The DOI matches its Crossref record.
Different Types of Melatonin Circadian Secretory Rhythms in Some Blind Subjects
Abstract
Six of 10 blind subjects had unusual melatonin circadian secretory patterns. One of these subjects, studied longitudinally, appeared to have a free-running melatonin secretory rhythm with a period of 24.7 h. Another subject, also studied longitudinally, appeared to secrete melatonin during the day (instead of during the night). Therefore, some blind subjects appear to have different types of circadian rhythm abnormalities. These findings along with previous work demonstrating suppression of human melatonin secretion by light suggest that the light-dark cycle may be important in the regulation of the human melatonin circadian secretory rhythm. These findings may stimulate more research on the endocrinological consequences of blindness as well as on the biological effects of light in humans.
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Citations
Cited by
Brzezinski, A. (1997) · New England Journal of Medicine · doi:10.1056/nejm199701163360306 · Cited by 1,549
Entrainment of free-running circadian rhythms by melatonin in blind people
Sack, R. L., Brandes, R. W., Kendall, A. R., & Lewy, A. J. (2000) · New England Journal of Medicine · doi:10.1056/nejm200010123431503 · Cited by 490
Self-citationThe Dim Light Melatonin Onset as a Marker for Orcadian Phase Position
Lewy, A. J., & Sack, R. L. (1989) · Chronobiology International · doi:10.3109/07420528909059144 · Cited by 418
Self-citationNonphotic Entrainment in Humans?
Mistlberger, R. E., & Skene, D. J. (2005) · Journal of Biological Rhythms · doi:10.1177/0748730405277982 · Cited by 267
Tan, D., Xu, B., Zhou, X., & Reiter, R. (2018) · Molecules · doi:10.3390/molecules23020301 · Cited by 220
Metadata
- Authors
- Lewy, A. J., & Newsome, D. A.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1983-06
- Volume
- 56
- Issue
- 6
- Pages
- 1103-1107
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2044968935
- Cited by
- 204
- References
- 0
- FWCI
- 1.78
- Type
- journal article
- Language
- en
- Open access
- closed
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- Lewy, A. J., & Newsome, D. A. (1983). Different Types of Melatonin Circadian Secretory Rhythms in Some Blind Subjects. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-56-6-1103
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