Cited by 640Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesPituitary Gland Disorders and Treatments

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Age-related change in the twenty-four-hour spontaneous secretion of growth hormone

FINKELSTEIN, JORDAN W., ROFFWARG, HOWARD P., BOYAR, ROBERT M., KREAM, JACOB, HELLMAN, LEON·1972·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-35-5-665

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Abstract

Spontaneous growth hormone secretion rates and secretory patterns were studied in a group of normal prepubertal children, adolescents and young and older adults by determining the concentration of growth hormone in plasma samples obtained at 20-min intervals over a 24-hr period. Prepubertal children secreted growth hormone only during sleep and not while awake and had a mean secretion rate of 91 μg/24 hr (range 54–122 μg/24 hr). Mean duration of secretion was 110 min/24 hr (range 60–180 min/24 hr). Adolescents secreted growth hormone during both awake and sleep periods and had a mean secretion rate of 690 μg/24 hr (range 391–1406 μg/24 hr). Mean duration of secretion was 226 min/24 hr (range 100–300 min/24 hr). Secretion rates in young adults (21–41 yr) averaged 385 μg/24 hr (range 215–769 μg/24 hr). Average duration of secretion was 133 min/24 hr (range 100–300 min/24 hr). Growth hormone was secreted during both awake and asleep periods but the number of secretory episodes was less than in adolescents. In older adults (42–62 yr) the total 24-hr secretion of growth hormone decreased and approached zero in three of five studies. These data clearly demonstrate an age related change in the spontaneous secretory rate and secretory pattern of growth hormone.

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Authors: FINKELSTEIN, J. W., ROFFWARG, H. P., BOYAR, R. M., KREAM, J., & HELLMAN, L.
Affiliations: Montefiore Medical Center (US)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1972-11
Volume: 35
Issue: 5
Pages: 665-670
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-35-5-665
OpenAlex: W1997993870
Cited by: 640
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 13
FWCI: 7.61
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords: growth hormone secretion, age-related changes, prepubertal children, adolescents, young adults, older adults
MeSH terms: Adolescent, Adult, Age Factors, Child, Circadian Rhythm, Female, Humans, Male, Middle Aged, Secretory Rate, Sleep Stages, Growth Hormone, Time Factors

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Age-related change in the twenty-four-hour spontaneous secretion of growth hormone

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