Thyroid hormone resistance: mechanisms and therapeutic development

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The c-erb-A gene encodes a thyroid hormone receptor

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Molecular Aspects of Thyroid Hormone Actions

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The c-erb-A protein is a high-affinity receptor for thyroid hormone

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Regulation of Transcription by a Protein Methyltransferase

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A structural role for hormone in the thyroid hormone receptor

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Identification of monocarboxylate transporter 8 as a specific thyroid hormone transporter

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Association between mutations in a thyroid hormone transporter and severe X-linked psychomotor retardation

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Familial Syndrome Combining Deaf-Mutism, Stippled Epiphyses, Goiter and Abnormally High PBI: Possible Target Organ Refractoriness to Thyroid Hormone¹²

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Structural determinants of nuclear receptor assembly on DNA direct repeats

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Whole-genome sequencing of quartet families with autism spectrum disorder

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Germline mutations in the Von Hippel-Lindau disease (VHL) gene in families from North America, Europe, and Japan

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Mutations in SECISBP2 result in abnormal thyroid hormone metabolism

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Thyroid hormone receptors and resistance to thyroid hormone disorders

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A Mutation in the Thyroid Hormone Receptor Alpha Gene

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Point mutation causing a single amino acid substitution in the hormone binding domain of the glucocorticoid receptor in familial glucocorticoid resistance

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Deiodinases and their intricate role in thyroid hormone homeostasis

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Isolation and characterization of chicken DNA homologous to the two putative oncogenes of avian erythroblastosis virus

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Mutations in the selenocysteine insertion sequence-binding protein 2 gene lead to a multisystem selenoprotein deficiency disorder in humans

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Transcriptional repression by nuclear hormone receptors.

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Central Hypothyroidism: Pathogenic, Diagnostic, and Therapeutic Challenges

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Syndromes of reduced sensitivity to thyroid hormone: genetic defects in hormone receptors, cell transporters and deiodination

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Paradigms of dynamic control of thyroid hormone signaling

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Cloning and Characterization of Two Novel Thyroid Hormone Receptor β Isoforms

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A high-affinity subtype-selective agonist ligand for the thyroid hormone receptor

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Targeting thyroid hormone receptor-β agonists to the liver reduces cholesterol and triglycerides and improves the therapeutic index

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Generalized resistance to thyroid hormone associated with a mutation in the ligand-binding domain of the human thyroid hormone receptor beta.

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The dimerization interfaces formed between the DNA binding domains of RXR, RAR and TR determine the binding specificity and polarity of the full‐length receptors to direct repeats.

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The syndromes of reduced sensitivity to thyroid hormone

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The Effect of Thyroid Hormone on Skeletal Integrity

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Characterization of seven novel mutations of the c-erbA beta gene in unrelated kindreds with generalized thyroid hormone resistance. Evidence for two "hot spot" regions of the ligand binding domain.

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Discovery of 2-[3,5-Dichloro-4-(5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yloxy)phenyl]-3,5-dioxo-2,3,4,5-tetrahydro[1,2,4]triazine-6-carbonitrile (MGL-3196), a Highly Selective Thyroid Hormone Receptor β Agonist in Clinical Trials for the Treatment of Dyslipidemia

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An Online Survey of Hypothyroid Patients Demonstrates Prominent Dissatisfaction

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Genetic analysis of 29 kindreds with generalized and pituitary resistance to thyroid hormone. Identification of thirteen novel mutations in the thyroid hormone receptor beta gene.

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2018 European Thyroid Association (ETA) Guidelines on the Diagnosis and Management of Central Hypothyroidism

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Clinical Phenotype and Mutant TRα1

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Thyroid Hormone Resistance Syndrome Manifests as an Aberrant Interaction between Mutant T3 Receptors and Transcriptional Corepressors

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Thyroid Hormone Transporters

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European Society for Paediatric Endocrinology consensus guidelines on screening, diagnosis, and management of congenital hypothyroidism

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Thyroid hormone signaling and the liver

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A base mutation of the C-erbA beta thyroid hormone receptor in a kindred with generalized thyroid hormone resistance. Molecular heterogeneity in two other kindreds.

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Transcriptional repression of Xenopus TR beta gene is mediated by a thyroid hormone response element located near the start site.

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Identification of Transcripts Initiated from an Internal Promoter in the c-erbAα Locus That Encode Inhibitors of Retinoic Acid Receptor-α and Triiodothyronine Receptor Activities

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Tight Linkage between the Syndrome of Generalized Thyroid Hormone Resistance and the Human c-erbAβ Gene

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Thyroid hormone receptor-associated proteins and general positive cofactors mediate thyroid hormone receptor function in the absence of the TATA box-binding protein-associated factors of TFIID

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Thyroid Hormone Signaling Pathways: Time for a More Precise Nomenclature

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Structural Rearrangements in the Thyroid Hormone Receptor Hinge Domain and Their Putative Role in the Receptor Function

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Ligand selectivity by seeking hydrophobicity in thyroid hormone receptor

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Detection and treatment of congenital hypothyroidism

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Thyroxine-thyroid hormone receptor interactions

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SUCCESSFUL LABORATORY SCREENING FOR CONGENITAL HYPOTHYROIDISM

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Identical mutations in unrelated families with generalized resistance to thyroid hormone occur in cytosine-guanine-rich areas of the thyroid hormone receptor beta gene. Analysis of 15 families.

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Spectrum of transcriptional, dimerization, and dominant negative properties of twenty different mutant thyroid hormone beta-receptors in thyroid hormone resistance syndrome

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A role for helix 3 of the TRβ ligand‐binding domain in coactivator recruitment identified by characterization of a third cluster of mutations in resistance to thyroid hormone

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Molecular Functions of Thyroid Hormone Signaling in Regulation of Cancer Progression and Anti-Apoptosis

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An Adult Female With Resistance to Thyroid Hormone Mediated by Defective Thyroid Hormone Receptor α

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Thyroid Receptor Ligands. 1. Agonist Ligands Selective for the Thyroid Receptor β1

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Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor gamma-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population

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Thyroid hormone receptor localization in target tissues

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Thyroid Hormone Receptor Coactivators and Corepressors

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A Homozygous Deletion in the c-erbAβ Thyroid Hormone Receptor Gene in a Patient with Generalized Thyroid Hormone Resistance: Isolation and Characterization of the Mutant Receptor

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Selective Thyroid Hormone Receptor-Beta (TRβ) Agonists: New Perspectives for the Treatment of Metabolic and Neurodegenerative Disorders

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6 Mineralocorticoid resistance

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Dominant negative activity of an endogenous thyroid hormone receptor variant (alpha 2) is due to competition for binding sites on target genes.

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Genome-wide analysis of thyroid hormone receptors shared and specific functions in neural cells

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DITPA (3,5-Diiodothyropropionic Acid), a Thyroid Hormone Analog to Treat Heart Failure: Phase II Trial Veterans Affairs Cooperative Study

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Clinical and Molecular Characterization of a Novel Selenocysteine Insertion Sequence-Binding Protein 2 (SBP2) Gene Mutation (R128X)

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Structural and functional insights into nuclear receptor signaling

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Transport of Thyroid Hormone in Brain

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