Cited by 640Growth Hormone and Insulin-like Growth FactorsHypothalamic control of reproductive hormonesPituitary Gland Disorders and Treatments

The DOI matches its Crossref record.

Age-related change in the twenty-four-hour spontaneous secretion of growth hormone

FINKELSTEIN, JORDAN W., ROFFWARG, HOWARD P., BOYAR, ROBERT M., KREAM, JACOB, HELLMAN, LEON·1972·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-35-5-665

Open this paper in CoChat — free account

Abstract

Spontaneous growth hormone secretion rates and secretory patterns were studied in a group of normal prepubertal children, adolescents and young and older adults by determining the concentration of growth hormone in plasma samples obtained at 20-min intervals over a 24-hr period. Prepubertal children secreted growth hormone only during sleep and not while awake and had a mean secretion rate of 91 μg/24 hr (range 54–122 μg/24 hr). Mean duration of secretion was 110 min/24 hr (range 60–180 min/24 hr). Adolescents secreted growth hormone during both awake and sleep periods and had a mean secretion rate of 690 μg/24 hr (range 391–1406 μg/24 hr). Mean duration of secretion was 226 min/24 hr (range 100–300 min/24 hr). Secretion rates in young adults (21–41 yr) averaged 385 μg/24 hr (range 215–769 μg/24 hr). Average duration of secretion was 133 min/24 hr (range 100–300 min/24 hr). Growth hormone was secreted during both awake and asleep periods but the number of secretory episodes was less than in adolescents. In older adults (42–62 yr) the total 24-hr secretion of growth hormone decreased and approached zero in three of five studies. These data clearly demonstrate an age related change in the spontaneous secretory rate and secretory pattern of growth hormone.

Integrity signals

Registry

Crossref · 10.1210/jcem-35-5-665

Cites

Statistics

Recomputing p-values needs the paper’s full text.

Claims the paper makes

This paper’s full text isn’t openly available, so its claims and self-check weren’t run. The registry and citation checks still apply.

Claims other papers make about this one

Each is checked against this paper’s own text: does it say what the citing paper says it does?

