The excretion of metabolites of testosterone and of estradiol in male patients with chronic renal failure
Open accessAbstract
Intravenous infusions of 14C-testosterone (Te) either alone or in combination with 3H-estradiol (E2) were given to five normal male subjects, twelve male patients on haemodialysis (HD) treatment and to one patient with a very restricted renal function. The elimination of radioactivity was measured in urine, HD fluid and faeces. Urinary excretion diminished with renal function. It was negligible at a creatinine clearance of less than one ml per minute. A quarter of both isotopes was eliminated by six HD treatments within three weeks. No difference was found in this respect between nephrectomized patients and those who were still in possession of their kidneys. The main excretion occurred in the stools. E2 metabolites, and to a lesser extent Te metabolites, appeared in the faeces within 24 hours, which might be explained by biliary excretion only. More 3H (E2 metabolites) than 14C (Te metabolites) was found in the faeces; more 14C than 3H found in HD fluid.
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Estrogens seem to undergo higher biliary excretion than other steroids, but also higher reabsorption leading to low fecal excretion.
“estrogens seem to undergo higher biliary excretion than other steroids, but also higher reabsorption leading to low fecal excretion [194,206].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [194]
Steroids are excreted predominantly as their conjugates in urine and bile, with urine excretion accounting for approximately 80% of excretion following exogenous administration.
“Steroids are excreted predominantly as their conjugates in the urine and bile, with urine excretion accounting for approximately 80% of excretion following exogenous administration [194].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [194]
Cites
Sandberg, A. A., & Slaunwhite, W. R. (1957) · Journal of Clinical Investigation · doi:10.1172/jci103524 · Cited by 184 · see citing works
LIPOPROTEINS IN PRIMARY BILIARY CIRRHOSIS 1
Russ, E. M., Raymunt, J., & Barr, D. P. (1956) · Journal of Clinical Investigation · doi:10.1172/jci103257 · Cited by 131 · see citing works
METABOLISM OF 4-C14-TESTOSTERONE IN HUMAN SUBJECTS. I. DISTRIBUTION IN BILE, BLOOD, FECES AND URINE
Sandberg, A. A., & Slaunwhite, W. R. (1956) · Journal of Clinical Investigation · doi:10.1172/jci103389 · Cited by 90 · see citing works
Binding of Estrone Sulfate in Human Plasma
Rosenthal, H. E., Pietrzak, E., Slaunwhite, W. R., et al. (1972) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-34-5-805 · Cited by 60 · see citing works
THE ROLE OF THE LIVER AND KIDNEYS IN THE METABOLISM OF INTRAVENOUS TESTOSTERONE BY HUMAN SUBJECTS*†
West, C. D., Tyler, F. H., Brown, H., et al. (1951) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-11-9-897 · Cited by 57 · see citing works
Studies on phenolic steroids in human subjects
Inoue, N., Sandberg, A. A., Graham, J. B., et al. (1969) · Journal of Clinical Investigation · doi:10.1172/jci105995 · Cited by 29 · see citing works
Deery, D. J., & JONES, A. C. (1975) · Journal of Endocrinology · doi:10.1677/joe.0.0640049 · Cited by 29 · see citing works
HELLMAN, L., & ROSENFELD, R. S. (1974) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-38-3-424 · Cited by 21 · see citing works
High-Dose Urography in Oliguric and Anuric Patients.
Martel, W. (1974) · Archives of Internal Medicine · doi:10.1001/archinte.1974.00320130164031 · Cited by 15 · see citing works
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Schiffer, L., Barnard, L., Baranowski, E. S., Gilligan, L. C., Taylor, A. E., Arlt, W., Shackleton, C. H. L., & Storbeck, K.-H. (2019) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/j.jsbmb.2019.105439 · Cited by 450 · see citing works
“other steroids, but also higher reabsorption leading to low fecal excretion [194,206].”
- Authors
- van Kammen, E., Thijssen, J. H. H., Donker, G. H., & Schwarz, F.
- Affiliations
- University Medical Center Utrecht (NL)
- Venue
- Steroids
- Publisher
- Elsevier BV
- Published
- 1975-10
- Volume
- 26
- Issue
- 4
- Pages
- 508-515
- ISSN
- 0039-128X (ISSN-L)
- OpenAlex
- W1995062882
- Cited by
- 12
- References
- 9
- Citations by year
- 2019: 1
- FWCI
- 0.74
- Type
- journal article
- Language
- en
- Open access
- green
- dspace.library.uu.nl
- Licence
- Locations
- Steroids (publishedVersion)
- PubMed (publishedVersion)
- Utrecht University Repository (Utrecht University) (submittedVersion, other-oa)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Steroid Chemistry and Biochemistry
- Keywords
- testosterone metabolites, estradiol metabolites, chronic kidney disease, hemodialysis, urinary excretion, fecal excretion, biliary excretion, creatinine clearance, nephrectomy
- MeSH terms
- Adult, Creatinine, Estradiol, Feces, Renal Dialysis, Humans, Kidney, Kidney Failure, Chronic, Male, Middle Aged, Nephrectomy, Testosterone
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