Cited by 640Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesPituitary Gland Disorders and Treatments

The DOI matches its Crossref record.

Age-related change in the twenty-four-hour spontaneous secretion of growth hormone

FINKELSTEIN, JORDAN W., ROFFWARG, HOWARD P., BOYAR, ROBERT M., KREAM, JACOB, HELLMAN, LEON·1972·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-35-5-665

Open this paper in CoChat — free account

Abstract

Spontaneous growth hormone secretion rates and secretory patterns were studied in a group of normal prepubertal children, adolescents and young and older adults by determining the concentration of growth hormone in plasma samples obtained at 20-min intervals over a 24-hr period. Prepubertal children secreted growth hormone only during sleep and not while awake and had a mean secretion rate of 91 μg/24 hr (range 54–122 μg/24 hr). Mean duration of secretion was 110 min/24 hr (range 60–180 min/24 hr). Adolescents secreted growth hormone during both awake and sleep periods and had a mean secretion rate of 690 μg/24 hr (range 391–1406 μg/24 hr). Mean duration of secretion was 226 min/24 hr (range 100–300 min/24 hr). Secretion rates in young adults (21–41 yr) averaged 385 μg/24 hr (range 215–769 μg/24 hr). Average duration of secretion was 133 min/24 hr (range 100–300 min/24 hr). Growth hormone was secreted during both awake and asleep periods but the number of secretory episodes was less than in adolescents. In older adults (42–62 yr) the total 24-hr secretion of growth hormone decreased and approached zero in three of five studies. These data clearly demonstrate an age related change in the spontaneous secretory rate and secretory pattern of growth hormone.

Integrity signals

Registry

Crossref · 10.1210/jcem-35-5-665

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 301–400 of 638

Age-related decrease in plasma growth hormone: Response to growth hormone-releasing hormone, arginine, and l-dopa in obesity
Tanaka, K., Inoue, S., Shiraki, J., et al. (1991) · Metabolism · doi:10.1016/0026-0495(91)90025-r · Cited by 27
1 Disorders of prolactin and growth hormone secretion
Ho, K. Y., Evans, W. S., & Thorner, M. O. (1985) · Clinics in Endocrinology and Metabolism · doi:10.1016/s0300-595x(85)80063-3 · Cited by 27
Emerging Anabolic Treatments for Osteoporosis
Rosen, C. J., & Rackoff, P. J. (2001) · Rheumatic Disease Clinics of North America · doi:10.1016/s0889-857x(05)70195-2 · Cited by 27
Diagnostic Value of Serum IGF-I and IGFBP-3 in Growth Hormone Disorders in Adults
Kim, H. J., Kwon, S. H., Kim, S. W., Park, D. J., Shin, C. S., Park, K. S., Kim, S. Y., Cho, B.-Y., & Lee, H. K. (2001) · Hormone Research in Paediatrics · doi:10.1159/000048103 · Cited by 27
Metabolic Interfaces between Growth and Reproduction. IV. Chronic Pulsatile Administration of Growth Hormone and the Timing of Puberty in the Female Sheep*
Suttie, J. M., Kostyo, J. L., Ebling, F. J. P., Wood, R. I., Bucholtz, D. C., Skottner, A., Adel, T. E., Towns, R., & Foster, D. L. (1991) · Endocrinology · doi:10.1210/endo-129-4-2024 · Cited by 27
Age- and Growth Hormone-Induced Alterations in Renal Sulfate Transport
Sagawa, K., Han, B., DuBois, D. C., et al. (1999) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1016/s0022-3565(24)35021-9 · Cited by 27
“The secretory rate and plasma concentrations of GH are age dependent (Finkelstein et al., 1972).”
