Cited by 515Ovarian function and disordersEstrogen and related hormone effectsMenopause: Health Impacts and Treatments

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Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood.

JUDD, HOWARD L., JUDD, GEORGE E., LUCAS, WILLIAM E., YEN, SAMUEL S. C.·1974·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-39-6-1020

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Abstract

The concentrations of testosterone, androstenedione, 17β-estradiol, and estrone were measured in peripheral and ovarian vein sera obtained at the time of surgery from 10 postmenopausal women undergoing bilateral oophorectomy. A higher ovarian than peripheral vein concentration was found for all hormones studied. The differences between ovarian and peripheral vein concentrations were 15-fold for testosterone (3033 ± 1046 pg/ml vs 198 ± 27 pg/ml, p <0.01); 4-fold for androstenedione (3455 ± 1330 pg/ml vs 754 ± 174 pg/ml, NS) and 2-fold for both 17β-estradiol (31.1 ± 6.3 pg/ml vs 14.6 ± 2.9 pg/ml, p < 0.05); and estrone (71.5 ± 13.3 pg/ml vs 30.3 ± 3.4 pg/ml, p < 0.05). It is concluded that the postmenopausal ovary continues to secrete a large amount of testosterone and a moderate amount of androstenedione. The small magnitude of the peripheral and ovarian vein estrogen differences could account for only minimal ovarian estrogen secretion.

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Background
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Authors: JUDD, H. L., JUDD, G. E., LUCAS, W. E., & YEN, S. S. C.
Affiliations: University of California San Diego (US)
University of California, Los Angeles (US)
ORCID: LUCAS, WILLIAM E.
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1974-12
Volume: 39
Issue: 6
Pages: 1020-1024
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-39-6-1020
OpenAlex: W2037753918
Cited by: 511
References: 0
Citations by year: 2026: 4 · 2025: 5 · 2024: 2 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 11 · 2016: 10 · 2015: 2 · 2014: 20 · 2013: 10 · 2012: 9
FWCI: 12.93
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
Keywords: postmenopausal ovary, ovarian hormone secretion, testosterone, androstenedione, estradiol, estrone, peripheral venous blood, oophorectomy, ovarian androgen production, estrogen synthesis
MeSH terms: Adult, Aged, Androstenedione, Arm, Estradiol, Estrone, Female, Follicle Stimulating Hormone, Humans, Hysterectomy, Luteinizing Hormone, Menopause, Middle Aged, Ovary, Radioimmunoassay, Testosterone, Veins

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Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood.

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