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Cited by 49Hypothalamic control of reproductive hormonesOvarian function and disordersReproductive Biology and Fertility

The Mechanism of Ovulation Inhibition by Triamcinolone Acetonide*

CUNNINGHAM, GLENN R., GOLDZIEHER, JOSEPH W., DE LA PENA, ARMANDO, OLIVER, MARYELLEN·1978·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-46-1-8
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Abstract

A single dose of 25 mg triamcinolone acetonide, when given on day 1 or 2 of the menstrual cycle, inhibits ovulation. To examine the mechanism of this action, daily determinations of plasm FSH, LH, estrone plus estradiol (E1 + E2), and progestins were performed. Some subjects also received a single dose of LH-RH or hCG on cycle day 15 or clomiphene citrate on days 5-9. Triamcinolone acetonide itself caused variable suppression of plasma estrogens, loss of the mid-cycle gonadotropin surge, and a deficient or absent rise in plasma progestins. Impaired secretion of estrogen did not seem to be due to low gonadotropin levels. FSH and LH responses to LH-RH were adequate in relation to prevailing estrogen levels. Four of six women treated with clomiphene responded with plasma progestin levels which exceed 8 ng/ml. Triamcinolone acetonide seems to affect the hypothalamic-pituitary-ovarian axis mainly by hypothalamic suppression and possibly by a direct effect on the ovary as well.

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Crossref · 10.1210/jcem-46-1-8

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  • The study design did not involve randomization because of concerns about possible carryover effects of glucocorticoids into the subsequent menstrual cycle.

    “Because of concerns about possible carryover effects of glucocorticoids into the subsequent menstrual cycle [36,37], our study design did not involve randomization”

    From Suppression of the Hypothalamic-Pituitary-Ovarian Axis in Normal Women by Glucocorticoids1 (1993) · cites this paper as [37]

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Authors
CUNNINGHAM, G. R., GOLDZIEHER, J. W., DE LA PENA, A., & OLIVER, M.
Affiliations
Texas Biomedical Research Institute (US)
ORCID
CUNNINGHAM, GLENN R.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1978-01
Volume
46
Issue
1
Pages
8-14
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-46-1-8
OpenAlex
W2005126283
Cited by
49
References
1
Citations by year
2022: 2 · 2017: 1 · 2016: 2 · 2015: 1 · 2013: 1 · 2012: 1
FWCI
3.00
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
  • Health Sciences › Medicine › Reproductive Medicine › Ovarian function and disorders
  • Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords
triamcinolone acetonide, ovulation inhibition, hypothalamic-pituitary-ovarian axis, gonadotropin suppression, follicle-stimulating hormone, luteinizing hormone, estradiol, estrone, LH-RH stimulation, clomiphene citrate
MeSH terms
Adult, Clomiphene, Estrogens, Female, Follicle Stimulating Hormone, Chorionic Gonadotropin, Humans, Luteinizing Hormone, Gonadotropin-Releasing Hormone, Menstruation, Ovulation, Progestins, Triamcinolone Acetonide

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