Sorted by citations

Items 401–500 of 638

Effects of photoperiod on the secretion of growth hormone and prolactin during nighttime in female goats
Jin, J. I. N., Yaegashi, T., & HASHIZUME, T. (2012) · Animal Science Journal · doi:10.1111/j.1740-0929.2012.01050.x · Cited by 14
Introduction to Pediatric Sleep Medicine
Sheldon, S. H. (2005) · Elsevier eBooks · doi:10.1016/b978-0-7216-9458-0.50006-4 · Cited by 16
Reliability of clonidine testing for the diagnosis of growth hormone deficiency in children and adolescents
Ibba, A., Guzzetti, C., Casula, L., Salerno, M., Iorgi, N. D., Allegri, A. E. M., Cappa, M., Maghnie, M., & Loche, S. (2018) · Clinical Endocrinology · doi:10.1111/cen.13845 · Cited by 14
Interactions Between Growth Hormone Secretion and Sleep
Cauter, E. V., & Copinschi, G. (2000) · Humana Press eBooks · doi:10.1007/978-1-59259-015-5_16 · Cited by 13
Mechanisms of Growth Retardation, Drug Therapy, and Nutritional Support in Pediatric Inflammatory Bowel Disease: A Workshop Sponsored by the North American and European Societies for Pediatric Gastroenterology and Nutrition
Ferry, G. D., Ferry, G. D., & Büller, H. A. (1995) · Inflammatory Bowel Diseases · doi:10.1097/00054725-199512000-00012 · Cited by 14
Hypothalamic control of GH secretion: Pathophysiology and clinical implications
QUABBE, H.-J. (1985) · Acta Neurochirurgica · doi:10.1007/bf01406324 · Cited by 14
Age-related alterations in gonadotropin, adrenocorticotropin and growth hormone secretion
Cocchi, D. (1992) · Aging Clinical and Experimental Research · doi:10.1007/bf03324075 · Cited by 14
OVERNIGHT URINARY GROWTH HORMONE MEASUREMENT IN THE DIAGNOSIS OF ACROMEGALY
Lunt, H., TUCKER, J., Bullen, H., et al. (1990) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1990.tb00484.x · Cited by 14
Effect of Growth Hormone Suppression on Exercise Training and Growth Responses in Young Rats
Cooper, D. M., Moromisato, D. Y., Zanconato, S., Moromisato, M. Y., Jensen, S., & Brasel, J. A. (1994) · Pediatric Research · doi:10.1203/00006450-199402000-00020 · Cited by 15
Potential Therapeutic Indications for Growth Hormone and Growth Hormone‐releasing Hormone in Conditions other than Growth Retardation
Williams, T. C., & Frohman, L. A. (1986) · Pharmacotherapy The Journal of Human Pharmacology and Drug Therapy · doi:10.1002/j.1875-9114.1986.tb03493.x · Cited by 14
Diagnosis of Growth Hormone (GH) Deficiency and the Use of GH in Children with Growth Disorders
Juul, A., Bernasconi, S., Chatelain, P., Hindmarsh, P. C., Hochberg, Z., Hokken-Koelega, A., Keizer‐Schrama, S. M. P. F. D. M., Kiess, W., Oberfield, S. E., Parks, J. S., et al. (1999) · Hormone Research in Paediatrics · doi:10.1159/000023416 · Cited by 14
“Dosage No consensus exists on how to express GH dosage, as some countries calculate dosage according to body surface area (m 2 ) and others according to body weight (kg). The actual dosage will in most cases be lower if calculated according to body surface area. A starting dose of 2 IU/m 2 /day (0.07 IU/kg/day) will p…”
BackgroundInfluential
Serum growth hormone levels in schizophrenic patients during sleep
Syv�lahti, E., & Pekkarinen, A. (1977) · Journal of Neural Transmission · doi:10.1007/bf01300136 · Cited by 14
Diurnal patterns of secretion of cortisol and growth hormone in normal adolescents, in patients with exogenous and endogenous Cushing's syndrome, in patients with diabetes mellitus, and in a fasting subject
Vazquez, A. M., Schutt-Ainé, J. C., DRASH, A. L., Kenny, F. M., Richards, C., & Anthony, D. (1973) · The Journal of Pediatrics · doi:10.1016/s0022-3476(73)80218-5 · Cited by 14
The onset of female puberty: underlying neuroendocrine mechanisms
Ojeda, S. R., Smith, S. S., Urbanski, H. F., et al. (1984) · Elsevier eBooks · doi:10.1016/b978-0-444-90377-8.50010-7 · Cited by 14
A Determinant of Stature: Regulation of Growth Hormone Secretion
Bercu, B. B., & Diamond, F. (1986) · Advances in Pediatrics · doi:10.1016/s0065-3101(24)00311-6 · Cited by 14
