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Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-I insulin- like growth factor receptor
Abstract
In order to account for the effects of insulin on the polycystic ovary (PCO), despite peripheral insulin resistance in women with polycystic ovary syndrome (PCOS), it has been suggested that insulin may act through the type-I insulin-like growth factor (IGF) receptor and not the insulin receptor. We have tested this hypothesis by investigating the effect of anti-insulin receptor and anti-type-I IGF receptor antibodies on insulin-stimulated steroidogenesis in human granulosa cells in vitro from normal (N) and PCO. Insulin-stimulated estradiol and progesterone production was inhibited by an anti-insulin receptor antibody. In contrast, anti-type-I IGF receptor antibodies had no effect on insulin-stimulated steroidogenesis in granulosa cell cultures from N or PCO. Hence insulin acts via its own receptor in human granulosa cells from both N and PCO.
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Citations
Cited by
Diamanti-Kandarakis, E., & Dunaif, A. (2012) · Endocrine Reviews · doi:10.1210/er.2011-1034 · Cited by 1,947
Rosenfield, R. L., & Ehrmann, D. A. (2016) · Endocrine Reviews · doi:10.1210/er.2015-1104 · Cited by 1,603
Nestler, J. E., Jakubowicz, D. J., Falcon de Vargas, A., Brik, C., Quintero, N., & Medina, F. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.6.4886 · Cited by 617
Abbott, D. H., Barnett, D. K., Bruns, C. M., & Dumesic, D. A. (2005) · Human Reproduction Update · doi:10.1093/humupd/dmi013 · Cited by 555
Ibáñez, L., Oberfield, S. E., Witchel, S., Auchus, R. J., Chang, R. J., Codner, E., Dabadghao, P., Darendeliler, F., Elbarbary, N. S., Gambineri, A., et al. (2017) · Hormone Research in Paediatrics · doi:10.1159/000479371 · Cited by 463
Metadata
- Authors
- Willis, D.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1995-12-01
- Volume
- 80
- Issue
- 12
- Pages
- 3788-3790
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W2001301186
- Cited by
- 210
- References
- 0
- FWCI
- 6.84
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-I insulin- like growth factor receptor. https://app.cochat.ai/papers/10.1210/jc.80.12.3788
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- Willis, D. (1995). Insulin action in human granulosa cells from normal and polycystic ovaries is mediated by the insulin receptor and not the type-I insulin- like growth factor receptor. Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jc.80.12.3788
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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