HORMONE STIMULATION TEST
Gil‐Ad, I., Topper, E., & Laron, Z. (1979) · The Lancet · doi:10.1016/s0140-6736(79)90293-9 · Cited by 197
Skeletal Muscle Performance in Adults with Growth Hormone Deficiency
Cuneo, R. C., Salomon, F., Wiles, M., & Sönksen, P. H. (2008) · Hormone Research · doi:10.1159/000181585 · Cited by 135
Evidence for biventricular involvement in acromegaly: a Doppler echocardiographic study
Fazio, S., Cittadini, A., Sabatini, D., Merola, B., Colao, A., Biondi, B., Lombardi, G., & Saccà, L. (1993) · European Heart Journal · doi:10.1093/eurheartj/14.1.26 · Cited by 125
Self-citationGrowth hormone in the regulation of hyperlipidemia
Blackett, P. R., WEECH, P. K., McConathy, W. J., & Fesmire, J. D. (1982) · Metabolism · doi:10.1016/0026-0495(82)90121-4 · Cited by 81
Guse, A. H., Kiess, W., Funk, B., Kessler, U., Berg, I., & Gercken, G. (1992) · Endocrinology · doi:10.1210/en.130.1.145 · Cited by 78
Cited by
Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review
Carroll, P. V., Christ the members of Growth Hormon, E. R., Bengtsson, B. Å., Carlsson, L., Christiansen, J. S., Clemmons, D., Hintz, R., Ho, K., Laron, Z., Sizonenko, P., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.2.4594 · Cited by 822
The Diagnosis of Growth Hormone Deficiency in Children and Adults
Shalet, S. M., Toogood, A., Rahim, A., & Brennan, B. M. D. (1998) · Endocrine Reviews · doi:10.1210/edrv.19.2.0329 · Cited by 414
Anterior Pituitary Dysfunction in Survivors of Traumatic Brain Injury
Agha, A., Rogers, B., Sherlock, M., O’Kelly, P., Tormey, W., Phillips, J., & Thompson, C. J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0511 · Cited by 390
Mortality in Patients with Pituitary Disease
Sherlock, M., Ayuk, J., Tomlinson, J. W., Toogood, A. A., Aragon-Alonso, A., Sheppard, M. C., Bates, A. S., & Stewart, P. M. (2010) · Endocrine Reviews · doi:10.1210/er.2009-0033 · Cited by 392
Neuroendocrine dysfunction in the acute phase of traumatic brain injury
Agha, A., Rogers, B., Mylotte, D., Taleb, F., Tormey, W., Phillips, J., & Thompson, C. J. (2004) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2004.02023.x · Cited by 313
Metadata
- Authors
- Merola, B., Cittadini, A., Colao, A., Longobardi, S., Fazio, S., Sabatini, D., Saccá, L., & Lombardi, G.
- Affiliations
- Federico II University Hospital (IT)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1993-12
- Volume
- 77
- Issue
- 6
- Pages
- 1658-1661
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2029599650
- Cited by
- 253
- References
- 14
- Citations by year
- 2026: 1 · 2023: 1 · 2022: 4 · 2021: 3 · 2019: 5 · 2017: 3 · 2016: 7 · 2015: 5 · 2014: 2 · 2013: 4 · 2012: 7
- FWCI
- 5.80
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Function and Risk Factors
- Keywords
- growth hormone deficiency, cardiac structural abnormalities, left ventricular hypertrophy, left ventricular mass index, left ventricular ejection fraction, fractional shortening, interventricular septum thickness, left ventricular wall thickness, cardiac function, adult patients
- MeSH terms
- Adult, Echocardiography, Female, Heart, Humans, Male, Myocardium, Growth Hormone, Ventricular Function, Left
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency. https://app.cochat.ai/papers/10.1210/jcem.77.6.8263155
- The paper
- Merola, B., Cittadini, A., Colao, A., Longobardi, S., Fazio, S., Sabatini, D., Saccá, L., & Lombardi, G. (1993). Cardiac structural and functional abnormalities in adult patients with growth hormone deficiency. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.77.6.8263155
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
