A Paradigm of Experimentally Induced Mild Hyperthyroidism: Effects on Nitrogen Balance, Body Composition, and Energy Expenditure in Healthy Young Men
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Short-term studies of supraphysiologic thyroid hormone doses uniformly showed increased resting and 24-hour energy expenditure, but were too brief to document changes in body composition.
“These studies uniformly showed increased resting and 24-hour energy expenditure, but were too brief to document changes in body composition.”
From Effects of levothyroxine replacement or suppressive therapy on energy expenditure and body composition (2016) · cites this paper as [6]
Most prior studies of supraphysiologic thyroid hormone doses utilized high doses of levotriiodothyronine (LT3), not minimally suppressive doses of LT4.
“In addition, most utilized high doses of levotriiodothyronine (LT3), not minimally suppressive doses of LT4.”
From Effects of levothyroxine replacement or suppressive therapy on energy expenditure and body composition (2016) · cites this paper as [6]
Past studies have reported increased resting or 24-hour energy expenditure and whole body oxygen consumption with exogenous administration of pharmacologic doses of LT4 or LT3 to healthy humans due to increased expression of uncoupling proteins and decreased mitochondrial efficiency.
“Past studies have reported increased resting or 24-hour energy expenditure and whole body oxygen consumption with exogenous administration of pharmacologic doses of LT4 or LT3 to healthy humans (3-7) due to increased expression of uncoupling proteins and decreased mitochondrial efficiency (3,4,7).”
From Effects of levothyroxine replacement or suppressive therapy on energy expenditure and body composition (2016) · cites this paper as [6]
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- Authors
- Lovejoy, J. C.
- Corresponding author
- Lovejoy, J. C.
- ORCID
- Lovejoy, J. C.
- Venue
- Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1997-03-01
- Volume
- 82
- Issue
- 3
- Pages
- 765-770
- ISSN
- 0021-972X (ISSN-L)
- OpenAlex
- W4249402146
- Cited by
- 41
- References
- 0
- Citations by year
- 2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 1
- FWCI
- 2.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- hyperthyroidism, experimental hyperthyroidism, nitrogen balance, body composition, energy expenditure, young men, thyroid hormone effects
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