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Cited by 111Adrenal Hormones and DisordersStress Responses and CortisolElectrolyte and hormonal disorders

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

High fluid intake increases urine free cortisol excretion in normal subjects.

Mericq, M. Veronica, Cutler, Gordon B.·1998·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem.83.2.4555
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Abstract

To test the hypothesis that increased fluid intake increases the urine free cortisol, we prescribed 5 liters of fluid intake per day or a normal fluid intake according to a randomized cross-over design in six normal volunteers. Each period lasted 5 days, with a 2-day washout period of normal fluid intake between the two periods. Urine free cortisol, 17-hydroxycorticosteroids, and creatinine were measured daily during each study period, and the average value over each 5-day period was calculated for each subject. High fluid intake caused a significant increase in the mean urine free cortisol [126 +/- 33 (SD) vs. 77 +/- 18 micrograms/day, P < 0.005]. The frequency of urine free cortisol results that exceeded the upper normal limit of 95 micrograms/day was also much higher during high fluid intake (23/30 vs. 6/30, P < 0.005). By contrast, urine 17-hydroxycorticosteroids (high fluid vs. normal fluid: 5.3 +/- 1.5 vs. 5.0 +/- 1.7 mg/day, respectively, P = not significant) and urine creatinine (1.51 +/- 0.48 vs. 1.45 +/- 0.37 g/day, P = not significant) did not differ between the two study periods. We conclude that high fluid intake (5 liters/day) increases free cortisol excretion without an increase in urine 17-hydroxycorticosteroids. Thus, mild to moderate increases in urine cortisol excretion may not indicate hypercortisolism in individuals who have a high fluid intake and urine volume.

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Crossref · 10.1210/jcem.83.2.4555

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Metadata

Authors
Mericq, M. V., & Cutler, G. B.
Affiliations
National Institutes of Health (US)
ORCID
Cutler, Gordon B.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1998-02
Volume
83
Issue
2
Pages
682-684
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem.83.2.4555
OpenAlex
W2171909930
Cited by
111
References
16
Citations by year
2026: 2 · 2024: 4 · 2023: 1 · 2022: 3 · 2021: 3 · 2020: 3 · 2019: 6 · 2018: 4 · 2017: 8 · 2016: 6 · 2015: 4 · 2014: 3 · 2013: 4 · 2012: 5
FWCI
3.22
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
  • Health Sciences › Medicine › Nephrology › Electrolyte and hormonal disorders
Keywords
fluid intake, urinary free cortisol, cortisol excretion, 17-hydroxycorticosteroids, urinary creatinine, hypercortisolism, urine output, normal subjects
MeSH terms
Adult, Creatinine, Drinking, Female, Humans, Hydrocortisone, Male, Urine, 17-Hydroxycorticosteroids

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