Background
Neuroendocrine ageing
Björntorp, P. A. (1995) · Journal of Internal Medicine · doi:10.1111/j.1365-2796.1995.tb01217.x · Cited by 27
Prepubertal and Pubertal Endocrinology
Preece, M. A. (1986) · Springer eBooks · doi:10.1007/978-1-4899-0522-2_9 · Cited by 26
Interactive Regulation of Postmenopausal Growth Hormone Insulin-Like Growth Factor Axis by Estrogen and Growth Hormone-Releasing Peptide-2
Veldhuis, J. D., Evans, W. S., Bowers, C. Y., & Anderson, S. M. (2001) · Endocrine · doi:10.1385/endo:14:1:045 · Cited by 27
Regulation of the growth hormone (GH) receptor and GH-binding protein by GH pulsatility
Hochberg, Z., Phillip, M., Youdim, M. B. H., et al. (1993) · Metabolism · doi:10.1016/0026-0495(93)90159-l · Cited by 27
The neuroendocrinology of human sleep
Rubín, R. T., Poland, R. E., Rubin, L. E., & Gouin, P. R. (1974) · Life Sciences · doi:10.1016/0024-3205(74)90229-x · Cited by 27
Nonspecific Growth Hormone Responses to Thyrotropin-Releasing Hormone in Insulin-Dependent Diabetes: Sexand Age-Related Pituitary Responsiveness
Ceda, G. P., Speroni, G., Dall’Aglio, E., Valenti, G., & BUTTURINI, U. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-55-1-170 · Cited by 27
Pain coping strategies in children with juvenile primary fibromyalgia syndrome: Correlation with pain, physical function, and psychological distress
Schanberg, L. E., Kredich, D. W., Keefe, F. J., Lefebvre, J. C., & Gil, K. M. (1996) · Arthritis & Rheumatism · doi:10.1002/1529-0131(199604)9:2 · Cited by 80
Effects of growth hormone secretagogues on the release of adenohypophyseal hormones in young and old healthy dogs
Bhatti, S. F. M., Duchateau, L., Ham, L. M. L. V., et al. (2005) · The Veterinary Journal · doi:10.1016/j.tvjl.2005.04.025 · Cited by 26
“…generally accepted that basal GH secretion decreases in humans and animals with increasing age (Borst et al., 1994; De Genarro Colonna et al., 1994; Finkelstein et al., 1972; Sonntag et al., 1980; Wilshire et al., 1995; Zadik et al., 1985), the basal plasma GH concentration in our study was not…”
Background
The aging of the endocrine hypothalamus and its dependent endocrine glands
Batrinos, M. L. (2012) · HORMONES · doi:10.14310/horm.2002.1354 · Cited by 26
Neuroendocrine effects of quetiapine in healthy volunteers
Guerra, A. D. B. G., Castel, S., Benedito‐Silva, A. A., & Calil, H. M. (2005) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145704004705 · Cited by 26
Brain cortex phospholipids liposomes effects on CSF HVA, 5-HIAA and on prolactin and somatotropin secretion in man
Nizzo, M. C., Tegos, S., Gallaminia, A., et al. (1978) · Journal of Neural Transmission · doi:10.1007/bf01579068 · Cited by 26
Conventional and Nonconventional Uses of Growth Hormone
Lippe, B. M., & Nakamoto, J. M. (1993) · Elsevier eBooks · doi:10.1016/b978-0-12-571148-7.50011-7 · Cited by 27
Sleep for development or development for waking? — some speculations from a human perspective
Salzarulo, P., & Fagioli, I. (1995) · Behavioural Brain Research · doi:10.1016/0166-4328(95)00022-l · Cited by 26
Growth hormone therapy in elderly people: an age‐delaying drug?
