The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
The Simultaneous Radioimmunoassay of Seven Steroids in Human Spermatic and Peripheral Venous Blood
Abstract
Seven unconjugated neutral steroids, including testosterone and some of its precursors and metabolites, were measured in the peripheral and spermatic venous blood males, employing specific radioimmunoassays after the fractionation of steroids on Lipidex-5000 (hydroxyalkoxypropyl Sephadex) microcolumns. Respective mean concentrations (ng/ml) and ranges of steroids estimated in peripheral and spermatic venous blood in all groups of patients were as follows: pregnenolone, 0.71 (0.29-2.39) and 10.97 (0.83-30.1); progesterone, 0.31 (0.02-0.57) and 10.17 (1.51-33.24); 17 alpha-hydroxyprogesterone, 1.04 (0.48-2.20) and 37.33 (1.68-141.00); androstenedione, 1.01 (0.26-2.65) and 11.87 (0.97-30.18); testosterone, 3.84 (0.63-10.64) and 255.1 (2.85-619.1); 5alpha-dihydrotestosterone, 0.19 (0.07-0.28) and 3.74 (0.04-9.71); androsterone, 0.27 (0.12-0.47) and 0.97 (0.20-2.15). Concentrations are similar to those estimated by mass spectrometry and protein binding assays, except for androsterone which has not previously been measured in this context. The low, but significant testicular secretion of both 5alpha-hydrotestosterone and androsterone suggests that these two steroids are testicular androgen metabolites, and that androgen metabolism in this tissue may be monitored by way of their measurement in spermatic vein blood.
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In the citing paper
“Testicular steroid output is predominantly testosterone, with lower levels of A4 and DHEA also being released into circulation [[51], [52], [53]].”
From Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: a comprehensive review (2019) · cites this paper as [52]
In the citing paper
“Concentrations of androgen in testicular venous blood of healthy individuals are T (high nanomolar-low micromolar) » A4, DHEA (medium nanomolar) (Hammond et al., 1977, Ishida et al., 1990, Weinstein et al., 1974).”
From Intracrine androgen biosynthesis, metabolism and action revisited (2018) · cites this paper as Hammond et al., 1977
Citations
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Metadata
- Authors
- HAMMOND, G. L., RUOKONEN, A., KONTTURI, M., KOSKELA, E., & VIHKO, R.
- Affiliations
- University of Oulu (FI)
- ORCID
- HAMMOND, G. L.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1977-07
- Volume
- 45
- Issue
- 1
- Pages
- 16-24
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2162613596
- Cited by
- 138
- References
- 23
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2021: 1 · 2020: 1 · 2019: 2 · 2017: 6 · 2016: 1 · 2015: 1 · 2014: 2 · 2013: 1 · 2012: 2
- FWCI
- 8.15
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
- Keywords
- steroid hormones, peripheral venous blood, testosterone, dihydrotestosterone, androsterone, androstenedione, 17-hydroxyprogesterone, pregnenolone, progesterone
- MeSH terms
- Adult, Aged, Androstenedione, Androsterone, Hormones, Humans, Male, Middle Aged, Pregnenolone, Progesterone, Prostatic Neoplasms, Radioimmunoassay, Dihydrotestosterone, Steroids, Testis, Testosterone
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