Reduced Insulin-Like Growth Factor-I Serum Levels in Formerly Obese Women Subjected to Laparoscopic-Adjustable Gastric Banding or Diet-Induced Long-term Caloric Restriction
Mitterberger, M. C., Mattesich, M., Klaver, E., Piza‐Katzer, H., & Zwerschke, W. (2011) · The Journals of Gerontology Series A · doi:10.1093/gerona/glr149 · Cited by 13
“Beginning in early adulthood, circulating GH and IGF-I levels decline strongly with age, and relatively low GH and IGF-I serum levels are characteristics of normal aging (70,71).”
Background
Methods of Evaluating Spontaneous Growth Hormone Secretion
Albertsson-Wikland, K. G., & Rosberg, S. (2003) · KARGER eBooks · doi:10.1159/000073548 · Cited by 13
Levels of human and rat hypothalamic growth hormone-releasing factor as determined by specific radioimmunoassay systems.
AUDHYA, T. K., Manzione, M. M., Nakane, T., et al. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.9.2970 · Cited by 13
Chronobiology of Development and Aging
Haus, E. L., & Touitou, Y. (1997) · Handbook of experimental pharmacology · doi:10.1007/978-3-662-09355-9_5 · Cited by 13
Morphometric analysis of somatotrophs: Effects of age and dietary restriction
Shimokawa, I., Yu, B. P., Higami, Y., et al. (1996) · Neurobiology of Aging · doi:10.1016/0197-4580(95)02028-4 · Cited by 13
Physiological Testosterone Replenishment in Healthy Elderly Men Does Not Normalize Pituitary Growth Hormone Output: Evidence against the Connection between Senile Hypogonadism and Somatopause
Orrego, J. J., Dimaraki, E. V., Symons, K., & Barkan, A. L. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031530 · Cited by 13
Changes in Serum Immunoreactive and Bioactive Growth Hormone Concentrations in Boys with Advancing Puberty and in Response to a 20-Hour Estradiol Infusion
Cemeroğlu, A. P., Barkan, A. L., Kletter, G. B., Beitins, I. Z., & Foster, C. M. (1997) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.82.7.4076 · Cited by 13
Changes in Growth Hormone Secretion in Aging Rats and Man, and Possible Relation to Diminished Physiological Functions
Sonntag, W. E., FORMAN, L. J., & Meites, J. (1983) · Springer eBooks · doi:10.1007/978-1-4684-4523-7_14 · Cited by 14
CHANGES IN ENDOGENOUS INSULIN SECRETION DURING CHILDHOOD AS EXPRESSED BY PLASMA AND URINARY C‐PEPTIDE
Laron, Z., Aurbach-Klipper, Y., Flasterstein, B., Litwin, A., Dickerman, Z., & Hedïng, L. G. (1988) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1988.tb03710.x · Cited by 13
Nasal Absorption of Growth Hormone in Normal Subjects: Studies with Four Different Formulations
Laursen, T., Ovesen, P., Grandjean, B., et al. (1994) · Annals of Pharmacotherapy · doi:10.1177/106002809402800703 · Cited by 13
Medium-chain triglycerides (8:0 and 10:0) increase muscle mass and function in frail older adults: a combined data analysis of clinical trials
Ezaki, O., & Abe, S. (2023) · Frontiers in Nutrition · doi:10.3389/fnut.2023.1284497 · Cited by 12
The Pituitary Gland: Anatomy, Physiology, and its Function as the Master Gland
Barkhoudarian, G., & Kelly, D. F. (2017) · Elsevier eBooks · doi:10.1016/b978-0-12-804340-0.00001-2 · Cited by 17
Augmentation of Growth Hormone Secretion after Testosterone Treatment in Boys with Constitutional Delay of Growth and Adolescence: Evidence against an Increase in Hypothalamic Secretion of Growth Hormone-Releasing Hormone
Racine, M. S., Symons, K., Foster, C. M., & Barkan, A. L. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-031948 · Cited by 12
Growth Hormone Supplementation in the Elderly
Nass, R. M., Park, J., & Thorner, M. O. (2007) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/j.ecl.2006.08.004 · Cited by 12
“Several authors have described a reduction in GH secretory parameters from 15 to 70% in men and women over 60 years of age [32, 33].”
Background
Effect of Oral Phosphate and Alendronate on Bone Mineral Density When Given as Adjunctive Therapy to Growth Hormone Replacement in Adult Growth Hormone Deficiency
