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Dehydroepiandrosterone and androsterone levels in human plasma. Effect of age and sex: day-to-day and diurnal variations.
Abstract
METHODS have been described for the measurement of total 17-ketosteroids (17-KS) occurring in human plasma (1) and for their fractionation (2). Dehydroepiandrosterone (DHA) and androsterone have been isolated and found to be the principal 17-KS in the peripheral circulation of normal man (3, 4). The present study was carried out in order to obtain further information on the levels of DHA and androsterone in normal subjects and to ascertain the effect of age and sex on the concentrations of these steroids. It was also thought to be of interest to determine the diurnal variation as well as the day-to-day changes of the 17-KS levels in the same subjects. A 40-ml. sample of blood was drawn from each experimental subject between 8:30 and 9:30 a.m., except in the study of diurnal variations, when blood was obtained at various times of the day. The blood samples were heparinized. They were centrifuged within forty-five minutes following collection and the plasma was immediately separated from the red cells. When the determination was not carried out immediately, the plasma was kept in a freezer.
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In the citing paper
“Serum androgens as well as their precursors and metabolites decrease from the age of 30 -40 yr in women”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [22]
In the citing paper
“at 70 yr of age, serum DHEA-S levels are decreased to approximately 20% of their peak values, whereas they can decrease by 95% by the age of 85-90 yr (22).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [22]
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Labrie, F., Bélanger, A., Cusan, L., Gomez, J.-L., & Candas, B. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.8.4160 · Cited by 713
Baulieu, E.-E., Thomas, G., Legrain, S., Lahlou, N., Roger, M., Debuire, B., Faucounau, V., Girard, L., Hervy, M.-P., Latour, F., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.8.4279 · Cited by 577
Labrie, F., Luu-The, V., Labrie, C., Bélanger, A., Simard, J., Lin, S.-X., & Pelletier, G. (2003) · Endocrine Reviews · doi:10.1210/er.2001-0031 · Cited by 544
“In fact, as mentioned earlier, at 70 yr of age, serum DHEA-S levels are decreased to approximately 20% of their peak values, whereas they can decrease by 95% by the age of 85–90 yr (22).”
BackgroundIs dehydroepiandrosterone a hormone?
Labrie, F., Luu-The, V., Bèlanger, A., Lin, S.-X., Simard, J., Pelletier, G., & Labrie, C. (2005) · Journal of Endocrinology · doi:10.1677/joe.1.06264 · Cited by 460
“…physiology has removed attention from the dramatic 70% fall in circulating DHEA which already occurs between the ages of 20 to 30 and 40 to 50 years (Migeon et al. 1957, Vermeulen & Verdonck 1976, Vermeulen et al. 1982, Orentreich et al. 1984, Bélanger et al. 1994, Labrie et al. 1997d) (Fig.”
BackgroundInfluentialField, A. E., Colditz, G. A., Willett, W. C., Longcope, C., & McKinlay, J. B. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.5.7962322 · Cited by 421
Metadata
- Authors
- MIGEON, C. J., KELLER, A. R., LAWRENCE, B., & SHEPARD, T. H.
- Affiliations
- Johns Hopkins University (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1957-09
- Volume
- 17
- Issue
- 9
- Pages
- 1051-1062
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2144503086
- Cited by
- 260
- References
- 0
- Citations by year
- 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 2 · 2014: 3 · 2013: 4 · 2012: 4
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
- Keywords
- dehydroepiandrosterone, androsterone, 17-ketosteroids, plasma steroid levels, age differences, sex differences, diurnal variation, day-to-day variability
- MeSH terms
- Aging, Androgens, Androsterone, Circadian Rhythm, Dehydroepiandrosterone, Humans, Sex Characteristics, Sexual Maturation
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