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Testosterone Secretion and Metabolism in Male Senescence
Abstract
The influence of aging on plasma testosterone levels and testosterone metabolism in males was studied. It was observed that plasma testosterone levels and the apparent free plasma testosterone concentration (AFTC) remain within the same range from adolescence until the age of 50 yr, but that from the 6th decade on, the mean plasma levels decrease rather rapidly, with however a wide range of individual values. As the metabolic clearance rate (MCR) decreases in male senescence, the net result is an important decrease in the testosterone blood production rate. Within the group of subjects studied, a statistically significant correlation between the free testosterone fraction and the MCR was found. It was observed that testosterone metabolism in male senescence is characterized by a relative decrease of the formation of androstanediols, with a relative increase of 5β over 5α metabolites;moreover a statistically significant correlation between the formation of 5α-androstane-3α,17β-diol and the free testosterone fraction was found. As the latter metabolite is largely formed in peripheral target tissues, this suggests that testosterone metabolism by target tissues becomes more important with increasing free T fraction and indirectly, that only free testosterone can be taken up by target tissues.
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Citations
Cited by
Longitudinal Effects of Aging on Serum Total and Free Testosterone Levels in Healthy Men
Harman, S. M., Metter, E. J., Tobin, J. D., Pearson, J., & Blackman, M. R. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.2.7219 · Cited by 2,760
ANDERSON, D. C. (1974) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1974.tb03298.x · Cited by 1,127
The Decline of Androgen Levels in Elderly Men and Its Clinical and Therapeutic Implications
Kaufman, J. M., & Vermeulen, A. (2005) · Endocrine Reviews · doi:10.1210/er.2004-0013 · Cited by 1,079
Self-citationLoss of Circadian Rhythmicity in Blood Testosterone Levels with Aging in Normal Men*
Bremner, W. J., Vitiello, M. V., & Prinz, P. N. (1983) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-56-6-1278 · Cited by 785
Vanderschueren, D., Vandenput, L., Boonen, S., Lindberg, M. K., Bouillon, R., & Ohlsson, C. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0003 · Cited by 717
Metadata
- Authors
- VERMEULEN, A., RUBENS, R., & VERDONCK, L.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1972-04
- Volume
- 34
- Issue
- 4
- Pages
- 730-735
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2076739340
- Cited by
- 532
- References
- 0
- FWCI
- 17.67
- Type
- journal article
- Language
- en
- Open access
- closed
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- VERMEULEN, A., RUBENS, R., & VERDONCK, L. (1972). Testosterone Secretion and Metabolism in Male Senescence. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-34-4-730
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