Bouillanne, O., Rainfray, M., Tissandier, O., Nasr, A., Lahlou, A., Cnockaert, X., & Piette, F. (1996) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.1996.tb00596.x · Cited by 26
Neural Regulation of Growth Hormone Secretion
Martin, J. B. (1978) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)31809-0 · Cited by 26
Heterogeneity of growth hormone (GH)-producing cells in aging male rats: ultrastructure and GH gene expression in somatotrope subpopulations
Dobado‐Berrios, P. M., Ruiz‐Navarro, A., Almadén, Y., et al. (1996) · Molecular and Cellular Endocrinology · doi:10.1016/0303-7207(96)03781-1 · Cited by 26
Sixteen Weeks of Hexarelin Therapy in Aged Dogs: Effects on the Somatotropic Axis, Muscle Morphology, and Bone Metabolism
Cella, S. G., Cerri, C., Daniel, S., et al. (1996) · The Journals of Gerontology Series A · doi:10.1093/gerona/51a.6.b439 · Cited by 26
Pituitary and/or Peripheral Estrogen-Receptor α Regulates Follicle-Stimulating Hormone Secretion, Whereas Central Estrogenic Pathways Direct Growth Hormone and Prolactin Secretion in Postmenopausal Women
Cosma, M., Bailey, J. N., Miles, J. M., Bowers, C. Y., & Veldhuis, J. D. (2007) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2007-1322 · Cited by 26
Erg circadian rhythm in the course of ontogeny in crayfish
Fanjul‐Moles, M. L., Moreno‐Sáenz, E., Villalobos-Hiriart, N., et al. (1987) · Comparative Biochemistry and Physiology Part A Physiology · doi:10.1016/0300-9629(87)90472-5 · Cited by 25
Effect of Melatonin Injected into the Third Ventricle on Growth Hormone Secretion in Holstein Steers
Kasuya, E., KUSHIBIK, S., Sutoh, M., et al. (2006) · Journal of Veterinary Medical Science · doi:10.1292/jvms.68.1075 · Cited by 25
Endocrinological effects of mirtazapine in healthy volunteers
Schüle, C., Baghai, T. C., Bidlingmaier, M., Strasburger, C. J., & Laakmann, G. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00264-6 · Cited by 25
“Moreover, it has to be taken into account that GH shows pulsatile secretion patterns with spontaneous elevations of GH concentrations up to 20 ng/ ml and more that can lead to misinterpretation of the findings (Finkelstein et al., 1972).”
Background
Overnight Growth Hormone Secretion in Achondroplasia: Deconvolution Analysis, Correlation with Sleep State, and Changes after Treatment of Obstructive Sleep Apnea
Waters, K. A., Kirjavainen, T., Jimenez, M., Cowell, C. T. C. T., Sillence, D. O., & Sullivan, C. E. (1996) · Pediatric Research · doi:10.1203/00006450-199603000-00026 · Cited by 25
Skin Tensile Properties in Patients Treated for Acromegaly
Braham, C., Betea, D., Piérard-Franchimont, C., et al. (2002) · Dermatology · doi:10.1159/000063377 · Cited by 24
Testing with growth hormone-releasing factor (GRF(1–29)NH2) and somatomedin C measurements for the evaluation of growth hormone deficiency
Ranke, M. B., Gruhler, M., Rosskamp, R., et al. (1986) · European Journal of Pediatrics · doi:10.1007/bf02429048 · Cited by 24
The effect of developmental changes in adolescence on drug disposition
Finkelstein, J. W. (1994) · Journal of Adolescent Health · doi:10.1016/s1054-139x(94)90627-0 · Cited by 24
Self-citation
Circadian Rhythms of Blood Minerals during Adolescence
MARKOWITZ, M. E., Rosen, J. F., Laxminarayan, S., et al. (1984) · Pediatric Research · doi:10.1203/00006450-198405000-00013 · Cited by 24
The Endocrinology of Adolescence
Finkelstein, J. W. (1980) · Pediatric Clinics of North America · doi:10.1016/s0031-3955(16)33819-6 · Cited by 24
Self-citation
Growth hormone secretion in response to glucagon stimulation test in healthy middle-aged men
