The DOI matches its Crossref record; 19 of the 19 references it cites were found in a registry or an index.
Somatomedins in adolescence: a cross-sectional study of the effect of puberty on plasma insulin-like growth factor I and II levels
Abstract
To explore the effect of puberty on the somatomedins (SMs), a group of insulin-like peptides which mediate the action of GH on skeletal tissue, we measured SM-C/insulin-like growth factor-I (SM-C/IGF-I) and IGF-II by specific RIAs in 110 adolescents between the ages of 10 and 18 yr. All subjects were in good health and between the 5th and 95th percentiles for height. In both females and males, SM-C/IGF-I levels rose during puberty to a peak approximately 3-fold higher than the average adult level. The rise in SM-C/IGF-I levels corresponded better with the Tanner stage of the adolescents than with their chronological age. IGF-II levels did not rise during puberty and were slightly below adult levels. The dramatic rise in SM-C/IGF-I levels during puberty suggests a role for this SM peptide in the adolescent growth spurt. Furthermore, these data indicate that proper interpretation of SM-C/IGF-I levels during adolescence must include a knowledge of the patient's pubertal development.
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“Moreover, studies show an increase in IGF-1 expression during puberty in human beings.109”
From Pubertal development and regulation (2016) · cites this paper as [109]
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Cites
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Variations in the pattern of pubertal changes in boys
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Physical growth: National Center for Health Statistics percentiles
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Items 201–204 of 204
Childhood Growth Hormone Deficiency and Hypopituitarism
Cohen, L. E., Soto-Rivera, C. L., & Romero, C. J. (2024) · Springer eBooks · doi:10.1007/978-3-031-66296-6_1
The Somatomedin Hypothesis of Growth Hormone Action
Hintz, R. L. (1998) · Comprehensive physiology · doi:10.1002/j.2040-4603.1998.tb01545.x
Mills, A. M., & Noble, E. E. (2026) · Appetite · doi:10.1016/j.appet.2026.108729
Shahab, M., Trujillo, M. V., & Plant, T. M. (2015) · Endocrinology · doi:10.1210/en.2015-1421
Metadata
- Authors
- LUNA, A. M., WILSON, D. M., WIBBELSMAN, C. J., BROWN, R. C., NAGASHIMA, R. J., HINTZ, R. L., & ROSENFELD, R. G.
- Affiliations
- San Francisco General Hospital (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1983-08
- Volume
- 57
- Issue
- 2
- Pages
- 268-271
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2159795530
- Cited by
- 204
- References
- 19
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 1 · 2014: 6 · 2013: 1 · 2012: 3
- FWCI
- 12.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Human Health and Disease
- Keywords
- insulin-like growth factor, insulin-like growth factor I, insulin-like growth factor II, puberty, adolescents, growth spurt, plasma IGF-I levels, Tanner stages, growth hormone, skeletal development
- MeSH terms
- Adolescent, Aging, Child, Cross-Sectional Studies, Female, Humans, Insulin, Male, Peptides, Puberty, Somatomedins
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