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Cited by 337Hypothalamic control of reproductive hormonesPituitary Gland Disorders and TreatmentsAdrenal Hormones and Disorders

Neuroendocrine Aberrations in Women With Functional Hypothalamic Amenorrhea*

BERGA, S. L., MORTOLA, J. F., GIRTON, L., SUH, B., LAUGHLIN, G., PHAM, P., YEN, S. S. C.·1989·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-68-2-301
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Abstract

To further elucidate the neuroendocrine regulation of anterior pituitary function in women with functional hypothalamic amenorrhea (FHA), we measured serum LH, FSH, cortisol, GH, PRL, TSH concentrations simultaneously at frequent intervals for 24 h in 10 women with FHA and in 10 normal women in the early follicular phase (NC). Using the same data, we separately analyzed the cortisol-PRL responses to meals in these women. In addition, the pituitary responses to the simultaneous administration of GnRH, CRH, GHRH, and TRH were assessed in 6 FHA and 6 normal women. The 24-h secretory pattern of each hormone except TSH was altered in the women with FHA. Compared to normal women, the women with FHA had a 53% reduction in LH pulse frequency (P less than 0.0001) and an increase in the mean LH interpulse interval (P less than 0.01); LH pulse amplitude was similar. The 24-h integrated LH and FSH concentrations were reduced 30% (P = 0.01) and 19% (P less than 0.05), respectively. The mean cortisol pulse frequency, amplitude, interpulse interval, and duration were similar in the two groups, but integrated 24-h cortisol secretion was 17% higher in the women with FHA (P less than 0.05). This increase was greatest from 0800-1600 h, but also was present from 2400-0800 h. Cortisol levels were similar in the two groups from 1600-2400 h, resulting in an amplified circadian excursion. In contrast, the 24-h serum PRL levels were markedly lower at all times (P less than 0.0001), the sleep-associat…

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Crossref · 10.1210/jcem-68-2-301

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Authors
BERGA, S. L., MORTOLA, J. F., GIRTON, L., SUH, B., LAUGHLIN, G., PHAM, P., & YEN, S. S. C.
Affiliations
University of California San Diego (US)
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1989-02
Volume
68
Issue
2
Pages
301-308
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-68-2-301
OpenAlex
W1988947995
Cited by
337
References
3
Citations by year
2026: 7 · 2025: 10 · 2024: 13 · 2023: 6 · 2022: 12 · 2021: 4 · 2020: 16 · 2019: 11 · 2018: 7 · 2017: 9 · 2016: 10 · 2015: 8 · 2014: 9 · 2013: 7 · 2012: 4
FWCI
10.20
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Center for Research Resources (RR00827)
  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (HD12303, HD-21198)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
functional hypothalamic amenorrhea, neuroendocrine regulation, anterior pituitary function, LH pulse frequency, follicle-stimulating hormone, cortisol, growth hormone, prolactin, thyroid-stimulating hormone, T3 and T4, GnRH stimulation, corticotropin-releasing factor, growth hormone-releasing hormone, thyrotropin-releasing hormone, thyroid function
MeSH terms
Adult, Amenorrhea, Corticotropin-Releasing Hormone, Female, Follicle Stimulating Hormone, Humans, Hydrocortisone, Hypothalamus, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Middle Aged, Neuroendocrinology, Pituitary Gland, Anterior, Pituitary Hormones, Anterior, Prolactin, Growth Hormone, Growth Hormone-Releasing Hormone, Thyrotropin, Thyrotropin-Releasing Hormone

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