Cited by 260Hormonal and reproductive studiesAdrenal Hormones and DisordersSexual Differentiation and Disorders

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Dehydroepiandrosterone and androsterone levels in human plasma. Effect of age and sex: day-to-day and diurnal variations.

MIGEON, CLAUDE J., KELLER, ANNE R., LAWRENCE, BETTY, SHEPARD, THOMAS H.·1957·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-17-9-1051

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Abstract

METHODS have been described for the measurement of total 17-ketosteroids (17-KS) occurring in human plasma (1) and for their fractionation (2). Dehydroepiandrosterone (DHA) and androsterone have been isolated and found to be the principal 17-KS in the peripheral circulation of normal man (3, 4). The present study was carried out in order to obtain further information on the levels of DHA and androsterone in normal subjects and to ascertain the effect of age and sex on the concentrations of these steroids. It was also thought to be of interest to determine the diurnal variation as well as the day-to-day changes of the 17-KS levels in the same subjects. A 40-ml. sample of blood was drawn from each experimental subject between 8:30 and 9:30 a.m., except in the study of diurnal variations, when blood was obtained at various times of the day. The blood samples were heparinized. They were centrifuged within forty-five minutes following collection and the plasma was immediately separated from the red cells. When the determination was not carried out immediately, the plasma was kept in a freezer.

