Cited by 41Thyroid Disorders and TreatmentsRegulation of Appetite and ObesityHormonal and reproductive studies

A Paradigm of Experimentally Induced Mild Hyperthyroidism: Effects on Nitrogen Balance, Body Composition, and Energy Expenditure in Healthy Young Men

Lovejoy, J. C.·1997·Journal of Clinical Endocrinology & Metabolism

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Crossref · 10.1210/jc.82.3.765

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  • Short-term studies of supraphysiologic thyroid hormone doses uniformly showed increased resting and 24-hour energy expenditure, but were too brief to document changes in body composition.

    “These studies uniformly showed increased resting and 24-hour energy expenditure, but were too brief to document changes in body composition.”
  • Most prior studies of supraphysiologic thyroid hormone doses utilized high doses of levotriiodothyronine (LT3), not minimally suppressive doses of LT4.

    “In addition, most utilized high doses of levotriiodothyronine (LT3), not minimally suppressive doses of LT4.”
  • Past studies have reported increased resting or 24-hour energy expenditure and whole body oxygen consumption with exogenous administration of pharmacologic doses of LT4 or LT3 to healthy humans due to increased expression of uncoupling proteins and decreased mitochondrial efficiency.

    “Past studies have reported increased resting or 24-hour energy expenditure and whole body oxygen consumption with exogenous administration of pharmacologic doses of LT4 or LT3 to healthy humans (3-7) due to increased expression of uncoupling proteins and decreased mitochondrial efficiency (3,4,7).”

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Authors
Lovejoy, J. C.
Corresponding author
Lovejoy, J. C.
Venue
Journal of Clinical Endocrinology & Metabolism
Published
1997-03-01
Volume
82
Issue
3
Pages
765-770
ISSN
0021-972X (ISSN-L)
OpenAlex
W4249402146
Cited by
41
References
0
Citations by year
2024: 1 · 2023: 1 · 2022: 1 · 2021: 3 · 2020: 2 · 2019: 1 · 2018: 1 · 2017: 1 · 2016: 2 · 2015: 3 · 2014: 1 · 2013: 1 · 2012: 1
FWCI
2.14
Type
journal article
Language
en
Open access
closed
Locations
The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Regulation of Appetite and Obesity
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Keywords
hyperthyroidism, experimental hyperthyroidism, nitrogen balance, body composition, energy expenditure, young men, thyroid hormone effects

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