White, H. D., Ahmad, A. M., Durham, B. H., et al. (2011) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2010-1929 · Cited by 12
“Advancing age is associated with a decline in spontaneous and stimulated GH secretion, and consequently there is an age-related reduction in serum GH and IGF-I concentrations (41, 42).”
Background
Neuroendocrine Mechanism of Puberty
Terasawa, E., & Kurian, J. R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-375097-6.10019-8 · Cited by 15
The Pituitary Gland and Age-Dependent Regulation of Body Composition
van Beek, A. P., Wolffenbuttel, B. H. R., Runge, E., Trainer, P. J., Jönsson, P., & Kołtowska‐Häggström, M. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2506 · Cited by 12
“The KIMS countries (number of participants) for the present study were Argentina (27), Austria (79), Belgium (326), Switzerland (45), Czech Republic (51), Germany (616), Denmark (29), Spain (309), France (61), United Kingdom (672), Greece (49), Hungry (44), Ireland (74), Italy (7), Korea (19), Luxembourg (6), The Neth…”
Background
Growth Hormone (GH) Treatment in Short Normal Children: Absence of Influence of Time of Injection and Resistance to GH Autofeedback*
Chanoine, J., Vanderschueren‐Lodeweyckx, M., Maes, M., Thiry-Counson, G., Craen, M., & Vliet, G. V. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-6-1269 · Cited by 12
Strategies for psychoendocrine studies of puberty
Hays, S. E. (1978) · Psychoneuroendocrinology · doi:10.1016/0306-4530(78)90037-9 · Cited by 12
THE EFFECT OF PUBERTY AND SHORT‐TERM ORAL ADMINISTRATION OF TESTOSTERONE UNDECANOATE ON GH TESTS AND SEX‐STEROID RELATED PLASMA COMPOUNDS IN GH DEFICIENT PATIENTS
Drop, S. L. S., SABBE‐CLAUS, L., & Visser, H. K. A. (1982) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1982.tb00730.x · Cited by 12
Growth Hormone Deficiency in Elderly Patients with Hypothalamo-Pituitary Tumors
Colao, A. A. L., Cerbone, G., Pivonello, R., Klain, M., Aimaretti, G., Faggiano, A., Somma, C. D., Salvatore, M., & Lombardi, G. (1998) · Pituitary · doi:10.1023/a:1009923025853 · Cited by 12
“GH secretion decreases with aging [ 2 ,3], at a rate of 14%/decade from 20 years of age [4,5].”
Background
Diurnal Episodic Pattern of Insulin Secretion in the Dog
Vanhelder, W. P., Sirek, A., SIREK, O. V., Norwich, K. H., Policova, Z., & VanHelder, T. (1980) · Diabetes · doi:10.2337/diab.29.4.326 · Cited by 12
Plasma growth hormone response to insulin-induced hypoglycemia in infantile autism: A pilot study
Deutsch, S. I., Campbell, M., Perry, R., et al. (1986) · Journal of Autism and Developmental Disorders · doi:10.1007/bf01531578 · Cited by 12
Nocturnal Serum Growth Hormone Concentration is not Augmented by Short-Term Testosterone Infusion in Pubertal Boys
Foster, C. M., Hopwood, N. J., Hassing, J. M., Hale, P. M., Mendes, T. M., Kelch, R. P., & Beitins, I. Z. (1989) · Pediatric Research · doi:10.1203/00006450-198910000-00007 · Cited by 11
Effects of Lifelong Dietary Restriction on Somatotropes: Immunohistochemical and Functional Aspects
Shimokawa, I., Higami, Y., Okimoto, T., Tomita, M., & Ikeda, T. (1996) · The Journals of Gerontology Series A · doi:10.1093/gerona/51a.6.b396 · Cited by 12
“T secretion of growth hormone (GH) from the pituitary gland declines with age; the amplitude and duration but not the trough level of GH pulses are reduced in aged animals (Finkelstein et al., 1972; Sonntag et al., 1980).”
Background
The effect of adenotonsillectomy on serum insulin like growth factors and the adenoid/nasopharynx ratio in pediatric patients: A blind, prospective clinical study
Tatlıpınar, A., Atalay, S., Esen, E., Yılmaz, G., Köksal, S., & Gökçeer, T. (2011) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/j.ijporl.2011.11.014 · Cited by 11
“In addition, all these studies were related with effects of ATH or adenotonsillectomy on growth and biochemical markers and anthropometric measurements.”