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Result
Dehydroepiandrosterone: An anti‐obesity and anti‐carcinogenic agent
Schwartz, A. G., Hard, G. C., Pashko, L. L., Abou-Gharbia, M. A., & Swern, D. (1981) · Nutrition and Cancer · doi:10.1080/01635588109513700 · Cited by 63
DHEAS as an Effective Vaccine Adjuvant in Elderly Humans
Araneo, B. A., Dowell, T., Woods, M. L., Daynes, R. A., JUDD, M., & Evans, T. G. (1995) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1995.tb17384.x-i1 · Cited by 60
Dehydroepiandrosterone may be one of the regulators of cytokine production in atopic dermatitis
Tabata, N., Tagami, H., & Terui, T. (1997) · Archives of Dermatological Research · doi:10.1007/s004030050213 · Cited by 58
“... physiological functions have been ascribed to this steroid, many observations have indicated the existence of various biological responses to DHEA including susceptibility to infectious agents, immunosenescence, mucosal immunity [2], and antitumor and antidiabetic activities [3, 4]. DHEA shows intriguing biologica…”
Background
Life Extension
Schneider, E. L., & Reed, J. D. (1985) · New England Journal of Medicine · doi:10.1056/nejm198505023121805 · Cited by 56
Androgens and aging men
Baulieu, É.-É. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00367-2 · Cited by 58
Inhibition of the conversion of 3T3 fibroblast clones to adipocytes by dehydroepiandrosterone and related anticarcinogenic steroids.
Gordon, G., Newitt, J. A., Shantz, L. M., Weng, D. E., & Talalay, P. (1986) · PubMed · Cited by 57
Age-related decrease of dehydroepiandrosterone concentrations in low density lipoproteins and its role in the susceptibility of low density lipoproteins to lipid peroxidation
Khalil, A., Fortin, J. P., Lehoux, J., & Fülöp, T. (2000) · Journal of Lipid Research · doi:10.1016/s0022-2275(20)31987-8 · Cited by 57
Steroid Metabolism in the Fetoplacental Unit and in Early Childhood
Mitchell, F. L. (1967) · Vitamins and hormones · doi:10.1016/s0083-6729(08)60037-0 · Cited by 58
Effects of transforming growth factor-beta 1 on human adrenocortical fasciculata-reticularis cell differentiated functions
Lebrethon, M. C., Jaillard, C., Naville, D., Bégeot, M., & Saez, J. M. (1994) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.79.4.7962271 · Cited by 59
Serum levels of dehydroepiandrosterone and its sulfate and the risk of developing bladder cancer.
Gordon, G., Helzlsouer, K. J., & Comstock, G. W. (1991) · PubMed · Cited by 56
3β-HSD activates DHEA in the songbird brain
Schlinger, B. A., Pradhan, D. S., & Soma, K. K. (2007) · Neurochemistry International · doi:10.1016/j.neuint.2007.05.003 · Cited by 52
“1b) is an abundant circulating hormone in humans and, together with DHEA-S, constitutes the most abundant steroid hormone secreted by the human adrenal cortex (Migeon et al., 1957;Odell and Parker, 1984).”
Background
Relationship between the GH/IGF-I Axis, Insulin Sensitivity, and Adrenal Androgens in Normal Prepubertal and Pubertal Boys
Guercio, G., Rivarola, M. A., Chaler, E., Maceiras, M., & Belgorosky, A. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.3.8330 · Cited by 54
“1164 J Clin Endocrinol Metab, March 2002, 87(3):1162–1169 Guercio et al.”
BackgroundInfluential
The use of oral dehydroepiandrosterone sulfate as an adjuvant in tetanus and influenza vaccination of the elderly
Evans, T. G. (1996) · Vaccine · doi:10.1016/s0264-410x(96)00095-3 · Cited by 51
Protection by dehydroepiandrosterone in mice infected with viral encephalitis
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Measurements of Serum DHEA and DHEA Sulphate Levels Improve the Accuracy of the Low-Dose Cosyntropin Test in the Diagnosis of Central Adrenal Insufficiency
Kassem, L. S., Sibai, K. E., Chaiban, J. T., Abdelmannan, D. K., & Arafah, B. M. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-1806 · Cited by 50
“DHEA-S has a long half-life of around 20 h that provides constant levels throughout the day (15, 16), whereas DHEA has a shorter half-life of 1–3 h and has been shown to have less diurnal variation than cortisol (14).”
Background
Physicochemical characterization of [3H] DHEA binding in rat liver
Kalimi, M., & Regelson, W. (1988) · Biochemical and Biophysical Research Communications · doi:10.1016/s0006-291x(88)80800-3 · Cited by 50
Involvement of steroids and cytochromes P450 species in the triggering of immune defenses
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Modulation of immune dysfunction during murine leukaemia retrovirus infection of old mice by dehyroepiandrosterone sulphate (DHEAS)
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Radioligand assay for Δ5-3β-hydroxysteroids I. 3β-hydroxy-5-androstene-17-one and its 3-sulfate
Nieschlag, E., Loriaux, D. L., & LIPSETT, M. B. (1972) · Steroids · doi:10.1016/s0039-128x(72)80032-1 · Cited by 49
Dehydroepiandrosterone inhibits the proliferation of human umbilical vein endothelial cells by enhancing the expression of p53 and p21, restricting the phosphorylation of retinoblastoma protein, and is androgen‐ and estrogen‐receptor independent
Zapata, E., Ventura, J. L., la Cruz, K. D., Rodrı́guez, E., Damián, P., Massó, F., Montaño, L. F., & López‐Marure, R. (2005) · FEBS Journal · doi:10.1111/j.1742-4658.2005.04563.x · Cited by 48
Biology of Scalp Hair Growth
Orentreich∥, N., & Durr, N. P. (1982) · Clinics in Plastic Surgery · doi:10.1016/s0094-1298(20)30347-3 · Cited by 46
The Investigation of Steroid Metabolism in Early Infancy
Mitchell, F. L., & Shackleton, C. H. L. (1969) · Advances in clinical chemistry · doi:10.1016/s0065-2423(08)60259-0 · Cited by 46
Decrease in the expression of the 3β-hydroxysteroid dehydrogenase gene in human adrenal tissue during prepuberty and early puberty: implications for the mechanism of adrenarche
Dardis, A., Saraco, N., Rivarola, M. A., & Belgorosky, A. (1999) · Pediatric Research · doi:10.1203/00006450-199903000-00016 · Cited by 45

Authors: MIGEON, C. J., KELLER, A. R., LAWRENCE, B., & SHEPARD, T. H.
Affiliations: Johns Hopkins University (US)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1957-09
Volume: 17
Issue: 9
Pages: 1051-1062
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-17-9-1051
OpenAlex: W2144503086
Cited by: 260
References: 0
Citations by year: 2025: 1 · 2023: 2 · 2022: 1 · 2021: 1 · 2020: 2 · 2019: 3 · 2018: 4 · 2017: 4 · 2016: 2 · 2014: 3 · 2013: 4 · 2012: 4
FWCI: 3.58
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Sexual Differentiation and Disorders
Keywords: dehydroepiandrosterone, androsterone, 17-ketosteroids, plasma steroid levels, age differences, sex differences, diurnal variation, day-to-day variability
MeSH terms: Aging, Androgens, Androsterone, Circadian Rhythm, Dehydroepiandrosterone, Humans, Sex Characteristics, Sexual Maturation

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Dehydroepiandrosterone and androsterone levels in human plasma. Effect of age and sex: day-to-day and diurnal variations.

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