Micmacher, E., Assumpção, R. P., Redorat, R. G., Spina, L. D. C., Cruz, I. C., Silva, C. A., Vaisman, M., & Conceição, F. L. (2009) · Arquivos Brasileiros de Endocrinologia & Metabologia · doi:10.1590/s0004-27302009000700009 · Cited by 22
Growth hormone treatment of idiopathic short stature: analysis of the database from KIGS, the Kabi Pharmacia International Growth Study
Ranke, M., Lindberg, A., & On behalf of the International Board of the Kabi Pharmacia International Growth Study (1994) · Acta Paediatrica · doi:10.1111/j.1651-2227.1994.tb13415.x · Cited by 23
Aging of the Human Endocrine and Neuroendocrine Time Structurea
Touitou, Y., & Haus, E. L. (1994) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1994.tb56844.x · Cited by 23
GROWTH HORMONE IN HUMAN PREGNANCY
Eriksson, L. (1987) · Acta Obstetricia Et Gynecologica Scandinavica · doi:10.3109/00016348709156496 · Cited by 23
Variability in growth hormone stimulation tests
Fisker, S., Jørgensen, J. O. L., & Christiansen, J. S. (1998) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(98)80006-3 · Cited by 23
Mechanisms of Age-Related Endocrine Alterations
Mooradian, A. D. (1993) · Drugs & Aging · doi:10.2165/00002512-199303020-00004 · Cited by 24
Combined deficits in the somatotropic and gonadotropic axes in healthy aging men: An appraisal of neuroendocrine mechanisms by deconvolution analysis
Veldhuis, J. D., Iranmanesh, A., LIZARRALDE, G., & Urban, R. J. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90089-2 · Cited by 23
Episodic growth hormone secretion in the domestic fowl (Gallus domesticus): Alpha adrenergic regulation
BUONOMO, F. C., Lauterio, T. J., & Scanes, C. G. (1984) · Comparative Biochemistry and Physiology Part C Comparative Pharmacology · doi:10.1016/0742-8413(84)90107-5 · Cited by 23
Sleep and neuroendocrine correlates of affective illness in childhood and adolescence
Puig-Antich, J. (1987) · Journal of Adolescent Health Care · doi:10.1016/0197-0070(87)90051-9 · Cited by 22
Differential Diagnosis of the Short IGF-I-Deficient Child with Apparently Normal Growth Hormone Secretion
Wit, J. M., Joustra, S. D., Losekoot, M., van Duyvenvoorde, H. A., & de Bruin, C. (2021) · Hormone Research in Paediatrics · doi:10.1159/000516407 · Cited by 22
Elderly people with hypothalamic–pituitary disease and growth hormone deficiency: lipid profiles, body composition and quality of life compared with control subjects
Chong, J. S. W. L. V., Benbow, S. J., Foy, P. M., Wallymahmed, M., Wile, D. B., & MacFarlane, I. A. (2000) · Clinical Endocrinology · doi:10.1046/j.1365-2265.2000.01140.x · Cited by 22
“, 1991) and some studies suggest that GH secretion may eventually cease in certain elderly patients (Finkelstein et al., 1972).”
BackgroundInfluential
Racial and socioeconomic: Influences in anorexia nervosa and bulimia
Andersen, A. E., & Hay, A. (1985) · International Journal of Eating Disorders · doi:10.1002/1098-108x(198511)4:4 · Cited by 77
Somatomedin-C and Growth in Children with Precocious Puberty: A Study of the Effect of the Level of Growth Hormone Secretion*
Rappaport, R., Prévôt, C., & Brauner, R. (1987) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-65-6-1112 · Cited by 22
TALL STATURE: A CLINICAL, ENDOCRINOLOGICAL AND RADIOLOGICAL STUDY
Hindmarsh, P. C., Stanhope, R. G., Kendall, B. E., et al. (1986) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1986.tb01686.x · Cited by 22
Reliability of Estimates of Pulsatile Characteristics of Luteinizing Hormone and Growth Hormone Release in Women*
