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Cited by 74Pancreatic function and diabetesDiabetes Management and ResearchDiabetes Treatment and Management

Glucagon Metabolism in Man. Studies on the Metabolic Clearance Rate and the Plasma Acute Disappearance Time of Glucagon in Normal and Diabetic Subjects

ALFORD, FRANK P., BLOOM, S. R., NABARRo, J. D. N.·1976·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-42-5-830
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Abstract

To investigate further the "hyperglucagonaemia" of diabetes mellitus, the metabolic clearance rate (MCR) and acute disappearance time (t1/2) of unlabelled pancreatic glucagon were estimated in 9 normal subjects and 7 insulin-dependent diabetics, using a constant infusion technique. The mean MCR (+/-SE) was similar for both groups (control: 9.0 +/- 0.6; diabetics: 11.4 +/- 1.0 ml/kg/min). The MCR was not influenced by the concentration of glucagon at the time of plateau, and the exogenous hormone appeared to be handled similarly to endogenous glucagon. On the other hand, t1/2 calculated from the fractional decay rate of glucagon from plateau was significantly prolonged in the diabetics (t1/2 6.6 +/- 0.5 min) compared with the control group (t1/2 4.8 +/- 0.2 min, P less than 0.01). Furthermore, there was no correlation between MCR and t1/2, for the control, diabetic, or combined group. It therefore appears that the MCR of glucagon is similar in normal and diabetic subjects. However, since the acute disappearance time (t1/2) of glucagon is not identical in these two groups, it appears that the kinetics of the overall in vivo metabolism of pancreatic glucagon are not similar in diabetic and control subjects.

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Crossref · 10.1210/jcem-42-5-830

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  • The optimal parameters reside in the physiological range compared with reported half-life values of 3-6 min and 6.6±0.5 min.

    “Compared with the reported information from the pharmaceutical company (3–6 min)20 and the literature (6.6±0.5 min),21 the optimal parameters reside in the physiological range.”

    From Pharmacokinetics Modeling of Exogenous Glucagon in Type 1 Diabetes Mellitus Patients (2013) · cites this paper as [21]

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Related

Authors
ALFORD, F. P., BLOOM, S. R., & NABARRo, J. D. N.
ORCID
BLOOM, S. R.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1976-05
Volume
42
Issue
5
Pages
830-838
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-42-5-830
OpenAlex
W2044346387
Cited by
74
References
30
Citations by year
2026: 1 · 2025: 4 · 2024: 1 · 2023: 1 · 2022: 3 · 2021: 1 · 2019: 1 · 2018: 2 · 2017: 3 · 2016: 2 · 2015: 1 · 2014: 1 · 2013: 4 · 2012: 2
FWCI
8.14
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
Keywords
metabolic clearance rate, hyperglucagonaemia, diabetes mellitus, type 1 diabetes, pancreatic glucagon
MeSH terms
Adolescent, Adult, Clinical Trials as Topic, Diabetes Mellitus, Female, Glucagon, Humans, Male, Metabolic Clearance Rate, Middle Aged

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