Abnormal Response of Pancreatic Glucagon to Glycemic Changes in Diabetes Mellitus

Lack of Glucagon Response to Hypoglycemia in Diabetes: Evidence for an Intrinsic Pancreatic Alpha Cell Defect

Gerich, J. E., Langlois, M., Noacco, C., Karam, J. H., & Forsham, P. H. (1973) · Science · doi:10.1126/science.182.4108.171 · Cited by 688 · see citing works

Pancreatic Glucagon Secretion in Normal and Diabetic Subjects

Aguilar-Parada, E., Eisentraut, A. M., & Unger, R. H. (1969) · The American Journal of the Medical Sciences · doi:10.1097/00000441-196906000-00008 · Cited by 538 · see citing works

Functional subdivision of islets of Langerhans and possible role of D cells.

Orci, L., & Unger, R. H. (1975) · The Lancet · doi:10.1016/s0140-6736(75)92078-4 · Cited by 442 · see citing works

Increased “Glucagon Immunoreactivity” in Plasma of Totally Depancreatized Dogs

Vranić, M., Pek, S., & Kawamori, R. (1974) · Diabetes · doi:10.2337/diab.23.11.905 · Cited by 145 · see citing works

Plasma Glucose, Insulin, Pancreatic, and Enteroglucagon Levels in Normal and Depancreatized Dogs

Matsuyama, T., & Foà, P. P. (1974) · Experimental Biology and Medicine · doi:10.3181/00379727-147-38288 · Cited by 107 · see citing works

Interrelationships Between α and β Anomers of Glucose Affecting both Insulin and Glucagon Secretion in the Perfused Rat Pancreas. II.

Grodsky, G. M., Fanska, R. E., & Lundquist, I. (1975) · Endocrinology · doi:10.1210/endo-97-3-573 · Cited by 49 · see citing works

Differential Effects of Alpha- and Beta-D-Glucose on Insulin and Glucagon Secretion from the Isolated Perfused Rat Pancreas

Matschinsky, F. M., Pagliara, A. S., Hover, B., Raymond, M. W., & Stillings, S. N. (1975) · Diabetes · doi:10.2337/diab.24.4.369 · Cited by 41 · see citing works

Extraction of Plasma Insulin in Radioimmunoassay for Removal of Nonspecific Inhibitor and of Circulating Insulin Antibody

Ohneda, A., Toyota, T., Sato, S., & Yamagata, S. (1970) · The Tohoku Journal of Experimental Medicine · doi:10.1620/tjem.100.75 · Cited by 15 · see citing works

The role of α-cell dysregulation in fasting and postprandial hyperglycemia in type 2 diabetes and therapeutic implications

Dunning, B. E., & Gerich, J. E. (2007) · Endocrine Reviews · doi:10.1210/er.2006-0026 · Cited by 369 · see citing works

Alpha cell function in health and disease: influence of glucagon-like peptide-1

Dunning, B. E., Foley, J. E., & Åhrén, B. (2005) · Diabetologia · doi:10.1007/s00125-005-1878-0 · Cited by 268 · see citing works

Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells

Vieira, E., Salehi, A., & Gylfe, E. (2007) · Diabetologia · doi:10.1007/s00125-006-0511-1 · Cited by 218 · see citing works

Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity

Knop, F. K., Aaboe, K., Vilsbøll, T., Vølund, A., Holst, J. J., Krarup, T., & Madsbad, S. (2011) · Diabetes Obesity and Metabolism · doi:10.1111/j.1463-1326.2011.01549.x · Cited by 194 · see citing works

An integrated mathematical model of the dynamics of blood glucose and its hormonal control

Cobelli, C., Federspil, G., Pacini, G., Salvan, A., & Scandellari, C. (1982) · Mathematical Biosciences · doi:10.1016/0025-5564(82)90050-5 · Cited by 182 · see citing works

The separate and combined impact of the intestinal hormones, GIP, GLP-1, and GLP-2, on glucagon secretion in type 2 diabetes

Lund, A., Vilsbøll, T., Bagger, J. I., Holst, J. J., & Knop, F. K. (2011) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00665.2010 · Cited by 169 · see citing works

Metabolism and growth adaptation to environmental conditions in Drosophila

Koyama, T., Texada, M. J., Halberg, K. A., & Rewitz, K. (2020) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-020-03547-2 · Cited by 152 · see citing works

Paradoxical Stimulation of Glucagon Secretion by High Glucose Concentrations

Salehi, A., Vieira, E., & Gylfe, E. (2006) · Diabetes · doi:10.2337/db06-0080 · Cited by 159 · see citing works

Clinical Pharmacokinetics and Pharmacodynamics of Vildagliptin

He, Y. (2012) · Clinical Pharmacokinetics · doi:10.2165/11598080-000000000-00000 · Cited by 128 · see citing works