Weltman, J. Y., Veldhuis, J. D., WELTMAN, A. L., Kerrigan, J. R., Evans, W. S., & Rogol, A. D. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-71-6-1646 · Cited by 22
Pulsatility of Immunoreactive Somatomedin-C in Chronically Cannulated Rats*
Baxter, R. C., ZALTSMAN, Z., Oliver, J. R., et al. (1983) · Endocrinology · doi:10.1210/endo-113-2-729 · Cited by 22
Joint Mechanisms of Impaired Growth-Hormone Pulse Renewal in Aging Men
Veldhuis, J. D., Iranmanesh, A., & Bowers, C. Y. (2005) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2005-0336 · Cited by 22
Recombinant growth hormone: A new cardiovascular drug therapy
Gomberg‐Maitland, M., & Frishman, W. H. (1996) · American Heart Journal · doi:10.1016/s0002-8703(96)90469-x · Cited by 21
Growth, Growth Hormone and the Somatomedins: A Historical Perspective and Current Concepts
Rudd, B. T. (1991) · Annals of Clinical Biochemistry International Journal of Laboratory Medicine · doi:10.1177/000456329102800603 · Cited by 21
Growth Hormone, Insulin-like Growth Factors
Wüster, C. C., & Rosen, C. J. (2001) · Elsevier eBooks · doi:10.1016/b978-012470862-4/50079-9 · Cited by 21
Growth hormone and aging: Regulation, signal transduction and replacement therapy
Xu, X., & Sonntag, W. E. (1996) · Trends in Endocrinology and Metabolism · doi:10.1016/1043-2760(96)00043-4 · Cited by 22
Elemental Analysis of Aging Human Pituitary Glands Implicates Mercury as a Contributor to the Somatopause
Pamphlett, R., Jew, S. K., Doble, P., & Bishop, D. (2019) · Frontiers in Endocrinology · doi:10.3389/fendo.2019.00419 · Cited by 21
“(2) It is difficult to obtain enough human pituitary autopsy samples, together with detailed clinical data and biochemical analyses of growth hormone secretion, to allow a comprehensive examination of the effects of mercury on growth hormone levels throughout life.”
Background
Growth hormone response to a standardised exercise test in relation to puberty and stature.
Greene, S. A., Torresani, T., & Prader, A. (1987) · Archives of Disease in Childhood · doi:10.1136/adc.62.1.53 · Cited by 20
Growth Hormone, Prolactin and Cortisol Responses and Growth Patterns in Hyperkinetic Children Treated with Dextro-Amphetamine: Preliminary Findings
Puig-Antich, J., Greenhill, L. L., Sassin, J. F., & Sachar, E. J. (1978) · Journal of the American Academy of Child Psychiatry · doi:10.1016/s0002-7138(09)62301-3 · Cited by 20
Biosocial correlates of stature in a 16-year-old British cohort
Terrell, T. R., & Mascie‐Taylor, C. G. N. (1991) · Journal of Biosocial Science · doi:10.1017/s0021932000019507 · Cited by 20
Rhythms of Protein Synthesis and Other Circahoralian Oscillations: The Possible Involvement of Fractals
Brodsky, V. Y. (1992) · Springer eBooks · doi:10.1007/978-1-4471-1969-2_2 · Cited by 20
Relationships between insulin-like growth hormone factor-I and estradiol in reproductive aging
Blake, E. J., Adel, T. E., & Santoro, N. F. (1997) · Fertility and Sterility · doi:10.1016/s0015-0282(97)81369-6 · Cited by 20
Pulsatile secretion pattern of growth hormone in turkeys: Effects of age and sex
Shaw, S., Bacon, W. L., VASILATOS-YOUNKEN, R., et al. (1987) · General and Comparative Endocrinology · doi:10.1016/0016-6480(87)90045-1 · Cited by 20
Parathyroid Physiology and Primary Hyperparathyroidism
Habener, J. F., & Potts, J. T. J. (1978) · Elsevier eBooks · doi:10.1016/b978-0-12-068702-2.50007-6 · Cited by 20
Biosynthesis of Growth Hormone and Insulin-Like Growth Factor-I and the Regulation of their Secretion
Skottner, A. (2012) · The Open Endocrinology Journal · doi:10.2174/1874216501206010003 · Cited by 19
