Comparative Effectiveness of Dextrothyroxine and Levothyroxine in Correcting Hypothyroidism and Lowering Blood Lipid Levels in Hypothyroid Patients
Abstract
Data reported here establish that treatment regimens of 4 mg dextrothyroxine and 0.15 mg levothyroxine in hypothyroid subjects produce similar degrees of lowering of serum TSH, cholesterol, triglycerides, and phospholipid levels and equal stimulation of metabolic rate. The Murphy-Pattee total T4 determination applied to blood samples drawn 24 h after the last dose of dextrothyroxine can be used to assess adequacy of treatment. Correction of hypothyroidism requires high serum levels of dextrothyroxine than of levothyroxine. Serum T3 levels increase in patients treated with dextrothyroxine. In the treatment of hypothyroidism, the cholesterol-lowering and metabolic rate-stimulating effects of dextrothyroxine do not appear to be dissociated. Further studies are needed to determine whether such an effect can be demonstrated in euthyroid hypercholesterolemic subjects with doses established herein as equivalent in terms of the stimulating effect on metabolic rate.
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Compared with normal individuals with similar TSH levels, LT4-treated patients exhibit a slightly lower basal metabolic rate.
“exhibit a slightly lower basal metabolic rate (BMR) (15,17,18)”
From Liothyronine and Desiccated Thyroid Extract in the Treatment of Hypothyroidism (2020) · cites this paper as [17]
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- Authors
- GORMAN, C. A., JIANG, N.-S., ELLEFSON, R. D., & ELVEBACK, L. R.
- Affiliations
- Mayo Clinic (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1979-07
- Volume
- 49
- Issue
- 1
- Pages
- 1-7
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1992880394
- Cited by
- 56
- References
- 0
- Citations by year
- 2026: 2 · 2025: 1 · 2023: 1 · 2022: 5 · 2021: 3 · 2020: 3 · 2019: 2 · 2018: 2 · 2017: 2 · 2016: 2 · 2015: 2
- FWCI
- 2.45
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Health Sciences › Medicine › Surgery › Thyroid and Parathyroid Surgery
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
- Keywords
- dextrothyroxine, levothyroxine, hypothyroidism, thyroid hormone replacement, serum cholesterol, triglycerides, phospholipids, thyroid-stimulating hormone, metabolic rate, serum T3, hypercholesterolemia
- MeSH terms
- Basal Metabolism, Cholesterol, Dose-Response Relationship, Drug, Humans, Hypothyroidism, Phospholipids, Stereoisomerism, Thyrotropin, Thyroxine, Triglycerides
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