The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.
The effect of hypopituitarism on life expectancy.
Abstract
One hundred and seventy-two patients with partial or complete hypopituitarism diagnosed between 1967 and 1994 were studied retrospectively. Those with acromegaly or Cushing's disease were excluded. One hundred and two patients were male (median age at, diagnosis, 53 yr; range, 12-78 yr) and 70 female (median age at diagnosis, 51 yr; range, 1-74 yr). In 131 patients the cause of hypopituitarism was a pituitary tumor or the effects of its treatment, as the majority underwent surgery and/or radiotherapy. In 22, the cause was an extrapituitary tumor, 14 were termed idiopathic, 2 developed hypopituitarism as a result of basal sarcoid, 2 were due to trauma, and 1 was the result of Sheehan's syndrome. The patients were treated with standard replacement therapy. Mortality due to all causes was higher than expected in an age- and sex-matched control population (ratio of observed/expected deaths, 1.73; 95% confidence interval, 1.28-2.28; P < 0.01). Females tended to have a worse prognosis (ratio of observed/expected deaths, 2.29; 95% confidence interval, 1.37-3.58; P < 0.01) than their male counterparts (ratio of observed/expected deaths, 1.50; 95% confidence interval, 1.02-2.13; P < 0.01). There was a small but nonsignificant increase in the number of deaths due to vascular disease (ratio of observed/expected deaths, 1.35; 95% confidence interval, 0.84-2.07; P = 0.11). The only significant independent predictive factors for survival were age at diagnosis and hypogonadism. The majority…
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Premature mortality due to cardiovascular disease in hypopituitarism
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Bates, A. S., HOFF, W. V., JONES, J. M., & CLAYTON, R. N. (1993) · QJM · doi:10.1093/oxfordjournals.qjmed.a068816 · Cited by 470
Self-citationHypopituitarism Following External Radiotherapy for Pituitary Tumours in Adults
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The growth hormone deficiency syndrome in adults
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“More recently, an increasing amount of evidence has emerged regarding the metabolic and subjective benefits of GH replacement in adults (1).”
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Molitch, M. E., Clemmons, D. R., Malozowski, S., Merriam, G. R., & Vance, M. L. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2011-0179 · Cited by 1,047
Association between premature mortality and hypopituitarism
Tomlinson, J., Holden, N., Hills, R., Wheatley, K., Clayton, R., Bates, A., Sheppard, M., & Stewart, P. (2001) · The Lancet · doi:10.1016/s0140-6736(00)04006-x · Cited by 1,006
Self-citationHormonal Replacement in Hypopituitarism in Adults: An Endocrine Society Clinical Practice Guideline
Fleseriu, M., Hashim, I. A., Karavitaki, N., Melmed, S., Murad, M. H., Salvatori, R., & Samuels, M. H. (2016) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2016-2118 · Cited by 945
Arlt, W., & Allolio, B. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13492-7 · Cited by 819
Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review
Carroll, P. V., Christ the members of Growth Hormon, E. R., Bengtsson, B. Å., Carlsson, L., Christiansen, J. S., Clemmons, D., Hintz, R., Ho, K., Laron, Z., Sizonenko, P., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.2.4594 · Cited by 822
Metadata
- Authors
- Bates, A. S., Van't Hoff, W., Jones, P. J., & Clayton, R. N.
- ORCID
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1996-03
- Volume
- 81
- Issue
- 3
- Pages
- 1169-1172
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2064390644
- Cited by
- 475
- References
- 13
- Citations by year
- 2025: 3 · 2024: 7 · 2023: 9 · 2022: 4 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 12 · 2016: 13 · 2015: 15 · 2014: 19 · 2013: 26 · 2012: 21
- FWCI
- 11.78
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- hypopituitarism, life expectancy, mortality, hypogonadism, hormone replacement therapy, pituitary tumors, vascular disease, sex differences in prognosis, age at diagnosis, prognostic factors, Sheehan's syndrome, sarcoidosis, radiotherapy complications, diabetes insipidus, growth hormone deficiency, ACTH deficiency
- MeSH terms
- Adolescent, Adult, Aged, Cause of Death, Child, Child, Preschool, Female, Humans, Hypopituitarism, Infant, Longevity, Male, Middle Aged, Vascular Diseases
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- Bates, A. S., Van't Hoff, W., Jones, P. J., & Clayton, R. N. (1996). The effect of hypopituitarism on life expectancy. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem.81.3.8772595