Neuroendocrine Alterations in the Somatotropic Axis in Chronic Renal Failure
Veldhuis, J. D., Johnson, M. L., Wilkowski, M. J., Iranmanesh, A., & Bolton, W. K. (1991) · Acta Paediatrica · doi:10.1111/j.1651-2227.1991.tb12037.x · Cited by 18
Diagnostic Validity of 12-Hour Integrated Concentration of Growth Hormone
Richards, G. E. (1987) · Archives of Pediatrics and Adolescent Medicine · doi:10.1001/archpedi.1987.04460050095039 · Cited by 19
Disturbed Pubertal Growth in Girls after Acute Leukaemia: a Relative Growth Hormone Insufficiency with Late Presentation
Moëll, C. (1988) · Acta Paediatrica · doi:10.1111/j.1651-2227.1988.tb10817.x · Cited by 19
Changes in Hypothalamic Hypophysiotropic Hormones and Neurotransmitters during Aging
Simpkins, J. W. (1983) · Springer eBooks · doi:10.1007/978-1-4684-4523-7_4 · Cited by 20
GROWTH HORMONE SECRETION RELATED TO THE SLEEP AND WAKING RHYTHM
Takahashi, Y. (1979) · Elsevier eBooks · doi:10.1016/b978-0-12-222340-2.50011-2 · Cited by 20
Role of Gorwth Hormone in Ovarian Physiology and Onest of Puberty
Sharara, F. I., & Giudice, L. C. (1997) · Journal of the Society for Gynecologic Investigation · doi:10.1016/s1071-5576(96)00059-7 · Cited by 18
Physiological determinants of the variation in left ventricular mass from early adolescence to late adulthood in healthy subjects
Cain, P. A., Ahl, R., Hedström, E., et al. (2007) · Clinical Physiology and Functional Imaging · doi:10.1111/j.1475-097x.2007.00735.x · Cited by 18
CHOLINERGIC MUSCARINIC BLOCKADE PRODUCES SHORT‐TERM SUPPRESSION OF GROWTH HORMONE SECRETION IN CHILDREN WITH TALL STATURE
Hindmarsh, P. C., Pringle, P. J., & Brook, C. G. D. (1988) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1988.tb01227.x · Cited by 18
Evaluation of Cutaneous Modifications in Seventy-Seven Growth Hormone-Deficient Children
Conte-Auriol, F., Diridollou, S., Jouret, B., Turlier, V., Charvéron, M., Gall, Y., ROCHICCIOLI, P. E., Bieth, É., & Tauber, M. (2000) · Hormone Research in Paediatrics · doi:10.1159/000053238 · Cited by 18
Laughing Seizures and Precocious Puberty
Penfold, J. L., Manson, J. I., & CALDICOTT, W. M. (1978) · Journal of Paediatrics and Child Health · doi:10.1111/jpc.1978.14.3.185 · Cited by 18
PHYSIOLOGICAL GROWTH HORMONE SECRETION DURING SLOW‐WAVE SLEEP IN SHORT PREPUBERTAL CHILDREN
Adlard, P., Buzi, F., JONES, J., Stanhope, R. G., & Preece, M. A. (1987) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1987.tb01162.x · Cited by 18
Growth hormone and thyrotropin secretory profiles and provocative testing in aged rats
Millard, W. J., Romano, T. M., & Simpkins, J. W. (1990) · Neurobiology of Aging · doi:10.1016/0197-4580(90)90550-j · Cited by 18
The Potential Role of Selected Endocrine Systems in Aging Processes
Nelson, J. F. (1995) · Comprehensive physiology · doi:10.1002/cphy.cp110115 · Cited by 19
Sex Steroids, GHRH, Somatostatin, IGF-I, and IGFBP-1 Modulate Ghrelin's Dose-Dependent Drive of Pulsatile GH Secretion in Healthy Older Men
Veldhuis, J. D., Norman, C., Miles, J. M., & Bowers, C. Y. (2012) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2012-2567 · Cited by 18
Sleep and Intensive Care Unit–Acquired Weakness in Critically Ill Older Adults
Elias, M. N., Munro, C. L., Liang, Z., Calero, K., & Ji, M. (2018) · Dimensions of Critical Care Nursing · doi:10.1097/dcc.0000000000000335 · Cited by 17
Predicting and Monitoring of Growth in Children with Short Stature during the First Year of Growth Hormone Treatment
Mortensen, H. B., Main, K. M., Michaelsen, K. F., et al. (1991) · Acta Paediatrica · doi:10.1111/j.1651-2227.1991.tb11803.x · Cited by 17
