CoChat
Sign Up
Cited by 177Hypothalamic control of reproductive hormonesOvarian function and disordersRegulation of Appetite and Obesity

The DOI matches its Crossref record; 39 of the 39 references it cites were found in a registry or an index.

Dietary restriction reduces luteinizing hormone (LH) pulse frequency during waking hours and increases LH pulse amplitude during sleep in young menstruating women

Loucks, A. B.·1994·Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.78.4.910
Open this paper in CoChat — free account

Abstract

To determine the effect of dietary energy restriction on gonadotropins, we assayed LH and FSH in samples drawn at 10- and 60-min intervals, respectively, over 24 h from seven young women (mean +/- SE gynecological age, 7.7 +/- 1.2 yr) on day 9, 10, or 11 of two menstrual cycles. Cortisol was measured in samples collected at 30-min intervals. During the 4 previous days and the day of sampling, dietary energy intake was set at either 45 or 10 Cal/kg lean body mass.day in random order. Beginning 2 days before treatment, blood was sampled daily at 0800 h and assayed for T3, insulin-like growth factor-I, and insulin. Estradiol was measured in samples collected daily and at 6-h intervals on the day of frequent sampling. By the day of frequent sampling, dietary restriction had reduced T3 20% (P < 0.01), insulin-like growth factor-I 58% (P < 0.001), and insulin 54% (P < 0.001). Twenty-four-hour transverse means for LH (P = 0.3), FSH (P = 0.2), estradiol (P = 0.3), and cortisol (P = 0.13) were unaffected, but LH pulse frequency was reduced 23% (P < 0.01), especially during waking hours, whereas LH pulse amplitude was increased 40% (P = 0.05), especially during sleep. These results support the hypothesis that LH pulsatility depends upon energy availability in women, as it does in other mammalian species.

Overview

Integrity signals

Registry

Crossref · 10.1210/jc.78.4.910

Cites

39 of 39 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Citations

Cites

Flagged first, then by citations

Show all 39 references

Cited by

Sorted by citations

Items 101–177 of 177

Related

See all

Metadata

Authors
Loucks, A. B.
Affiliations
Ohio University (US)
Venue
Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1994-04-01
Volume
78
Issue
4
Pages
910-915
ISSN
0021-972X (ISSN-L)
DOI
10.1210/jc.78.4.910
OpenAlex
W1970379934
Cited by
174
References
39
Citations by year
2026: 3 · 2025: 3 · 2024: 11 · 2023: 8 · 2022: 4 · 2021: 5 · 2020: 5 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 7 · 2015: 2 · 2014: 3 · 2013: 4 · 2012: 3
FWCI
7.47
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institutes of Health (1r55hd029547-01)
  • National Center for Research Resources (MO1 RR 00034, M01RR000034)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (1R55-HD-29547-01)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
Keywords
hypocaloric diet, luteinizing hormone, LH pulsatility, LH pulse frequency, LH pulse amplitude, gonadotropins, follicle-stimulating hormone, estradiol, cortisol, thyroid-stimulating hormone, insulin-like growth factor I, insulin, energy availability, sleep, menstrual cycle, young women
MeSH terms
Adult, Circadian Rhythm, Estradiol, Female, Food Deprivation, Food, Formulated, Follicle Stimulating Hormone, Humans, Hydrocortisone, Insulin, Insulin-Like Growth Factor I, Luteinizing Hormone, Menstruation, Sleep, Triiodothyronine

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review