The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.
Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin
Abstract
Adiponectin, an adipose tissue-specific plasma protein, was recently revealed to have anti-inflammatory effects on the cellular components of vascular wall. Its plasma levels were significantly lower in men than in women and lower in human subjects with obesity, type 2 diabetes mellitus, or coronary artery disease. Therefore, it may provide a biological link between obesity and obesity-related disorders such as atherosclerosis, against which it may confer protection. In this study, we observed the changes of plasma adiponectin levels with body weight reduction among 22 obese patients who received gastric partition surgery. A 46% increase of mean plasma adiponectin level was accompanied by a 21% reduction in mean body mass index. The change in plasma adiponectin levels was significantly correlated with the changes in body mass index (r = −0.5, P = 0.01), waist (r = −0.4, P = 0.04) and hip (r =− 0.6, P = 0.0007) circumferences, and steady state plasma glucose levels (r = −0.5, P = 0.04). In multivariate linear regression models, the increase in adiponectin as a dependent variable was significantly related to the decrease in hip circumference (β = −0.16, P = 0.028), after adjusting body mass index and waist circumference. The change in steady state plasma glucose levels as a dependent variable was related to the increase of adiponectin with a marginal significance (β =− 0.92, P = 0.053), after adjusting body mass index and waist and hip circumferences. In conclusion, body weight reduction increased the plasma levels of a protective adipocytokine, adiponectin. In addition, the increase in plasma adiponectin despite the reduction of the only tissue of its own synthesis suggests that the expression of adiponectin is under feedback inhibition in obesity.
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“and increases the concentration of adiponectin 39”
From Absence of an Effect of Liposuction on Insulin Action and Risk Factors for Coronary Heart Disease (2004) · cites this paper as [39]
In the citing paper
“The obese are known to have increased insulin resistance and decreased adiponectin levels (12), which increase with weight loss (27).”
From Phenotypic effects of leptin replacement on morbid obesity, diabetes mellitus, hypogonadism, and behavior in leptin-deficient adults (2004) · cites this paper as [27]
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Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome
Kadowaki, T. (2006) · Journal of Clinical Investigation · doi:10.1172/jci29126 · Cited by 2,824
Esposito, K., Pontillo, A., Di Palo, C., Giugliano, G., Masella, M., Marfella, R., & Giugliano, D. (2003) · JAMA · doi:10.1001/jama.289.14.1799 · Cited by 1,511
Insulin and insulin resistance:
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Association of Hypoadiponectinemia With Coronary Artery Disease in Men
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Self-citationACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism
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Metadata
- Authors
- Yang, W.-S., Lee, W.-J., Funahashi, T., Tanaka, S., Matsuzawa, Y., Chao, C.-L., Chen, C.-L., Tai, T.-Y., & Chuang, L.-M.
- Affiliations
- Department of Internal Medicine (W.-S.Y., C.-L.C., T.-Y.T., L.-M.C.), Taipei 100
- En Chu Kong Hospital (TW)
- The University of Osaka (JP)
- Department of Internal Medicine and Molecular Science (T.F., S.T., Y.M.), Graduate School of Medicine, Osaka University, 565-0871, Osaka, Japan
- National Taiwan University (TW)
- Corresponding author
- Chuang, Lee-Ming
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 2001-08-01
- Volume
- 86
- Issue
- 8
- Pages
- 3815-3819
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2059582640
- Cited by
- 1,181
- References
- 26
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 7 · 2023: 22 · 2022: 14 · 2021: 34 · 2020: 20 · 2019: 21 · 2018: 23 · 2017: 31 · 2016: 26 · 2015: 51 · 2014: 47 · 2013: 61 · 2012: 54
- FWCI
- 48.14
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Science Council (89-B-FA01-1-4)
- National Taiwan University Hospital
- National Taiwan University
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adipokines, Inflammation, and Metabolic Diseases
- Health Sciences › Medicine › Physiology (medical) › Adipose Tissue and Metabolism
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Cardiovascular Disease and Adiposity
- Keywords
- adiponectin, weight loss, bariatric surgery, gastric bypass, obesity, plasma adiponectin levels, adipokines, anti-inflammatory activity, body mass index, waist and hip circumference, plasma glucose, atherosclerosis, obesity-related disorders
- MeSH terms
- Adult, Blood Glucose, Body Constitution, Female, Gastrectomy, Glucose Tolerance Test, Humans, Insulin, Insulin Resistance, Male, Models, Biological, Obesity, Proteins, Regression Analysis, Biomarkers, Weight Loss, Body Mass Index, Multivariate Analysis, Intercellular Signaling Peptides and Proteins, Adiponectin
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