Increased growth hormone response to clonidine in nonobese normoinsulinemic patients with polycystic ovary syndrome
Comim, F. V., & Spritzer, P. M. (2004) · Fertility and Sterility · doi:10.1016/j.fertnstert.2003.05.027 · Cited by 17
Insulin-like growth factor-I in man enhances lipid mobilization and oxidation induced by a growth hormone pulse
Bianda, T., Hussain, M. A., Keller, A., Glatz, Y., Schmitz, O., Christiansen, J. S., Alberti, K. G. M. M., & Froesch, E. R. (1996) · Diabetologia · doi:10.1007/bf00403916 · Cited by 16
“GH secretion, regulated by a complex neuroendocrine system including neurotransmitters and feedback by hormones and metabolic substrates, is known to be pulsatile [1, 2], physiologically related to sleep, activity, stress and nutrient intake, with low basal serum levels between the peaks, at all stages of life.”
Background
Effects of growth hormone-releasing peptides in healthy dogs and in dogs with pituitary-dependent hyperadrenocorticism
Bhatti, S. F. M., Vliegher, S. P. D., Ham, L. V., et al. (2002) · Molecular and Cellular Endocrinology · doi:10.1016/s0303-7207(02)00293-9 · Cited by 17
Central Regulation of Growth Hormone Secretion
Millard, W. J. (1989) · Springer eBooks · doi:10.1007/978-1-4684-8872-2_11 · Cited by 17
Physiological growth hormone secretion in adult growth hormone deficiency: comparison with normal controls
Whitehead, H. M., Aikent, B., LEWIS, S. A., Sheridan, B., & Haddon, D. R. (1991) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1991.tb00307.x · Cited by 16
“Some investigators have failed to demonstrate a nocturnal surge of GH in normal adults aged over 50 years (Carlson et al., 1972; Finkelstein et al., 1972).”
Background
Estimates of Repeatability in the Temporal Patterns of Secretion of Growth Hormone (GH), Prolactin (PRL) and Thyrotropin (TSH) in Sheep3
Davis, S. L., Ohlson, D. L., Klindt, J., et al. (1979) · Journal of Animal Science · doi:10.2527/jas1979.493724x · Cited by 17
Neuroendocrine circuit for sleep-dependent growth hormone release
Ding, X., Hwang, F.-J., Silverman, D., Zhong, P., Li, B., Ma, C., Lu, L., Jiang, G., Zhang, Z., Huang, X., et al. (2025) · Cell · doi:10.1016/j.cell.2025.05.039 · Cited by 22
Growth Hormone Axis and Aging
Nass, R. M. (2013) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2013.02.001 · Cited by 16
“Several studies also show that the alterations in body composition with aging are similar to those observed in adult GH deficiency.(27,29,30,34)”
BackgroundResult
Effects of Growth Hormone Treatment on Lipid Profiles
Kubo, T., Furujo, M., Takahashi, K., Hyodo, Y., Tsuchiya, H., Hattori, M., Fujinaga, S., & Urayama, K. (2017) · The Indian Journal of Pediatrics · doi:10.1007/s12098-017-2509-8 · Cited by 16
Nocturnal Growth Hormone Secretion in Depressed Older Adolescents
Kutcher, S., Williamson, P., Silverberg, J., Marton, P., Malkin, D., & Malkin, A. (1988) · Journal of the American Academy of Child & Adolescent Psychiatry · doi:10.1097/00004583-198811000-00015 · Cited by 16
Neuroendocrine Secretion and Biological Rhythms in Man
Wagner, D. R., & Weitzman, E. D. (1980) · Psychiatric Clinics of North America · doi:10.1016/s0193-953x(18)30964-x · Cited by 16
Effects of photoperiod on the secretion of growth hormone in female goats
Jin, J. I. N., Yaegashi, T., Sawai, K., et al. (2012) · Animal Science Journal · doi:10.1111/j.1740-0929.2011.00998.x · Cited by 15
“Spontaneous GH secretion shows a distinct increase during the night in humans (Finkelstein et al. 1972; Hartman et al. 1993), monkeys (Kaler et al.”