Influential
Dependency of growth hormone (GH) stimulation following releasing hormones on the spontaneous 24-hour GH secretion in healthy male and female subjects
Voderholzer, U., Laakmann, G., Hinz, A., Daffner, C., Haag, C., Hofmann, H.-P., & Börschel, B. (1993) · Psychoneuroendocrinology · doi:10.1016/0306-4530(93)90012-a · Cited by 11
A Blend of Chlorophytum Borivilianum and Velvet Bean Increases Serum Growth Hormone in Exercise-Trained Men
Alleman, R. J., Canale, R. E., McCarthy, C. G., & Bloomer, R. J. (2011) · Nutrition and Metabolic Insights · doi:10.4137/nmi.s8127 · Cited by 11
Comparing the Behavioural Effects of Exogenous Growth Hormone and Melatonin in Young and Old Wistar Rats
Barceló, P., Nicolau, C., Gamundı́, A., Fiol-deRoque, M. A., Tresguerres, J. A. F., Akaârir, M., & Rial, R. V. (2016) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/5863402 · Cited by 11
“Importantly, the plasmatic levels of GH [6] and Mel [7] show important age-related reductions that have been causally related to the impairments of aging.”
Background
A novel controlled drug-delivery system for growth hormone applied to healing skin wounds in diabetic rats
Gimeno, M. J., García‐Esteo, F., García‐Honduvilla, N., et al. (2003) · Journal of Biomaterials Science Polymer Edition · doi:10.1163/156856203768366549 · Cited by 11
Testosterone Supplementation in Older Men Restrains Insulin-Like Growth Factor’s Dose-Dependent Feedback Inhibition of Pulsatile Growth Hormone Secretion
Veldhuis, J. D., Keenan, D. M., Bailey, J. N., Adeniji, A., Miles, J. M., Paulo, R., Cosma, M., & Soares-Welch, C. V. (2008) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2008-1516 · Cited by 11
INFLUENCE OF AGE, WEIGHT AND GROWTH RATE ON BASAL LH, GROWTH HORMONE AND CORTISOL, AND ESTROGEN-INDUCED LH RELEASE IN PREPUBERTAL GILTS
Kirkwood, R. N., EVANS, F. D., & AHERNE, F. X. (1987) · Canadian Journal of Animal Science · doi:10.4141/cjas87-105 · Cited by 11
Alterations in Hypothalamo-Hypophyseal Function by Ethanol
Wand, G. S., & Froehlich, J. C. (1991) · Neuroendocrine perspectives · doi:10.1007/978-1-4612-3146-2_2 · Cited by 11
Editorial: Pulsatile Hormone Patterns Governing Transcription Factor Function
Schwartz, J. (2001) · Endocrinology · doi:10.1210/endo.142.11.8564 · Cited by 11
“Since it was established that pituitary GH is secreted in a pulsatile pattern (1, 2), the physiological importance of the GH secretion pattern has been sought.”
Background
Effects of Growth Hormone Releasing Peptides on Stimulated Growth Hormone Secretion in Old Rats
Walker, R. F., Yang, S., Masuda, R., et al. (1994) · Springer eBooks · doi:10.1007/978-1-4613-8372-7_13 · Cited by 11
Association of Sleep Duration and Cardio-Ankle Vascular Index in Community-Dwelling Older Adults
Masumitsu, T., Kubozono, T., Miyata, M., Makizako, H., Tabira, T., Takenaka, T., Kawasoe, S., Tokushige, A., Niwa, S., & Ohishi, M. (2022) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.63594 · Cited by 10
A novel stereotaxic approach to the hypothalamus for the use of push-pull perfusion cannula in Holstein calves
Kasuya, E., Sakumoto, R., Saito, T., et al. (2004) · Journal of Neuroscience Methods · doi:10.1016/j.jneumeth.2004.06.006 · Cited by 10
Comparison of growth hormone releasing hormone therapy and growth hormone therapy in growth hormone deficiency
Butenandt, O., & Staudt, B. (1989) · European Journal of Pediatrics · doi:10.1007/bf00595894 · Cited by 10
“secretion is episodic and release occurs predominantly during sleep [1, 8].”
Background
Conflicts with the sornatopause
Toogood, A. A., & Shalet, S. M. (1998) · Growth Hormone & IGF Research · doi:10.1016/s1096-6374(98)80009-9 · Cited by 10
Circadian rhythmicity of prolactin secretion in elderly subjects: changes during bromocriptine treatment
POLLERI, A., Masturzo, P., Murialdo, G., & AGNOLI, A. (1981) · Journal of Endocrinological Investigation · doi:10.1007/bf03349450 · Cited by 10
STUDIES OF HYPOTHALAMIC PITUITARY STRUCTURE AND FUNCTION IN PATIENTS PREVIOUSLY TREATED WITH BILATERAL ADRENALECTOMY ALONE FOR CUSHING'S DISEASE
BEACOM, R., Atkinson, A. B., Kennedy, A., Sheridan, B., Hadden, D. R., Merrett, J. D., & McIlrath, E. M. (1986) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1986.tb01671.x · Cited by 10
Neural Regulation of Pituitary Function
Stuenkel, C. A. (1991) · Epilepsia · doi:10.1111/j.1528-1157.1991.tb05888.x · Cited by 10
Reduction of growth hormone secretion following clomiphene administration
Perlow, M. J., Sassin, J. F., BOYAR, R. M., HELLMAN, L., & Weitzman, E. D. (1973) · Metabolism · doi:10.1016/0026-0495(73)90272-2 · Cited by 10
Self-citation
Neuroendocrine Changes in Affectively Ill Children and Adolescents
Weller, E. B., & Weller, R. A. (1988) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30432-8 · Cited by 10
The Control of Somatotropin Secretion
Müller, E. E. (1979) · Elsevier eBooks · doi:10.1016/b978-0-12-447207-5.50009-4 · Cited by 10
Growth Hormone
Cryer, P. E., & Daughaday, W. H. (1977) · Elsevier eBooks · doi:10.1016/b978-0-12-475360-0.50015-8 · Cited by 10
Immunomodulating Role of Growth Hormone
Fabris, N., & Mocchegiani, E. (1994) · Springer eBooks · doi:10.1007/978-1-4613-8372-7_9 · Cited by 10
Common and Uncommon Mouse Models of Growth Hormone Deficiency
List, E. O., Basu, R., Berryman, D. E., Duran‐Ortiz, S., Martos‐Moreno, G. Á., & Kopchick, J. J. (2024) · Endocrine Reviews · doi:10.1210/endrev/bnae017 · Cited by 10
Light exposure during night suppresses nocturnal increase in growth hormone secretion in Holstein steers1
Kasuya, E., Kushibiki, S., Yayou, K., et al. (2008) · Journal of Animal Science · doi:10.2527/jas.2008-0877 · Cited by 9
ORIGINAL ARTICLE: Associations of the growth hormone receptor (GHR) gene polymorphisms with adiposity and IGF‐I activity in adolescents
Mong, J. L. Y., Ng, M. C. Y., Guldan, G. S., Tam, C. H. T., Lee, H. M., Ronald, C. W., So, W. Y., Wong, G., Kong, A. P. S., Chan, J. C. N., et al. (2010) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2010.03786.x · Cited by 9
Non-insulin-dependent diabetic patients (NIDDMs) do not demonstrate the dawn phenomenon at presentation
Atiea, J., Vora, J. P., Owens, D. R., Luzio, S. D., Read, G. F., Walker, R. F., & Hayes, T. M. (1988) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(88)80076-7 · Cited by 9
Promises and Challenges in Continuous Tracking Utilizing Amino Acids in Skin Secretions for Active Multi‐Factor Biometric Authentication for Cybersecurity
Agudelo, J., Privman, V., & Halámek, J. (2017) · ChemPhysChem · doi:10.1002/cphc.201700044 · Cited by 11
Life extension versus improving quality of life
Nass, R. M., & Thorner, M. O. (2004) · Best Practice & Research Clinical Endocrinology & Metabolism · doi:10.1016/j.beem.2004.02.003 · Cited by 10
Episodic Growth Hormone Secretory Pattern in Male Rats: Relationship to Gonadal Steroid Hormones
Ahmed, H. H., Fayez, M., & Meites, J. (1989) · Zentralblatt für Veterinärmedizin Reihe A · doi:10.1111/j.1439-0442.1989.tb00733.x · Cited by 9
Growth Response to Daily Subcutaneous Administration of Growth Hormone
Kikuchi, K., Sudo, M., Miyarnoto, A., et al. (1988) · Pediatrics International · doi:10.1111/j.1442-200x.1988.tb01580.x · Cited by 9
Episodic GH Secretion: Evidence for a Hypothalamic Dopaminergic Mechanism
Willoughby, J. O., & Martin, J. B. (1976) · Springer eBooks · doi:10.1007/978-1-4684-2598-7_16 · Cited by 9
Lifespan extension in the spontaneous dwarf rat and enhanced resistance to hyperoxia-induced mortality
Sasaki, T., Tahara, S., Shinkai, T., Kuramoto, K., Matsumoto, S., YANABE, M., Takagi, S., Kondo, H., & Kaneko, T. (2013) · Experimental Gerontology · doi:10.1016/j.exger.2013.02.015 · Cited by 8
“, 1985), and the secretion rate of GH in adolescents has been shown to be higher than that in prepubertal children and young adults (Finkelstein et al., 1972).”
