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Cited by 922

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Testosterone Replacement in Older Hypogonadal Men: A 12-Month Randomized Controlled Trial

Sih, R.·1997·Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jc.82.6.1661
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Abstract

A decline in testicular function is recognized as a common occurrence in older men. However data are sparse regarding the effects of hypogonadism on age-associated physical and cognitive declines. This study was undertaken to examine the year-long effects of testosterone administration in this patient population. Fifteen hypogonadal men (mean age 68 +/- 6 yr) were randomly assigned to receive a placebo, and 17 hypogonadal men (mean age 65 +/- 7 yr) were randomly assigned to receive testosterone. Hypogonadism was defined as a bioavailable testosterone <60 ng/dL. The men received injections of placebo or 200 mg testosterone cypionate biweekly for 12 months. The main outcomes measured included grip strength, hemoglobin, prostate-specific antigen, leptin, and memory. Testosterone improved bilateral grip strength (P < 0.05 by ANOVA) and increased hemoglobin (P < 0.001 by ANOVA). The men assigned to testosterone had greater decreases in leptin than those assigned to the control group (mean +/- SEM: -2.0 +/- 0.9 ng/dL vs. 0.8 +/- 0.7 ng/dL; P < 0.02). There were no significant changes in prostate-specific antigen or memory. Three subjects receiving placebo and seven subjects receiving testosterone withdrew from the study. Three of those seven withdrew because of an abnormal elevation in hematocrit. Testosterone supplementation improved strength, increased hemoglobin, and lowered leptin levels in older hypogonadal men. Testosterone may have a role in the treatment of frailty in males with hypogonadism; however, older men receiving testosterone must be carefully monitored because of its potential risks.

