Biological Actions of Androgens

MOORADIAN, A. D.; MORLEY, J. E.; KORENMAN, S. G.

doi:10.1210/edrv-8-1-1

Cited by 1,080Hormonal and reproductive studiesEstrogen and related hormone effectsProstate Cancer Treatment and Research

Biological Actions of Androgens

MOORADIAN, A. D., MORLEY, J. E., KORENMAN, S. G.·1987·Endocrine Reviews

DOI 10.1210/edrv-8-1-1

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Abstract

Though unnecessary for life itself, androgens are essential for the propagation of the species and for establishment and maintenance of the quality of life of males through their support of sexual behavior and function, muscle strength, and sense of well-being. In carrying out its many functions, T acts both as hormone and prohormone. It is an outstanding example of the diverse evolutionary utilization of a primitive informational molecule both among and within species. Not only does T act through the androgen receptor both unchanged and via 5 alpha-reduction, but it acts in tissues with a high aromatase level as an estrogen via the estrogen receptor. Furthermore, DHT, binding to the estrogen receptor, can act as an inhibitor of estrogen action. The products of androgen metabolism may also play active regulatory roles in hematopoiesis and in the regulation of certain hepatic enzymes. Table 3 summarizes the actions of secreted T in males indicating the probable effector hormone. While gross hypogonadism is uncommon, mild androgen insufficiency may be much more frequent, especially in older men, and in those receiving treatment for chronic medical conditions. It is quite possible that such individuals would benefit from appropriate androgen therapy were it available, but the current forms of replacement therapy are not very satisfactory. Better approaches are required. With the exception of a small number of secreted proteins, the products of transcription induced by androgens are not, as yet, known. When the androgen receptor gene is cloned it will be possible to identify androgen-regulated genes and their products. It will then be possible to design agents selectively producing specific desired androgenic effects.

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Testosterone is a highly studied androgen that is associated with an increase in muscle mass.
“Testosterone is a highly studied androgen that is associated with an increase in muscle mass (66, 83).”
From Sex-Based Differences in Skeletal Muscle Kinetics and Fiber-Type Composition (2015) · cites this paper as [66]

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Glass, B. (1960) · Bulletin of the Atomic Scientists · doi:10.1080/00963402.1960.11454102 · Cited by 806 · see citing works
Gonadal effects on food intake and adiposity: a metabolic hypothesis.
Wade, G., & Gray, J. (1979) · Physiology and Behavior · doi:10.1016/0031-9384(79)90028-3 · Cited by 458 · see citing works
Prostatein. A major secretory protein of the rat ventral prostate.
Lea, O. A., Petrusz, P., & French, F. S. (1979) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)50537-8 · Cited by 140 · see citing works