Background
Body Composition and Circulating Levels of Insulin, Insulin-Like Growth Factor-Binding Protein-1 and Growth Hormone (GH)-Binding Protein Affect the Pharmacokinetics of GH in Adults Independently of Age
Hansen, T. K., Jørgensen, J. O. L., & Christiansen, J. S. (2002) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.87.5.8473 · Cited by 15
The growth hormone response to pyridostigmine plus growth hormone releasing hormone is not influenced by pubertal maturation
Cappa, M., Loche, S., Salvatori, R., Faedda, A., Borrelli, P., Cella, S. G., Pintor, C., & Müller, E. E. (1991) · Journal of Endocrinological Investigation · doi:10.1007/bf03350258 · Cited by 15
Sleep-Endocrinology Studies in Man
Rubín, R. T. (1975) · Progress in brain research · doi:10.1016/s0079-6123(08)63646-8 · Cited by 15
The Role of the Limbic System in Neuroendocrine Regulation
Willoughby, J. O., & Martin, J. B. (1978) · Springer eBooks · doi:10.1007/978-1-4757-0716-8_9 · Cited by 15
Growth Hormone Release in Conscious Pinealectomized and Sham-Operated Male Rats*
RONNELKEIV, O. K., & McCann, S. M. (1978) · Endocrinology · doi:10.1210/endo-102-6-1694 · Cited by 15
Effects of aging on pituitary growth hormone-releasing factor receptor binding sites: in vitro mimicry by guanyl nucleotides and reducing agents
Lefrançois, L., Boulanger, L., & Gaudreau, P. (1995) · Brain Research · doi:10.1016/0006-8993(94)01392-u · Cited by 15
ALTERATION IN THE NOCTURNAL PULSATILE RELEASE OF GH DURING THE INDUCTION OF PUBERTY USING LOW DOSE PULSATILE LHRH: A CASE REPORT
Stanhope, R. G., Pringle, P. J., & Brook, C. G. D. (1985) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1985.tb01071.x · Cited by 15
Metabolic Status and Growth Hormone Secretion in Man
Vance, M. L. (1993) · Journal of Pediatric Endocrinology and Metabolism · doi:10.1515/jpem.1993.6.3-4.267 · Cited by 15
Insulin-like growth factor-1 and cognitive health: Exploring cellular, preclinical, and clinical dimensions
Hayes, C. A., Wilson, D., Leon, M. A. D., Mustapha, M. J., Morales, S., Odden, M. C., & Ashpole, N. M. (2024) · Frontiers in Neuroendocrinology · doi:10.1016/j.yfrne.2024.101161 · Cited by 14

Authors: FINKELSTEIN, J. W., ROFFWARG, H. P., BOYAR, R. M., KREAM, J., & HELLMAN, L.
Affiliations: Montefiore Medical Center (US)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1972-11
Volume: 35
Issue: 5
Pages: 665-670
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-35-5-665
OpenAlex: W1997993870
Cited by: 640
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 13
FWCI: 7.61
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords: growth hormone secretion, age-related changes, prepubertal children, adolescents, young adults, older adults
MeSH terms: Adolescent, Adult, Age Factors, Child, Circadian Rhythm, Female, Humans, Male, Middle Aged, Secretory Rate, Sleep Stages, Growth Hormone, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Age-related change in the twenty-four-hour spontaneous secretion of growth hormone

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks