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Cited by 55Thyroid Disorders and TreatmentsAdrenal Hormones and DisordersPharmacogenetics and Drug Metabolism

Effects of Phenobarbital on Thyroxine and Triiodothyronine Kinetics in Graves' Disease

CAVALIERI, RALPH R., SUNG, LILLIAN C., BECKER, CHARLES E.·1973·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-37-2-308
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Abstract

Simultaneous measurements of the peripheral kinetics of thyroxine (T4) and triiodothyronine (T3) were made in hyperthyroid patients before and during the administration of phenobarbital (PB). The following alterations in T4 kinetics were noted during PB: Total clearance increased on the average by 18% (p < 0.05). Fecal T4 clearance, calculated from total clearance and the urinary fraction, increased by 103% (p < 0.01). Serum levels of total and free T4 tended to decline during PB, but the changes were variable in magnitude and not proportional to the increments in total clearance. Total T4 pool size and absolute disposal rate were not significantly altered during PB in the group as a whole. As controls, two hypothyroid patients who were being maintained on constant daily doses of T4 were studied. In both, total and fecal T4 clearance increased and serum T4 declined during PB administration. Hepatic T4 distribution volume rose during PB in 2 of the 3 subjects in whom this measurement was made. In 6 of the hyperthyroid patients small decreases occurred during PB in serum T3 concentration, total and fecal clearance, but the changes were not significant. Absolute T3 disposal rate declined by 25% in this group. The findings in regard to T4 metabolism are consistent with the known effect of PB on T4 kinetics in the rat, i.e., an augmentation of T4 clearance primarily via the fecal route secondary to stimulation of hepatic cellular mechanisms of hormone removal. In individuals with a relatively fixed rate of T4 supply, due either to untreated hyperthyroidism or to the administration of a constant replacement dose of T4) the PB-enhanced removal of hormone results in a decline in the level of circulating T4.

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Crossref · 10.1210/jcem-37-2-308

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Authors
CAVALIERI, R. R., SUNG, L. C., & BECKER, C. E.
Affiliations
San Francisco General Hospital (US)
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1973-08
Volume
37
Issue
2
Pages
308-316
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-37-2-308
OpenAlex
W1994996133
Cited by
55
References
0
Citations by year
2026: 2 · 2023: 1 · 2022: 1 · 2021: 1 · 2018: 1 · 2016: 1 · 2015: 1 · 2014: 1
FWCI
2.42
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • Abbott Laboratories
  • National Institutes of Health
  • NIH Clinical Center
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacogenetics and Drug Metabolism
Keywords
phenobarbital, Graves' disease, hyperthyroidism
MeSH terms
Feces, Female, Graves Disease, Humans, Iodine Isotopes, Kinetics, Liver, Male, Phenobarbital, Radioimmunoassay, Thyroxine, Triiodothyronine

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