Pharmacokinetics and Pharmacodynamics of Vildagliptin??in??Patients?? with Type??2??Diabetes??Mellitus

He, Y., Serra, D. B., Wang, Y., Campestrini, J., Rivière, G., Deacon, C. F., Holst, J. J., Schwartz, S. L., Nielsen, J. C., & Ligueros‐Saylan, M. (2007) · Clinical Pharmacokinetics · doi:10.2165/00003088-200746070-00003 · Cited by 103 · see citing works

Function and expression of somatostatin receptors of the endocrine pancreas

Strowski, M. Z., & Blake, A. D. (2008) · Molecular and Cellular Endocrinology · doi:10.1016/j.mce.2008.02.007 · Cited by 101 · see citing works

Metabolic effects of glucagon in humans

Adeva-Andany, M. M., Funcasta-Calderón, R., Fernández-Fernández, C., Castro-Quintela, E., & Carneiro-Freire, N. (2019) · Journal of Clinical & Translational Endocrinology · doi:10.1016/j.jcte.2018.12.005 · Cited by 94 · see citing works

Diabetic and nondiabetic patients with nonalcoholic fatty liver disease have an impaired incretin effect and fasting hyperglucagonaemia

Junker, A. E., Gluud, L. L., Holst, J. J., Knop, F. K., & Vilsbøll, T. (2016) · Journal of Internal Medicine · doi:10.1111/joim.12462 · Cited by 86 · see citing works

X-Box Binding Protein 1 Is Essential for Insulin Regulation of Pancreatic α-Cell Function

Akiyama, M., Liew, C. W., Lu, S., Hu, J. Y., Martinez, R., Hambro, B., Kennedy, R. T., & Kulkarni, R. (2013) · Diabetes · doi:10.2337/db12-1747 · Cited by 79 · see citing works

Glucagon receptor antagonism improves islet function in mice with insulin resistance induced by a high-fat diet

Winzell, M. S., Brand, C. L., Wierup, N., Sidelmann, U. G., Sundler, F., Nishimura, E., & Åhrén, B. (2007) · Diabetologia · doi:10.1007/s00125-007-0675-3 · Cited by 68 · see citing works

Paradoxical Inhibition of Insulin Secretion by Glucose in Human Diabetes Mellitus*

Metz, S. A., Halter, J. B., & Robertson, R. P. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-5-827 · Cited by 59 · see citing works

Maternal insulin resistance and transient hyperglycemia impact the metabolic and endocrine phenotypes of offspring

Kahraman, S., Dirice, E., Jesus, D. F. D., Hu, J., & Kulkarni, R. N. (2014) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00210.2014 · Cited by 49 · see citing works

Glucagon response to hypoglycemia is improved by insulin-independent restoration of normoglycemia in diabetic rats

Shi, Z. Q., Rastogi, K. S., Lekas, M. C., Efendić, S., Drucker, D. J., & Vranić, M. (1996) · Endocrinology · doi:10.1210/endo.137.8.8754739 · Cited by 45 · see citing works

Lack of glucagon response in glucose counter-regulation in Type 1 (insulin-dependent) diabetics: Absence of recovery after prolonged optimal insulin therapy

Bolli, G. B., Calabrese, G., Feo, P. D., Compagnucci, P., Zega, G., Angeletti, G., Cartechini, M. G., Santeusanio, F., & Brunetti, P. (1982) · Diabetologia · doi:10.1007/bf00254837 · Cited by 45 · see citing works

Somatostatin Receptor Subtype-2-Deficient Mice with Diet-Induced Obesity Have Hyperglycemia, Nonfasting Hyperglucagonemia, and Decreased Hepatic Glycogen Deposition

Singh, V., Grötzinger, C., Nowak, K. W., Zacharias, S., Göncz, E., Pleß, G., Sauer, I. M., Eichhorn, I., Pfeiffer-Guglielmi, B., Hamprecht, B., et al. (2007) · Endocrinology · doi:10.1210/en.2006-1659 · Cited by 44 · see citing works

Therapies for inter-relating diabetes and obesity – GLP-1 and obesity

Iepsen, E. W., Torekov, S. S., & Holst, J. J. (2014) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.2014.965678 · Cited by 43 · see citing works

The Role of Glucagon in the Pathophysiology and Management of Diabetes

Kulina, G., & Rayfield, E. J. (2016) · Endocrine Practice · doi:10.4158/ep15984.ra · Cited by 41 · see citing works

Diabetes: Rationale for Dipeptidyl Peptidase 4 Inhibitors: A New Class of Oral Agents for the Treatment of Type 2 Diabetes Mellitus

Campbell, R. K. (2006) · Annals of Pharmacotherapy · doi:10.1345/aph.1h459 · Cited by 39 · see citing works

The differential effect of animal versus vegetable dietary protein on the clinical manifestations of diabetic kidney disease in humans

