ABNORMALITIES OF GLUCAGON METABOLISM IN UNTREATED DIABETES MELLITUS
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A similar regulation of human alpha-cells may explain why diabetic patients with hyperglycemia display paradoxical hyperglucagonemia and why a further glucose challenge has been found to stimulate glucagon release.
“A similar regulation of human ␣-cells may explain why diabetic patients with hyperglycemia display paradoxical hyperglucagonemia and why a further glucose challenge has been found to stimulate glucagon release (9 -11).”
From Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations (2006) · cites this paper as [9]
Cites
Studies of pancreatic alpha cell function in normal and diabetic subjects
Unger, R. H., Aguilar-Parada, E., Müller, W. A., & Eisentraut, A. M. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106297 · Cited by 837 · see citing works
Radioimmunological determination of pancreatic and gut glucagon in plasma
Hedïng, L. G. (1971) · Diabetologia · doi:10.1007/bf02346248 · Cited by 394 · see citing works
The effect of experimental insulin deficiency on glucagon secretion
Müller, W. A., Faloona, G. R., & Unger, R. H. (1971) · Journal of Clinical Investigation · doi:10.1172/jci106691 · Cited by 240 · see citing works
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The essential role of glucagon in the pathogenesis of diabetes mellitus
Unger, R., & Orci, L. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92375-2 · Cited by 599 · see citing works
Regulation of Pancreatic Insulin and Glucagon Secretion
Gerich, J. E., Charles, M. A., & Grodsky, G. M. (1976) · Annual Review of Physiology · doi:10.1146/annurev.ph.38.030176.002033 · Cited by 332 · see citing works
Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells
Vieira, E., Salehi, A., & Gylfe, E. (2007) · Diabetologia · doi:10.1007/s00125-006-0511-1 · Cited by 218 · see citing works
Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations
Salehi, A., Vieira, E., & Gylfe, E. (2006) · Diabetes · doi:10.2337/db06-0080 · Cited by 159 · see citing works
ALFORD, F. P., BLOOM, S. R., & NABARRo, J. D. N. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-42-5-830 · Cited by 74 · see citing works
Compartmental modeling of glucagon kinetics in the conscious dog
Dobbins, R. L., Davis, S. N., Neal, D. W., Cobelli, C., Jaspan, J., & Cherrington, A. D. (1995) · Metabolism · doi:10.1016/0026-0495(95)90051-9 · Cited by 72 · see citing works
- Authors
- Buchanan, K. D., & Mccarroll, A. M.
- Affiliations
- Queen's University Belfast (GB)
- Venue
- The Lancet
- Publisher
- Elsevier BV
- Published
- 1972-12
- Volume
- 300
- Issue
- 7792
- Pages
- 1394-1395
- ISSN
- 0099-5355 (ISSN-L)
- 0140-6736
- OpenAlex
- W2023669319
- Cited by
- 97
- References
- 3
- Citations by year
- 2026: 1 · 2024: 1 · 2018: 2
- FWCI
- 13.81
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Lancet (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Surgery › Pancreatic function and diabetes
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Treatment and Management
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Diabetes Management and Research
- Keywords
- glucagon, diabetes mellitus, untreated diabetes, oral glucose tolerance test, insulin deficiency, pancreatic hormone secretion
- MeSH terms
- Adult, Aged, Blood Glucose, Diabetes Mellitus, Fasting, Female, Glucagon, Glucose Tolerance Test, Humans, Insulin, Male, Middle Aged, Time Factors
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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