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Self-citation
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Ferreira, I. M., VERRESCHI, I. T. D. N., Nery, L. E., Goldstein, R. S., Zamel, N., Brooks, D., & Jardim, J. R. (1998) · CHEST Journal · doi:10.1378/chest.114.1.19 · Cited by 241 · see citing works
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Turner, R. T., Wakley, G. K., & Hannon, K. S. (1990) · Journal of Orthopaedic Research · doi:10.1002/jor.1100080418 · Cited by 238 · see citing works
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Wersinger, S. R., Sannen, K., Villalba, C., Lubahn, D. B., Rissman, E. F., & Vries, G. J. D. (1997) · Hormones and Behavior · doi:10.1006/hbeh.1997.1419 · Cited by 240 · see citing works
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HORMONAL REGULATION OF HUMAN MUSCLE PROTEIN METABOLISM
Rooyackers, O., & Nair, K. S. (1997) · Annual Review of Nutrition · doi:10.1146/annurev.nutr.17.1.457 · Cited by 225 · see citing works
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Mariotti, A. J. (1994) · Critical Reviews in Oral Biology & Medicine · doi:10.1177/10454411940050010201 · Cited by 222 · see citing works
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Anderson, L. J., Liu, H. M., & Garcia, J. M. (2017) · Advances in experimental medicine and biology · doi:10.1007/978-3-319-70178-3_9 · Cited by 222 · see citing works
Dietary soy-phytoestrogens decrease testosterone levels and prostate weight without altering LH, prostate 5alpha-reductase or testicular steroidogenic acute regulatory peptide levels in adult male Sprague-Dawley rats
Weber, K. S., Setchell, K. D. R., Stocco, D. M., & Lephart, E. D. (2001) · Journal of Endocrinology · doi:10.1677/joe.0.1700591 · Cited by 220 · see citing works
Expanding the therapeutic use of androgens via selective androgen receptor modulators (SARMs)
Gao, W., & Dalton, J. T. (2007) · Drug Discovery Today · doi:10.1016/j.drudis.2007.01.003 · Cited by 216 · see citing works
Exogenous androgens influence body composition and regional body fat distribution in obese postmenopausal women--a clinical research center study.
Lovejoy, J. C., Bray, G. A., Bourgeois, M., Macchiavelli, R. E., Rood, J. C., Greeson, C., & Partington, C. (1996) · Journal of Clinical Endocrinology and Metabolism · doi:10.1210/jcem.81.6.8964851 · Cited by 235 · see citing works
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Khetawat, G., Faraday, N. R., Nealen, M. L., Vijayan, K. V., Bolton, E., Noga, S. J., & Bray, P. F. (2000) · Blood · doi:10.1182/blood.v95.7.2289 · Cited by 212 · see citing works
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Moghetti, P., & Tosi, F. (2021) · Journal of Endocrinological Investigation · doi:10.1007/s40618-020-01351-0 · Cited by 209 · see citing works
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Doesburg, P., Kuil, C. W., Berrevoets, C., Steketee, K., Faber, P. W., Mulder, E., Brinkmann, A. O., & Trapman, J. (1997) · Biochemistry · doi:10.1021/bi961775g · Cited by 209 · see citing works
Cardiovascular Disease Among Transgender Adults Receiving Hormone Therapy
Streed, C. G., Harfouch, O., Marvel, F. A., Blumenthal, R. S., Martin, S. S., & Mukherjee, M. (2017) · Annals of Internal Medicine · doi:10.7326/m17-0577 · Cited by 207 · see citing works
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Xu, X., Pergola, G. D., & Björntorp, P. A. (1990) · Endocrinology · doi:10.1210/endo-126-2-1229 · Cited by 202 · see citing works
Testosterone attenuates β-amyloid toxicity in cultured hippocampal neurons
Pike, C. J. (2001) · Brain Research · doi:10.1016/s0006-8993(01)03024-4 · Cited by 200 · see citing works
Late onset of obesity in male androgen receptor-deficient (AR KO) mice
Sato, T., Μatsumoto, T., Yamada, T., Watanabe, T., Kawano, H., & Kato, S. (2003) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(02)02774-2 · Cited by 196 · see citing works
Non-classical actions of testosterone: an update
Rahman, F., & Christian, H. (2007) · Trends in Endocrinology and Metabolism · doi:10.1016/j.tem.2007.09.004 · Cited by 195 · see citing works
Differential effects of gonadal function on bone histomorphometry in male and female rats
Turner, R. T., Hannon, K. S., Demers, L. M., Buchanan, J. R., & Bell, N. H. (1989) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650040415 · Cited by 193 · see citing works
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Sinha‐Hikim, I., Arver, S., Beall, G. N., Shen, R., Guerrero, M., Sattler, F. R., Shikuma, C., Nelson, J. C., Landgren, B.-M., Mazer, N. A., et al. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.4.4718 · Cited by 192 · see citing works
Androgen treatment prevents loss of cancellous bone in the orchidectomized rat
Wakley, G. K., Schutte, H. D., Hannon, K. S., & Turner, R. T. (1991) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.5650060403 · Cited by 190 · see citing works
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Lu, S., Liu, M., Epner, D. E., Tsai, S. Y., & Tsai, M. (1999) · Molecular Endocrinology · doi:10.1210/mend.13.3.0254 · Cited by 185 · see citing works
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Androgen Induction of Cyclin-Dependent Kinase Inhibitor p21 Gene: Role of Androgen Receptor and Transcription Factor Sp1 Complex
Lu, S., Jenster, G. W., & Epner, D. E. (2000) · Molecular Endocrinology · doi:10.1210/mend.14.5.0461 · Cited by 175 · see citing works
