CoChat
Sign Up
Cited by 475Pituitary Gland Disorders and TreatmentsGrowth Hormone and Insulin-like Growth FactorsAdrenal Hormones and Disorders

The DOI matches its Crossref record; 13 of the 13 references it cites were found in a registry or an index.

The effect of hypopituitarism on life expectancy.

Bates, A S, Van't Hoff, W, Jones, P J, Clayton, R N·1996·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.81.3.8772595
Open this paper in CoChat — free account

Abstract

One hundred and seventy-two patients with partial or complete hypopituitarism diagnosed between 1967 and 1994 were studied retrospectively. Those with acromegaly or Cushing's disease were excluded. One hundred and two patients were male (median age at, diagnosis, 53 yr; range, 12-78 yr) and 70 female (median age at diagnosis, 51 yr; range, 1-74 yr). In 131 patients the cause of hypopituitarism was a pituitary tumor or the effects of its treatment, as the majority underwent surgery and/or radiotherapy. In 22, the cause was an extrapituitary tumor, 14 were termed idiopathic, 2 developed hypopituitarism as a result of basal sarcoid, 2 were due to trauma, and 1 was the result of Sheehan's syndrome. The patients were treated with standard replacement therapy. Mortality due to all causes was higher than expected in an age- and sex-matched control population (ratio of observed/expected deaths, 1.73; 95% confidence interval, 1.28-2.28; P < 0.01). Females tended to have a worse prognosis (ratio of observed/expected deaths, 2.29; 95% confidence interval, 1.37-3.58; P < 0.01) than their male counterparts (ratio of observed/expected deaths, 1.50; 95% confidence interval, 1.02-2.13; P < 0.01). There was a small but nonsignificant increase in the number of deaths due to vascular disease (ratio of observed/expected deaths, 1.35; 95% confidence interval, 0.84-2.07; P = 0.11). The only significant independent predictive factors for survival were age at diagnosis and hypogonadism. The majority…

Overview

Integrity signals

Registry

Crossref · 10.1210/jcem.81.3.8772595

Cites

13 of 13 references verified0 citation errors · 0 not checkable

Statistics

Recomputing p-values needs the paper’s full text.

Verification

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Citations

Cites

Show all 13 references

Cited by

Sorted by citations

Related

See all

Metadata

Authors
Bates, A. S., Van't Hoff, W., Jones, P. J., & Clayton, R. N.
ORCID
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1996-03
Volume
81
Issue
3
Pages
1169-1172
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.81.3.8772595
OpenAlex
W2064390644
Cited by
475
References
13
Citations by year
2025: 3 · 2024: 7 · 2023: 9 · 2022: 4 · 2021: 7 · 2020: 10 · 2019: 9 · 2018: 9 · 2017: 12 · 2016: 13 · 2015: 15 · 2014: 19 · 2013: 26 · 2012: 21
FWCI
11.78
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Keywords
hypopituitarism, life expectancy, mortality, hypogonadism, hormone replacement therapy, pituitary tumors, vascular disease, sex differences in prognosis, age at diagnosis, prognostic factors, Sheehan's syndrome, sarcoidosis, radiotherapy complications, diabetes insipidus, growth hormone deficiency, ACTH deficiency
MeSH terms
Adolescent, Adult, Aged, Cause of Death, Child, Child, Preschool, Female, Humans, Hypopituitarism, Infant, Longevity, Male, Middle Aged, Vascular Diseases

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review