Cited by 1,181Adipokines, Inflammation, and Metabolic DiseasesAdipose Tissue and MetabolismCardiovascular Disease and Adiposity

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Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin

Yang, Wei-Shiung, Lee, Wei-Jei, Funahashi, Tohru, Tanaka, Sachiyo, Matsuzawa, Yuji, Chao, Chia-Ling, Chen, Chi-Ling, Tai, Tong-Yuan, Chuang, Lee-Ming·2001·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jc.86.8.3815

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Abstract

Adiponectin, an adipose tissue-specific plasma protein, was recently revealed to have anti-inflammatory effects on the cellular components of vascular wall. Its plasma levels were significantly lower in men than in women and lower in human subjects with obesity, type 2 diabetes mellitus, or coronary artery disease. Therefore, it may provide a biological link between obesity and obesity-related disorders such as atherosclerosis, against which it may confer protection. In this study, we observed the changes of plasma adiponectin levels with body weight reduction among 22 obese patients who received gastric partition surgery. A 46% increase of mean plasma adiponectin level was accompanied by a 21% reduction in mean body mass index. The change in plasma adiponectin levels was significantly correlated with the changes in body mass index (r = −0.5, P = 0.01), waist (r = −0.4, P = 0.04) and hip (r =− 0.6, P = 0.0007) circumferences, and steady state plasma glucose levels (r = −0.5, P = 0.04). In multivariate linear regression models, the increase in adiponectin as a dependent variable was significantly related to the decrease in hip circumference (β = −0.16, P = 0.028), after adjusting body mass index and waist circumference. The change in steady state plasma glucose levels as a dependent variable was related to the increase of adiponectin with a marginal significance (β =− 0.92, P = 0.053), after adjusting body mass index and waist and hip circumferences. In conclusion, body weight reduction increased the plasma levels of a protective adipocytokine, adiponectin. In addition, the increase in plasma adiponectin despite the reduction of the only tissue of its own synthesis suggests that the expression of adiponectin is under feedback inhibition in obesity.

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Authors: Yang, W.-S., Lee, W.-J., Funahashi, T., Tanaka, S., Matsuzawa, Y., Chao, C.-L., Chen, C.-L., Tai, T.-Y., & Chuang, L.-M.
Affiliations: Department of Internal Medicine (W.-S.Y., C.-L.C., T.-Y.T., L.-M.C.), Taipei 100
En Chu Kong Hospital (TW)
The University of Osaka (JP)
Department of Internal Medicine and Molecular Science (T.F., S.T., Y.M.), Graduate School of Medicine, Osaka University, 565-0871, Osaka, Japan
National Taiwan University (TW)
Corresponding author: Chuang, Lee-Ming
ORCID: Yang, Wei-Shiung
Tanaka, Sachiyo
Chen, Chi-Ling
Chuang, Lee-Ming
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 2001-08-01
Volume: 86
Issue: 8
Pages: 3815-3819
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jc.86.8.3815
OpenAlex: W2059582640
Cited by: 1,181
References: 26
Citations by year: 2026: 3 · 2025: 4 · 2024: 7 · 2023: 22 · 2022: 14 · 2021: 34 · 2020: 20 · 2019: 21 · 2018: 23 · 2017: 31 · 2016: 26 · 2015: 51 · 2014: 47 · 2013: 61 · 2012: 54
FWCI: 48.14
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: National Science Council (89-B-FA01-1-4)
National Taiwan University Hospital
National Taiwan University
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
Keywords: adiponectin, weight loss, bariatric surgery, gastric bypass, obesity, plasma adiponectin levels, adipokines, anti-inflammatory activity, body mass index, waist and hip circumference, plasma glucose, atherosclerosis, obesity-related disorders
MeSH terms: Adult, Blood Glucose, Body Constitution, Female, Gastrectomy, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Male, Models, Biological, Obesity, Proteins, Regression Analysis, Biomarkers, Weight Loss, Body Mass Index, Multivariate Analysis, Intercellular Signaling Peptides and Proteins, Adiponectin

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Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin

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