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Henttu, P. M. A., Liao, S. S., & Vihko, P. (1992) · Endocrinology · doi:10.1210/endo.130.2.1370795 · Cited by 173 · see citing works
Physiology of Testicular Function
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Perry, H. M., Miller, D. K., Patrick, P., & Morley, J. E. (2000) · Metabolism · doi:10.1053/meta.2000.7710 · Cited by 168 · see citing works
Self-citation
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Bhasin, S., Storer, T. W., Asbel-Sethi, N., Kilbourne, A. M., Hays, R. D., Sinha‐Hikim, I., Shen, R., Arver, S., & Beall, G. N. (1998) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.83.9.5079 · Cited by 165 · see citing works
The Direct Pituitary Effect of Testosterone to Inhibit Gonadotropin Secretion in Men Is Partially Mediated by Aromatization to Estradiol
Bagatell, C. J., Dahl, K. D., & Bremner, W. J. (1994) · Journal of Andrology · doi:10.1002/j.1939-4640.1994.tb01674.x · Cited by 164 · see citing works
Elevated Dehydroepiandrosterone Sulfate Levels as the Reproductive Phenotype in the Brothers of Women with Polycystic Ovary Syndrome
Legro, R. S., Kunselman, A. R., Demers, L., Wang, S. C., Bentley–Lewis, R., & Dunaif, A. E. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8387 · Cited by 161 · see citing works
Emerging Issues in Androgen Replacement Therapy1
Bhasin, S., & Bremner, W. J. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.1.3640 · Cited by 160 · see citing works
The association of testosterone, sleep, and sexual function in men and women
Andersen, M. L., Alvarenga, T. A., Mazaro‐Costa, R., Hachul, H., & Tufik, S. (2011) · Brain Research · doi:10.1016/j.brainres.2011.07.060 · Cited by 156 · see citing works
Elevated Testosterone Induces Apoptosis in Neuronal Cells
Estrada, M., Varshney, A., & Ehrlich, B. E. (2006) · Journal of Biological Chemistry · doi:10.1074/jbc.m603193200 · Cited by 156 · see citing works
Pharmacodynamics of Selective Androgen Receptor Modulators
Yin, D., Gao, W., Kearbey, J. D., Xu, H., Chung, K., He, Y., Marhefka, C. A., Veverka, K. A., Miller, D. D., & Dalton, J. T. (2003) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.102.040840 · Cited by 156 · see citing works
Neutropenia with impaired host defense against microbial infection in mice lacking androgen receptor
Chuang, K., Altuwaijri, S., Li, G., Lai, J., Chu, C., Lai, K., Lin, H., Hsu, J., Keng, P., Wu, M., et al. (2009) · The Journal of Experimental Medicine · doi:10.1084/jem.20082521 · Cited by 152 · see citing works
Androgen Receptor Gene Knockout Male Mice Exhibit Impaired Cardiac Growth and Exacerbation of Angiotensin II-induced Cardiac Fibrosis
Ikeda, Y., Aihara, K., Sato, T., Akaike, M., Yoshizumi, M., Suzaki, Y., Izawa, Y., Fujimura, M., Hashizume, S., Kato, M., et al. (2005) · Journal of Biological Chemistry · doi:10.1074/jbc.m411694200 · Cited by 151 · see citing works
Molecular Mechanisms of Androgen Action
Lindzey, J. K., Kumar, M. V., Grossman, M., Young, C. Y. F., & Tindall, D. J. (1994) · Vitamins and hormones · doi:10.1016/s0083-6729(08)61151-6 · Cited by 146 · see citing works
Localization of androgen receptor expression in human bone marrow
Mantalaris, A., Panoskaltsis, N., Sakai, Y., Bourne, P. A., Chang, C., Messing, E. M., & Wu, J. (2001) · The Journal of Pathology · doi:10.1002/1096-9896(0000)9999:9999 · Cited by 148 · see citing works
Sex Steroids and the Periosteum—Reconsidering the Roles of Androgens and Estrogens in Periosteal Expansion
Vanderschueren, D., Venken, K., Ophoff, J., Bouillon, R., & Boonen, S. (2006) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-1766 · Cited by 145 · see citing works
Testosterone buciclate (20 Aet-1) in hypogonadal men: pharmacokinetics and pharmacodynamics of the new long-acting androgen ester
Behre, H. M., & Nieschlag, E. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.75.5.1430080 · Cited by 145 · see citing works
Hypothalamo-Pituitary Gonadal Axis in Chronic Renal Failure
Handelsman, D. J., & Dong, Q. (1993) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30184-1 · Cited by 144 · see citing works
The Rationale, Efficacy and Safety of Androgen Therapy in Older Men: Future Research and Current Practice Recommendations
Liu, P. Y., Swerdloff, R. S., & Veldhuis, J. D. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2004-0807 · Cited by 143 · see citing works
Lipodystrophy defined by a clinical score in HIV-infected men on highly active antiretroviral therapy: correlation between dyslipidaemia and steroid hormone alterations
Christeff, N., Melchior, J., de Truchis, P., Perronne, C., Nunez, E. A., & Gougeon, M. (1999) · AIDS · doi:10.1097/00002030-199911120-00007 · Cited by 142 · see citing works
Small Molecules for Active Targeting in Cancer
Kue, C. S., Kamkaew, A., Burgess, K., Kiew, L. V., Chung, L. Y., & Lee, H. B. (2016) · Medicinal Research Reviews · doi:10.1002/med.21387 · Cited by 143 · see citing works
Trinucleotide repeats in the human androgen receptor: a molecular basis for disease
Choong, C. S., & Em, W. (1998) · Journal of Molecular Endocrinology · doi:10.1677/jme.0.0210235 · Cited by 143 · see citing works
Two different, overlapping pathways of transcription initiation are active on the TATA-less human androgen receptor promoter. The role of Sp1
Faber, P. W., van Rooij, H. C., Schipper, H. J., Brinkmann, A. O., & Trapman, J. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)98349-3 · Cited by 140 · see citing works