Background
Effect of physical training on age-related reduction of GH secretion during exercise in normally cycling women
Coiro, V., Volpi, R., Gramellini, D., Maffei, M. L., Volta, E., Melani, A., & Chiodera, P. (2010) · Maturitas · doi:10.1016/j.maturitas.2009.12.020 · Cited by 8
Circadian Modulation of Endocrine Secretion
Cauter, E. V., & Buxton, O. M. (2001) · Handbook of behavioral neurobiology · doi:10.1007/978-1-4615-1201-1_26 · Cited by 8
Sleep and growth hormone secretion in women athletes
Walsh, B. T., Puig-Antich, J., Goetz, R. R., et al. (1984) · Electroencephalography and Clinical Neurophysiology · doi:10.1016/0013-4694(84)90088-9 · Cited by 8
GROWTH HORMONE DEFICIENCY AND THE MEASUREMENT OF SOMATOMEDIN C/IGF‐I: THE INFLUENCE OF SEXUAL MATURATION
RAYNER, P. H. W., Rudd, B. T., Thomas, P., et al. (1988) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1988.tb03667.x · Cited by 8
Psychobiology of Childhood Depression
Burke, P. M., & Puig-Antich, J. (1990) · Springer eBooks · doi:10.1007/978-1-4615-7142-1_25 · Cited by 8
SLEEP-RELATED HORMONES
Sassin, J. F. (1977) · Elsevier eBooks · doi:10.1016/b978-0-12-222350-1.50026-x · Cited by 8
Polygraphic sleep patterns and growth hormone secretion in children after cranial irradiation
Fagioli, I., Brauner, R., & Rappaport, R. (1991) · European Journal of Pediatrics · doi:10.1007/bf01963567 · Cited by 7
“Prepubertal children remaining in bed throughout the 24 h period secrete GH only during sleep and not while awake [ 12 ].”
Age-Related Decreases in Growth Hormone and Insulin-Like Growth Factor (IGF)–1: Implications for Brain Aging
Sonntag, W. E., Brunso‐Bechtold, J. K., & Riddle, D. R. (2001) · Rejuvenation Research · doi:10.1089/10945450152850641 · Cited by 7
“2,3 Although the precise function of this ultradian pattern remains unknown, the pulsatile nature of GH release has been confirmed in every species examined to date and is necessary for full biologic actions of the hormone.”
Nutritional evaluation in surgical treatment of children with hypertrophic tonsils and or adenoids
Dualibi, A. P. F. F., Pignatari, S. S. N., & Weckx, L. L. M. (2002) · International Journal of Pediatric Otorhinolaryngology · doi:10.1016/s0165-5876(02)00208-2 · Cited by 7
The combined T3/TRH test in depressed patients and healthy controls
Schüle, C., Baghai, T. C., Tsikolata, V., Zwanzger, P., Eser, D., Schaaf, L., & Rupprecht, R. (2004) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2004.10.001 · Cited by 7
A neuroendocrine overview of aging
Frohman, L. A. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90083-3 · Cited by 7
Characterization of Somatostatin Receptor Subtypes in Mammalian Pituitary
Epelbaum, J., Briard, N., Djordjijević, D., et al. (1998) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1998.tb10769.x · Cited by 7
D-factor and growth hormone enhance tumor necrosis factor-induced increase of Mn superoxide dismutase mRNA and oxygen tolerance
Tsan, M., White, J. E., & Wong, G. H. (1992) · Cytokine · doi:10.1016/1043-4666(92)90044-r · Cited by 7
The Effects of Acute and Chronic Growth Hormone (GH) Administration on GH Secretion in Patients with Idiopathic GH Deficiency*
HANEW, F., GOH, M., Sato, S., SHIMIZU, Y., Sasaki, A., Aida, M., & YOSHINAGA, K. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-66-4-715 · Cited by 7
The Endocrinology of Extrapyramidal System Disorders
Kirkpatrick, B. W., & Tamminga, C. A. (1988) · Neurologic Clinics · doi:10.1016/s0733-8619(18)30890-9 · Cited by 7
Role of Monoaminergic Neurons in the Age-Related Alterations in Anterior Pituitary Hormone Secretion
Simpkins, J. W., & Estes, K. S. (1984) · Springer eBooks · doi:10.1007/978-94-011-7674-3_17 · Cited by 7
Effect of aging on growth hormone, ACTH and cortisol response to insulin-induced hypoglycemia in type I diabetes
Muggeo, M., Moghetti, P., Querena, M., et al. (1985) · Acta Diabetologica · doi:10.1007/bf02590790 · Cited by 6
