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Endocrine function of the postmenopausal ovary: concentration of androgens and estrogens in ovarian and peripheral vein blood.
Abstract
The concentrations of testosterone, androstenedione, 17β-estradiol, and estrone were measured in peripheral and ovarian vein sera obtained at the time of surgery from 10 postmenopausal women undergoing bilateral oophorectomy. A higher ovarian than peripheral vein concentration was found for all hormones studied. The differences between ovarian and peripheral vein concentrations were 15-fold for testosterone (3033 ± 1046 pg/ml vs 198 ± 27 pg/ml, p <0.01); 4-fold for androstenedione (3455 ± 1330 pg/ml vs 754 ± 174 pg/ml, NS) and 2-fold for both 17β-estradiol (31.1 ± 6.3 pg/ml vs 14.6 ± 2.9 pg/ml, p < 0.05); and estrone (71.5 ± 13.3 pg/ml vs 30.3 ± 3.4 pg/ml, p < 0.05). It is concluded that the postmenopausal ovary continues to secrete a large amount of testosterone and a moderate amount of androstenedione. The small magnitude of the peripheral and ovarian vein estrogen differences could account for only minimal ovarian estrogen secretion.
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“In fact, the postmenopausal ovary is well known to secrete testosterone, and most authors agree that it also secretes some 4-dione (147, 148).”
From Endocrine and intracrine sources of androgens in women: inhibition of breast cancer and other roles of androgens and their precursor dehydroepiandrosterone (2003) · cites this paper as [147]
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Controversies Regarding Transdermal Androgen Therapy in Postmenopausal Women
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“Indeed, the concentration of testosterone and androstenedione in ovarian veins of postmenopausal women is 15and 4-fold higher, respectively, compared with peripheral vein concentration (18), and oophorectomy results in a significant decrease in these steroids (19).”
BackgroundRepeated serum and urinary androgen measurements in premenopausal and postmenopausal women
Micheli, A., Muti, P. C., Pisani, P., Secreto, G., Recchione, C., Totis, A., Fissi, R., Cavalleri, A., Panico, S., & Berrino, F. (1991) · Journal of Clinical Epidemiology · doi:10.1016/0895-4356(91)90007-v · Cited by 37
EFFECT OF AGE ON PLASMA ANDROSTENEDIONE CONCENTRATION IN OOPHORECTOMIZED WOMEN
CRILLY, R. G., MARSHALL, D. H., & NORDIN, B. E. C. (1979) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1979.tb01367.x · Cited by 37
“…of the menopause on the plasma androstenedione level, and the continuing secretion of androstenedione by the stroma of the post-menopausal ovary (Judd et al., 1974), we decided to look at plasma androstenedione as a function of age in oophorectomized women where the ovarian contribution can be…”
BackgroundCasson, P. R., Toth, M. J., Johnson, J. V., Stanczyk, F. Z., Casey, C. L., & Dixon, M. E. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-2390 · Cited by 36
Metadata
- Authors
- JUDD, H. L., JUDD, G. E., LUCAS, W. E., & YEN, S. S. C.
- Affiliations
- University of California San Diego (US)
- University of California, Los Angeles (US)
- ORCID
- LUCAS, WILLIAM E.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1974-12
- Volume
- 39
- Issue
- 6
- Pages
- 1020-1024
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2037753918
- Cited by
- 511
- References
- 0
- Citations by year
- 2026: 4 · 2025: 5 · 2024: 2 · 2023: 9 · 2022: 6 · 2021: 10 · 2020: 3 · 2019: 8 · 2018: 6 · 2017: 11 · 2016: 10 · 2015: 2 · 2014: 20 · 2013: 10 · 2012: 9
- FWCI
- 12.93
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Endocrinology › Estrogen and related hormone effects
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Menopause: Health Impacts and Treatments
- Keywords
- postmenopausal ovary, ovarian hormone secretion, testosterone, androstenedione, estradiol, estrone, peripheral venous blood, oophorectomy, ovarian androgen production, estrogen synthesis
- MeSH terms
- Adult, Aged, Androstenedione, Arm, Estradiol, Estrone, Female, Follicle Stimulating Hormone, Humans, Hysterectomy, Luteinizing Hormone, Menopause, Middle Aged, Ovary, Radioimmunoassay, Testosterone, Veins
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