Metabolism of Testosterone-1,2-3H in Man. Distribution of the Major 17-Ketosteroid Metabolites in Plasma: Relation to Thyroid States
Abstract
Testosterone-1,2-3H was administered by vein to 7 subjects (3 with normal thyroid function, 2 with hyperthyroidism, and 2 hypothyroids) in order to measure the t ½ of testosterone in the circulation, to observe the distribution and disappearance of its principal radioactive conjugated 17-ketosteroid metabolites in the plasma, and to calculate the clearance rates of the individual conjugates. It was found that the t ½ of testosterone ranged from 60–80 min in the hyperthyroids as well as in an euthyroid subject. In all instances, the labeled glucosiduronates were removed from the plasma much more rapidly than were the radioactive sulfates, 65–90% of their maximum plasma radioactivity disappearing within 4 hr. In the sulfate fraction, androsterone sulfate persisted longer than etiocholanolone sulfate; only 13–22% of its maximum plasma radioactivity being removed at this time. These findings are consistent with the clearance rates (ml per min) of the individual conjugates: androsterone sulfate (0.5–4.9), etiocholanolone sulfate (8.8–19.8) and the corresponding glucosiduronates (73–350). Myxedema was associated with a lower proportion of circulating labeled androsterone conjugates, particularly sulfate, as compared with the euthyroid and hyperthyroid states which is in accord with the distribution among the urinary conjugates.
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Clearance of steroid glucuronides generally proceeds faster than clearance of steroid sulfates, presumably due to the irreversible nature of glucuronidation in humans.
“The clearance of steroid glucuronides generally proceeds faster than the clearance of steroid sulfates [195], presumably due to the irreversible nature of glucuronidation in humans.”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [195]
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- Authors
- HELLMAN, L., & ROSENFELD, R. S.
- Affiliations
- Montefiore Medical Center (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1974-03
- Volume
- 38
- Issue
- 3
- Pages
- 424-435
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2033595545
- Cited by
- 21
- References
- 0
- Citations by year
- 2025: 1 · 2020: 1 · 2019: 1 · 2015: 1
- FWCI
- 2.42
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Cancer Institute
- NIH Clinical Center
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- testosterone metabolism, androsterone sulfate, glucuronide conjugates, plasma clearance, half-life, hyperthyroidism, hypothyroidism, myxedema, thyroid function
- MeSH terms
- Adolescent, Adult, Aged, Androsterone, Carbon Radioisotopes, Chromatography, Etiocholanolone, Female, Glucuronates, Half-Life, Humans, Hyperthyroidism, Hypothyroidism, Male, Middle Aged, Radioisotope Dilution Technique, Sulfates, Testosterone, Time Factors, Tritium, 17-Ketosteroids
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