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Somatomedins in adolescence: a cross-sectional study of the effect of puberty on plasma insulin-like growth factor I and II levels
Abstract
To explore the effect of puberty on the somatomedins (SMs), a group of insulin-like peptides which mediate the action of GH on skeletal tissue, we measured SM-C/insulin-like growth factor-I (SM-C/IGF-I) and IGF-II by specific RIAs in 110 adolescents between the ages of 10 and 18 yr. All subjects were in good health and between the 5th and 95th percentiles for height. In both females and males, SM-C/IGF-I levels rose during puberty to a peak approximately 3-fold higher than the average adult level. The rise in SM-C/IGF-I levels corresponded better with the Tanner stage of the adolescents than with their chronological age. IGF-II levels did not rise during puberty and were slightly below adult levels. The dramatic rise in SM-C/IGF-I levels during puberty suggests a role for this SM peptide in the adolescent growth spurt. Furthermore, these data indicate that proper interpretation of SM-C/IGF-I levels during adolescence must include a knowledge of the patient's pubertal development.
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“Moreover, studies show an increase in IGF-1 expression during puberty in human beings.109”
From Pubertal development and regulation (2016) · cites this paper as [109]
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Metadata
- Authors
- LUNA, A. M., WILSON, D. M., WIBBELSMAN, C. J., BROWN, R. C., NAGASHIMA, R. J., HINTZ, R. L., & ROSENFELD, R. G.
- Affiliations
- San Francisco General Hospital (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1983-08
- Volume
- 57
- Issue
- 2
- Pages
- 268-271
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2159795530
- Cited by
- 204
- References
- 19
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 2 · 2020: 2 · 2019: 3 · 2018: 3 · 2017: 1 · 2016: 6 · 2015: 1 · 2014: 6 · 2013: 1 · 2012: 3
- FWCI
- 12.69
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Health Sciences › Medicine › Reproductive Medicine › Hypothalamic control of reproductive hormones
- Health Sciences › Medicine › Pediatrics, Perinatology and Child Health › Human Health and Disease
- Keywords
- insulin-like growth factor, insulin-like growth factor I, insulin-like growth factor II, puberty, adolescents, growth spurt, plasma IGF-I levels, Tanner stages, growth hormone, skeletal development
- MeSH terms
- Adolescent, Aging, Child, Cross-Sectional Studies, Female, Humans, Insulin, Male, Peptides, Puberty, Somatomedins
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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