Overnight growth hormone secretion in short children: independence of the sleep pattern
Buzi, F., Zanotti, P., Tiberti, A., Monteleone, M., Lombardi, A., & Ugazio, A. G. (1993) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.77.6.8263132 · Cited by 7
The Ontogeny of Pulsatile Growth Hormone Secretion and Its Temporal Relationship to the Onset of Puberty in the Agonadal Male Rhesus Monkey (Macaca mulatta)
Suter, K. J. (2004) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2003-032034 · Cited by 5
Function of GH/IGF-I axis in aging: Multicenter study in 152 healthy elderly subjects with different degrees of physical activity
Italian Association for Research on Brain Aging (AIRIC) Multicenter Study Group (1997) · Aging Clinical and Experimental Research · doi:10.1007/bf03340148 · Cited by 7
The influence of 4–week treatment with sertraline on the combined T3/TRH test in depressed patients
Schüle, C., Baghai, T. C., Alajbegović, L., Schwarz, M., Zwanzger, P., Eser, D., Schaaf, L., Møller, H. J., & Rupprecht, R. (2005) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-005-0571-0 · Cited by 6
Effects of Human Growth Hormone in Men over 60 Years Old
(1990) · New England Journal of Medicine · doi:10.1056/nejm199011293232212 · Cited by 6
Assessment of physical maturation and somatomedin levels during puberty
Rothenberg, L. H., Hintz, R. L., & VanCamp, M. (1977) · American Journal of Orthodontics · doi:10.1016/0002-9416(77)90282-2 · Cited by 6
Age‐Related Changes in Urinary Growth Hormone Level and Its Clinical Application
Nukada, O., Moriwake, T., Kanzaki, S., et al. (1990) · Pediatrics International · doi:10.1111/j.1442-200x.1990.tb00781.x · Cited by 6
Neuroendocrine Changes in Affectively Ill Children and Adolescents
Weller, E. B., & Weller, R. A. (1988) · Neurologic Clinics · doi:10.1016/s0733-8619(18)30883-1 · Cited by 6
Aging and Hypothalamic Regulation of Metabolic, Autonomic, and Endocrine Function
Almli, C. R. (1984) · Springer eBooks · doi:10.1007/978-1-4613-2705-9_2 · Cited by 6
Les facteurs d’accidents de la route par somnolence chez les conducteurs âgésPrévention par l’activité physiqueSleepiness-related road traffic accidents among elderly drivers: an analysis of the contributory factorsThe preventive role of physical activity
Gruau, S., Pottier, A., Davenne, D., & Denise, P. (2003) · Recherche Transports Sécurité · doi:10.1016/s0761-8980(03)00011-6 · Cited by 7
Relationship between the thyroidal and gonadal axes during the estrous cycle of ewes of different breeds and ages
Peeters, R. P., Buys, N., Pauwels, I., et al. (1989) · annales de biologie animale biochimie biophysique · doi:10.1051/rnd:19890301 · Cited by 5

Authors: FINKELSTEIN, J. W., ROFFWARG, H. P., BOYAR, R. M., KREAM, J., & HELLMAN, L.
Affiliations: Montefiore Medical Center (US)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1972-11
Volume: 35
Issue: 5
Pages: 665-670
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-35-5-665
OpenAlex: W1997993870
Cited by: 640
References: 0
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 5 · 2022: 2 · 2021: 6 · 2020: 2 · 2019: 2 · 2018: 6 · 2017: 7 · 2016: 4 · 2015: 3 · 2014: 4 · 2013: 2 · 2012: 13
FWCI: 7.61
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Pituitary Gland Disorders and Treatments
Keywords: growth hormone secretion, age-related changes, prepubertal children, adolescents, young adults, older adults
MeSH terms: Adolescent, Adult, Age Factors, Child, Circadian Rhythm, Female, Humans, Male, Middle Aged, Secretory Rate, Sleep Stages, Growth Hormone, Time Factors

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

Age-related change in the twenty-four-hour spontaneous secretion of growth hormone

Abstract

Overview

Integrity signals

Verification

Claims the paper makes

Claims other papers make about this one

Citations

Cited by

Related

Metadata

Record

About these checks