Adeva‐Andany, M. M., Fernández‐Fernández, C., Carneiro-Freire, N., Vila-Altesor, M., & Ameneiros-Rodríguez, E. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.01.030 · Cited by 31 · see citing works

Chronic fractalkine administration improves glucose tolerance and pancreatic endocrine function

Riopel, M., Seo, J. B., Bandyopadhyay, G. K., Li, P., Wollam, J., Chung, H., Jung, S., Murphy, A. N., Wilson, M. E., de Jong, R., et al. (2018) · Journal of Clinical Investigation · doi:10.1172/jci94330 · Cited by 31 · see citing works

Pancreatic alpha cells in diabetic rats express active GLP-1 receptor: Endosomal co-localization of GLP-1/GLP-1R complex functioning through intra-islet paracrine mechanism

Nakashima, K., Kaneto, H., Shimoda, M., Kimura, T., & Kaku, K. (2018) · Scientific Reports · doi:10.1038/s41598-018-21751-w · Cited by 28 · see citing works

Antidiabetic Activity of a Highly Potent and Selective Nonpeptide Somatostatin Receptor Subtype-2 Agonist

Strowski, M. Z., Cashen, D. E., Birzin, E. T., Yang, L., Singh, V., Jacks, T. M., Nowak, K. W., Rohrer, S. P., Patchett, A. A., Smith, R. G., et al. (2006) · Endocrinology · doi:10.1210/en.2006-0274 · Cited by 24 · see citing works

Glucagon-like peptide-2, but not glucose-dependent insulinotropic polypeptide, stimulates glucagon release in patients with type 1 diabetes

Christensen, M., Knop, F. K., Vilsbøll, T., Aaboe, K., Holst, J. J., Madsbad, S., & Krarup, T. (2010) · Regulatory Peptides · doi:10.1016/j.regpep.2010.05.004 · Cited by 24 · see citing works

KATP channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca2+]c rise and an indirect inhibition mediated by somatostatin

Singh, B., Khattab, F., Chae, H., Desmet, L., Herrera, P. L., & Gilon, P. (2021) · Molecular Metabolism · doi:10.1016/j.molmet.2021.101268 · Cited by 22 · see citing works

Glucagon and Insulin Secretion

Samols, E. (1983) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-68866-9_22 · Cited by 23 · see citing works

Dipeptidyl peptidase 4 inhibition and vildagliptin therapy for type 2 diabetes

Prato, S. D. (2007) · International Journal of Clinical Practice · doi:10.1111/j.1742-1241.2007.01439.x · Cited by 15 · see citing works

Role of GLP-1 induced glucagon suppression in type 2 diabetes mellitus.

Hare, K. J. (2010) · PubMed · Cited by 14 · see citing works

Postprandial lipemia induces pancreatic α cell dysfunction characteristic of type 2 diabetes: studies in healthy subjects, mouse pancreatic islets, and cultured pancreatic α cells

Niederwanger, A., Ciardi, C., Tatarczyk, T., Khan, M. I., Hermann, M., Mittermair, C., Al‐Zoairy, R., Salzmann, K., & Pedrini, M. T. (2014) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.114.092023 · Cited by 12 · see citing works

Early postprandial glucagon surge affects postprandial glucose levels in obese and non-obese patients with type 2 diabetes

Kozawa, J., Okita, K., Iwahashi, H., Yamagata, K., Imagawa, A., & Shimomura, I. (2013) · Endocrine Journal · doi:10.1507/endocrj.ej13-0018 · Cited by 12 · see citing works

Hypothesis: Prostaglandins mediate defective glucose recognition in diabetes mellitus

Metz, S. A., McRae, J. R., & Robertson, R. P. (1980) · Prostaglandins and Medicine · doi:10.1016/0161-4630(80)90019-1 · Cited by 10 · see citing works

Effect of prolonged insulin treatment on blunted plasma catecholamine and glucagon increase during insulin hypoglycemia in streptozotocin diabetic rats

Patel, D. G. (1983) · Metabolism · doi:10.1016/0026-0495(83)90047-1 · Cited by 10 · see citing works

The ‘early’ postprandial glucagon response is related to the rate of gastric emptying in type 2 diabetes

Huang, W., Xie, C., Albrechtsen, N. J. W., Jones, K. L., Horowitz, M., Rayner, C. K., & Wu, T. (2023) · Peptides · doi:10.1016/j.peptides.2023.170941 · Cited by 8 · see citing works

Physiological and Pathophysiological Control of Glucagon Secretion by Pancreatic α-Cells

Gilon, P., Cheng, R., Lai, B. K., Chae, H., & Gómez-Ruiz, A. (2014) · Springer eBooks · doi:10.1007/978-94-007-6884-0_37-2 · Cited by 8 · see citing works

