Inhibin A and B in adolescents and young adults with Turner's syndrome and no sign of spontaneous puberty
Abstract
BACKGROUND: The aim of this study was to assess levels of inhibin A and B, FSH and LH in Turner's syndrome (TS) without signs of spontaneous ovarian activity. METHODS: Twenty-four girls with TS (median age, 14.7 years) without signs of spontaneous ovarian function were included in the study. Sixty prepubertal girls (PPG) (10.3 years) that had not yet experienced menarche (all Tanner stage 1), and 34 pubertal girls (PG) (13.8 years) (Tanner stage 3-4), who were regularly menstruating, served as controls. The levels of inhibin A and B, FSH, LH, and pubertal stage were determined. RESULTS: Inhibin A was not detected in females with TS, or in almost all PPG (59 of 60) (P = not significant), and inhibin B in TS females, while most PPG produced inhibin B (53 of 60, P < 0.0005). FSH and LH were elevated in TS, but with overlapping values. In follow-up samples in TS, three of twenty-four females showed detectable levels of inhibin A and/or B. In one of these, 6 serial samples were available. At 20 years this patient had a high level of LH and FSH, which declined, and concurrently inhibin A and inhibin B rose, only later to decrease, when FSH and LH started to rise again. In comparison with PG baseline levels of inhibin A and B were lower in TS, with inhibin A detectable in 23 of 34, and inhibin B detectable in 32 of 34 PG. Levels of FSH and LH were also different, although with overlapping values. CONCLUSION: The result raises the possibility that functional or partly functional ovaries are present in some females with TS, without apparent menstrual cycling.
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Low AMH and undetectable inhibin B can be used to predict ovarian insufficiency in Turner syndrome.
“Low AMH and undetectable inhibin B can also be used to predict ovarian insufficiency in TS”
From Clinical practice guidelines for the care of girls and women with Turner syndrome. (2024) · cites this paper as [269]
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- Authors
- Gravholt, C. H.
- Affiliations
- Aarhus Municipality (DK)
- Corresponding author
- Gravholt, C. H.
- ORCID
- Gravholt, C. H.
- Venue
- Human Reproduction
- Publisher
- Oxford University Press (OUP)
- Published
- 2002-08-01
- Volume
- 17
- Issue
- 8
- Pages
- 2049-2053
- ISSN
- 0268-1161 (ISSN-L)
- 1460-2350
- OpenAlex
- W2070324435
- Cited by
- 42
- References
- 17
- Citations by year
- 2024: 3 · 2023: 2 · 2022: 6 · 2021: 2 · 2020: 3 · 2019: 4 · 2018: 2 · 2017: 4 · 2014: 1 · 2013: 4 · 2012: 1
- FWCI
- 0.35
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Human Reproduction (publishedVersion)
- PubMed (publishedVersion)
- Funders
- European Society for Paediatric Endocrinology
- European Society of Endocrinology
- Novo Nordisk
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Genetics › Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Sexual Differentiation and Disorders
- Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
- Keywords
- Turner syndrome, inhibin A, inhibin B, follicle-stimulating hormone, luteinizing hormone, ovarian function, ovarian reserve, prepubertal girls, pubertal girls
- MeSH terms
- Adolescent, Adult, Child, Female, Follicle Stimulating Hormone, Humans, Inhibins, Luteinizing Hormone, Menarche, Puberty, Turner Syndrome
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