Authors: MOORADIAN, A. D., MORLEY, J. E., & KORENMAN, S. G.
Affiliations: United States Department of Veterans Affairs (US)
Corresponding author: KORENMAN, S. G.
ORCID: MORLEY, J. E.
Venue: Endocrine Reviews
Publisher: The Endocrine Society
Published: 1987-02
Volume: 8
Issue: 1
Pages: 1-28
ISSN: 0163-769X (ISSN-L)
1945-7189
DOI: 10.1210/edrv-8-1-1
OpenAlex: W2027586930
Cited by: 1,080
References: 3
Citations by year: 2026: 10 · 2025: 7 · 2024: 19 · 2023: 27 · 2022: 27 · 2021: 41 · 2020: 41 · 2019: 26 · 2018: 31 · 2017: 35 · 2016: 40 · 2015: 29 · 2014: 29 · 2013: 33 · 2012: 39
FWCI: 16.17
Type: journal article
Language: en
Open access: closed
Locations: Endocrine Reviews (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Estrogen and related hormone effects
Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Prostate Cancer Treatment and Research
Keywords: androgens, testosterone, dihydrotestosterone, androgen receptor, aromatase, estrogen receptor, 5α-reduction, androgen metabolism, hematopoiesis, hepatic enzyme regulation, androgen deficiency, testosterone replacement therapy, androgen-regulated genes, male sexual function, muscle strength
MeSH terms: Androgens, Animals, Brain, Breast, Genitalia, Male, Heart, Hematopoiesis, Humans, Hypothalamo-Hypophyseal System, Immune System, Kidney, Libido, Male, Mammary Glands, Animal, Sexual Behavior, Animal, Sex Characteristics, Testis, Muscle Development

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