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Cites

Research works printed but not linked: 41

  1. 1991, Endocrine factors in geriatric sexuality., Clin Geriatr Med, 7, 85, 10.1016/S0749-0690(18)30567-6 · DOI
  2. Nankin, 1986, Decreased bioavailable testosterone in aging, normal and impotent men., J Clin Endocrinol Metab, 63, 1418, 10.1210/jcem-63-6-1418 · DOI
  3. Bremner, 1983, Loss of circadian rhythmicity in blood testosterone levels with aging in normal men., J Clin Endocrinol Metab, 56, 1278, 10.1210/jcem-56-6-1278 · DOI · Paper page
  4. Vermeulen, 1972, Testosterone secretion and metabolism in male senescence., J Clin Endocrinol Metab, 34, 730, 10.1210/jcem-34-4-730 · DOI · Paper page
  5. Gray, 1991, An examination of research design effects on the association of testosterone and male aging: results of a meta-analysis., J Clin Epidemiol, 44, 671, 10.1016/0895-4356(91)90028-8 · DOI · Paper page
  6. Korenman, 1990, Secondary hypogonadism in older men: its relationship to impotence., J Clin Endocrinol Metab, 71, 963, 10.1210/jcem-71-4-963 · DOI · Paper page
  7. Shimokata, 1989, Studies in the distribution of body fat, I. Effects of age, sex and obesity. J Gerontol Med Sci., 44, M66, 10.1093/geronj/44.2.M66 · DOI · Paper page
  8. Griggs, 1989, 39, 219
  9. Griggs, 1989, 66, 498
  10. Bhasin, 1996, 335, 1
  11. Morley, 1993, Effects of testosterone replacement therapy in old hypogonadal males: a preliminary study., J Am Geriatr Soc, 41, 149, 10.1111/j.1532-5415.1993.tb02049.x · DOI · Paper page
  12. Frontera, 1988, Strength conditioning in older men: skeletal muscle hypertrophy and improved function., J Appl Physiol, 64, 1038, 10.1152/jappl.1988.64.3.1038 · DOI · Paper page
  13. Fleg, 1988, Role of muscle loss in the age-associated reduction in VO2 max., J Appl Physiol, 65, 1147, 10.1152/jappl.1988.65.3.1147 · DOI · Paper page
  14. 1990, The scientific basis of exercise prescribing for the very old., J Am Geriatr Soc, 38, 62, 10.1111/j.1532-5415.1990.tb01600.x · DOI
  15. Borkowski, 1967, Word fluency and brain damage., Neuropsychologia, 5, 135, 10.1016/0028-3932(67)90015-2 · DOI · Paper page
  16. Kaiser, 1988, Impotence and aging: clinical and hormonal factors., J Am Geriatr Soc, 36, 511, 10.1111/j.1532-5415.1988.tb04021.x · DOI
  17. Negoro, 1988, Utility of serum fructosamine as a measure of glycemia in young and old diabetic and non-diabetic subjects., Am J Med, 85, 360, 10.1016/0002-9343(88)90587-6 · DOI
  18. Carlson, 1964, Electromyographic study of aging in skeletal muscle., Am J Phys Med, 43, 141, 10.1097/00002060-196408000-00001 · DOI
  19. Kochakian, 1956, The effects of castration on the weight and composition of the muscles of the guinea pig., Endocrinology, 58, 315, 10.1210/endo-58-3-315 · DOI
  20. Ensrud, 1994, Correlates of impaired function in older women., J Am Geriatr Soc, 42, 481, 10.1111/j.1532-5415.1994.tb04968.x · DOI · Paper page
  21. Sunderland, 1989, Arm function after stroke. An evaluation of grip strength as a measure of recovery and a prognostic indicator., J Neurol Neurosurg Psychiatry, 52, 1267, 10.1136/jnnp.52.11.1267 · DOI · Paper page
  22. Nikolaus, 1995, The timed test of money counting: a short physical performance test for manual dexterity and cognitivie capacity., Age Ageing, 24, 257, 10.1093/ageing/24.3.257 · DOI
  23. Hughes, 1995, Predictors of hand function in older persons: a two year longitudinal analysis., J Am Geriatr Soc, 43, 122, 10.1111/j.1532-5415.1995.tb06376.x · DOI
  24. Spiegel, 1987, What are we measuring? An examination of walk time and grip strength., J Rheumatol, 14, 80
  25. Laukkanen, 1994, Factors related to carrying out everyday activities among elderly people aged 80., Aging, 6, 433
  26. Minor, 1995, Physical fitness and work capacity in women with rheumatoid arthritis., Arthritis Care Res, 8, 146, 10.1002/art.1790080306 · DOI
  27. Weber, 1991, Effects of reversible androgen deprivation on hemoglobin and serum immunoreactive erythropoietin in men., Am J Hematol, 36, 190, 10.1002/ajh.2830360306 · DOI
  28. Janne, 1975, DNA-dependent RNA polymerase I, and II from kidney. Effect of polyamines on the in vitro transcription of DNA and chromatin., Biochemistry, 14, 3589, 10.1021/bi00687a012 · DOI
  29. Wade, 1979, Theoretical review. Gonadal effects on food intake and adiposity: metabolic hypothesis., Physiol Behav, 22, 583, 10.1016/0031-9384(79)90028-3 · DOI · Paper page
  30. 1982, Brief report. Dose dependent effects of testosterone on feeding and body weight in male rats., Behav Neural Biol, 34, 445, 10.1016/S0163-1047(82)91888-X · DOI
  31. Kochakian, 1958, Effect of testosterone propionate on the appetite, body weight and composition of the normal rat., Endocrinology, 63, 737, 10.1210/endo-63-6-737 · DOI
  32. Leshner, 1973, The effects of gonadectomy on the sex differences in dietary self selection patterns and carcass compositions of rats., Physiol Behav, 11, 671, 10.1016/0031-9384(73)90253-9 · DOI
  33. Reid, 1996, Testosterone therapy in glucocorticoid treated men., Arch Intern Med, 156, 1173, 10.1001/archinte.1996.00440100065008 · DOI · Paper page
  34. Halaas, 1995, Weight reducing effects of the plasma protein encoded by the obese gene., Science, 269, 543, 10.1126/science.7624777 · DOI · Paper page
  35. Considine, 1996, Studies of circulating leptin by radioimmunoassay in humans with and without obesity., N Engl J Med, 334, 292, 10.1056/NEJM199602013340503 · DOI · Paper page
  36. Christiansen, 1987, Sex hormones and cognitive functioning in men., Neuropsychobiology, 18, 27, 10.1159/000118389 · DOI · Paper page
  37. Flood, 1995, Age related decrease of plasma testosterone in SAM-P8 mice: replacement improves age related impairment of learning and memory., Physiol Behav, 57, 669, 10.1016/0031-9384(94)00318-1 · DOI
  38. Janowsky, 1994, Testosterone influences spatial cognition in older men., Behav Neurosci, 108, 625, 10.1037/0735-7044.108.2.325 · DOI · Paper page
  39. Finkelstein, 1989, Increases in bone density during treatment of men with idioipathic hypogonadotropic hypogonadism., J Clin Endocrinol Metab, 69, 776, 10.1210/jcem-69-4-776 · DOI · Paper page
  40. Somjen, 1989, Modulation by vitamin D status of the responsiveness of rat bone to gonadal steroids., Endocrinology, 125, 1870, 10.1210/endo-125-4-1870 · DOI
  41. Francis, 1986, Osteoporosis in hypogonadal men: role of decreased plasma 1,25 dihydroxyvitamin D, calcium malabsorption and low bone formation., Bone, 7, 261, 10.1016/8756-3282(86)90205-X · DOI

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Metadata

Authors
Sih, R.
Venue
Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1997-06-01
Volume
82
Issue
6
Pages
1661-1667
ISSN
0021-972X (ISSN-L)
DOI
10.1210/jc.82.6.1661
OpenAlex
W1985592735
Cited by
922
References
6
FWCI
30.96
Type
journal article
Language
en
Open access
closed

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