Paradoxical glucagon response in perifused islets of the diabetic Chinese hamster

Iwashima, Y., Watanabe, K., Eto, M., Morikawa, A., Takebe, T., & Ishii, K. (1985) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(86)80035-3 · Cited by 6 · see citing works

Gut Peptide Alterations in Type 2 Diabetes and Obesity: A Narrative Review

Tzeravini, E., Simati, S., Anastasiou, I. A., Dalamaga, Μ., & Kokkinos, A. D. (2026) · Current Obesity Reports · doi:10.1007/s13679-026-00687-7 · Cited by 4 · see citing works

Meal-derived glucagon responses are related to lower hepatic phosphate concentrations in obesity and type 2 diabetes

Weber, K. S., Straßburger, K., Fritsch, M., Bierwagen, A., Koliaki, C. C., Esther Phielix, E., Pacini, G., Hwang, J., Markgraf, D. F., Burkart, V., et al. (2018) · Diabetes & Metabolism · doi:10.1016/j.diabet.2018.05.008 · Cited by 4 · see citing works

Pharmacokinetics and pharmacodynamics of insulin aspart in patients with T ype 2 diabetes: Assessment using a meal tolerance test under clinical conditions

Ando, H., Kurita, S., Shimizu, A., Kato, K., Ishikura, K., Taji, K. N., Uno, M., Takeshita, Y., Misu, H., Fujimura, A., et al. (2012) · Clinical and Experimental Pharmacology and Physiology · doi:10.1111/j.1440-1681.2012.05708.x · Cited by 3 · see citing works

Physiological and Pathophysiological Control of Glucagon Secretion by Pancreatic α-Cells

Gilon, P., Cheng, R., Lai, B. K., Chae, H., & Gómez-Ruiz, A. (2014) · Springer eBooks · doi:10.1007/978-94-007-6686-0_37 · Cited by 3 · see citing works

Glucagon secretory responses to insulin-induced hypoglycemia and arginine in streptozotocin-induced diabetic dogs.

Gotoh, M., Okamura, J., Monden, M., & Shima, K. (1983) · Endocrinologia Japonica · doi:10.1507/endocrj1954.30.443 · Cited by 2 · see citing works

Clinical Mechanistic Profiling of a Novel DPP-4 Inhibitor, Vildagliptin, for the Treatment of Type 2 Diabetes Mellitus

He, Y. (2011) · Rinsho yakuri/Japanese Journal of Clinical Pharmacology and Therapeutics · doi:10.3999/jscpt.42.279 · Cited by 1 · see citing works

Pathogenesis of impaired glucose tolerance and its relationship to hemodynamics in patients with acute myocardial infarction.

Tanaka, K. (1985) · Journal of Nippon Medical School · doi:10.1272/jnms1923.52.58 · Cited by 1 · see citing works

Mechanism on the Blunted Glucagon Response to Insulin-induced Hypoglycemia in Diabetics

Katsura, M. (1986) · Folia Endocrinologica Japonica · doi:10.1507/endocrine1927.62.11_1276 · Cited by 1 · see citing works

Impact of antibiotic use, alternative therapies and inflammation on the intestinal microbiota

Overstreet, A.-M. C. (2012) · doi:10.31274/etd-180810-1992

The Effects of Incretin Mimetics on Islet Cell Function in Type 2 Diabetes

Marchetti, P., & Boggi, U. (2008) · touchREVIEWS in Endocrinology · doi:10.17925/ee.2008.04.02.50

Insuppressibility of plasma glucagon by orally or intravenously administered glucose in diabetes mellitus.

Kurahachi, H., Seino, Y., Ikeda, M., Sakurai, H., Yoshimi, T., & Imura, H. (1977) · Endocrinologia Japonica · doi:10.1507/endocrj1954.24.413 · Cited by 4 · see citing works

Abnormal Alpha Cell Function in Diabetics Response to Insulin

Unger, R. H., Madison, L. L., & Müller, W. A. (1972) · Diabetes · doi:10.2337/diab.21.5.301 · Cited by 89 · see citing works

Studies of pancreatic alpha cell function in normal and diabetic subjects

Unger, R. H., Aguilar-Parada, E., Müller, W. A., & Eisentraut, A. M. (1970) · Journal of Clinical Investigation · doi:10.1172/jci106297 · Cited by 837 · see citing works

ABNORMALITIES OF GLUCAGON METABOLISM IN UNTREATED DIABETES MELLITUS

Buchanan, K. D., & Mccarroll, A. M. (1972) · The Lancet · doi:10.1016/s0140-6736(72)92964-9 · Cited by 97 · see citing works

Glucagon in Diabetes Mellitus

Unger, R. H., & Orci, L. (1983) · Handbook of experimental pharmacology · doi:10.1007/978-3-642-69019-8_22 · Cited by 10 · see citing works