The DOI matches its Crossref record; 12 of the 13 references it cites were found in a registry or an index.
Effect of 64-Hour Sleep Deprivation on the Circadian Waveform of Thyrotropin (TSH): Further Evidence of Sleep-Related Inhibition of TSH Release*
Abstract
Half-hourly sampling of plasma TSH was done across 3 days in four normal young men. Sleep was denied for 64 h from 0700 h on awakening from accommodation sleep until polygraphic sleep was resumed at 7100 h of the third day (D3) such that 2 consecutive nights of usual 2300-0700 h sleep were missed. This protocol allowed examination of any modulatory effects on the daily patterns in TSH concentrations during sleep deprivation on D1-2 (1100-3500, 3500-5900 h) or during resumption of usual nightly sleep on D3 (5900-8300) compared to that of a previously studied group of normal young men. The circadian nature of the daily TSH waveform was evidenced by its daily repetition within a subject both basally and during D1-2 sleep deprivation and by its synchronization within the basal, deprived, or resumed sleep days. The peaks in each subject's daily TSH patterns on D1-2 were consistently longer, and the daily maxima and cosine acrophases on D1-2 were consistently later than those on D3 when basal sleep was resumed. About half the daily TSH concentration maxima and daily cosinor amplitudes on D1-2 were greater than those of the respective sleep-resumed TSH patterns of D3. Both the group mean TSH patterns and the cosinor 95% confidence ellipses also indicated the daily peak in the TSH waveform to be significantly longer, later, and larger during D1-2 sleep deprivation than during the basal or D3 periods. These results indicate that significant alteration of the daily TSH waveform can occur in response to absence of sleep and are compatible with the existence of an inhibitory effect in early nightly sleep on TSH release. The TSH patterns during the 1700-2300 h intervals of rising TSH levels were congruent in the basal, deprived, and resumed sleep periods. Prompt reversion to the basal TSH pattern also occurred when sleep was resumed on D3. Both of these observations suggest the alteration in TSH waveform during sleep deprivation to have arisen from an inhibitory effect in sleep rather than from a change in period or phase of a generating oscillator.
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“The relationship between sleep and metabolism has been extensively studied in human subjects under varying conditions, such as total sleep deprivation,87–100 partial sleep deprivation,101–122 and sleep fragmentation123–125 (Table 1).”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [88]
In the citing paper
“Acute total sleep deprivation increased TSH and free T4 levels,88 whereas partial sleep deprivation of 5.5-h nights for two weeks or six 4-h nights decreased TSH and T4 levels, suggesting a dose-related effect104,116”
From Interacting epidemics? Sleep curtailment, insulin resistance, and obesity (2012) · cites this paper as [88]
Citations
Cites
Rechtschaffen, A. (1968) · Medical Entomology and Zoology · Cited by 11,772
Franz Halberg, A., Carandente, F., Cornelissen-Guillaume, G. G., & Katinas, G. (1977) · Chronobiologia · Cited by 269
A Sensitive and Precise Radioimmunoassay for Human Thyroid-Stimulating Hormone
PEKARY, A. E., Hershman, J. M., & Parlow, A. F. (1975) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-41-4-676 · Cited by 154
Self-citationCIRCADIAN AND 30 MINUTES VARIATIONS IN SERUM TSH AND THYROID HORMONES IN NORMAL SUBJECTS
Weeke, J., & Gundersen, H. J. G. (1978) · European Journal of Endocrinology · doi:10.1530/acta.0.0890659 · Cited by 134
PARKER, D. C., Pekary, A. E., & Hershman, J. M. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-43-2-318 · Cited by 134
Self-citationPlasma Thyrotropin, Thyroxine, and Triiodothyronine Relationships in Man
AZUKIZAWA, M., Pekary, A. E., Hershman, J. M., & PARKER, D. C. (1976) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-43-3-533 · Cited by 114
Self-citationChan, V. W., Jones, A. E., Liendo-Ch, P., McNeilly, A. S., Landon, J., & BESSER, G. M. (1978) · Clinical Endocrinology · doi:10.1111/j.1365-2265.1978.tb02219.x · Cited by 66
Circadian rhythm of TSH in adult men and women
Custro, N., & Scaglione, R. (1980) · European Journal of Endocrinology · doi:10.1530/acta.0.0950465 · Cited by 37
Endocrine Rhythms across Sleep-Wake Cycles in Normal Young Men under Basal State Conditions
PARKER, D. C., ROSSMAN, L. G., Kripke, D. F., Hershman, J. M., Gibson, W., Davis, C. W., Wilson, K., & Pekary, E. (1980) · Elsevier eBooks · doi:10.1016/b978-0-12-527650-4.50010-4 · Cited by 26
Self-citationTwenty-four hour profile of integrated TSH concentration in puberty
Minuto, F. M., Bagnasco, M., Giusti, M., Grimaldi, G., Biassoni, P., Ferrini, O., & Giordano, G. (1981) · Journal of Endocrinological Investigation · doi:10.1007/bf03349406 · Cited by 14
Cited by
Sorted by citations
Physiological regulation of circadian and pulsatile thyrotropin secretion in normal man and woman
BRABANT, G., PRANK, K., RANFT, U., SCHUERMEYER, T., WAGNER, T. O. F., HAUSER, H., KUMMER, B., FEISTNER, H., HESCH, R. D., & MÜHLEN, A. V. Z. (1990) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-70-2-403 · Cited by 282
Sleep, sleep disturbance, and fertility in women
Kloss, J. D., Perlis, M. L., Zamzow, J. A., Culnan, E., & Gracia, C. R. (2014) · Sleep Medicine Reviews · doi:10.1016/j.smrv.2014.10.005 · Cited by 228
Interacting epidemics? Sleep curtailment, insulin resistance, and obesity
Lucassen, E. A., Rother, K. I., & Cizza, G. (2012) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2012.06655.x · Cited by 191
ALTERATIONS WITH AGING OF THE ENDOCRINE AND NEUROENDOCRINE CIRCADIAN SYSTEM IN HUMANS
Touitou, Y., & Haus, E. L. (2000) · Chronobiology International · doi:10.1081/cbi-100101052 · Cited by 169
Leproult, R., Van Onderbergen, A., L’Hermite‐Balériaux, M., Van Cauter, E., & Copinschi, G. (2005) · Clinical Endocrinology · doi:10.1111/j.1365-2265.2005.02341.x · Cited by 167
Metadata
- Authors
- PARKER, D. C., ROSSMAN, L. G., PEKARY, A. E., & HERSHMAN, J. M.
- Affiliations
- United States Department of Veterans Affairs (US)
- ORCID
- PEKARY, A. EUGENE
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1987-01
- Volume
- 64
- Issue
- 1
- Pages
- 157-161
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2083364347
- Cited by
- 114
- References
- 13
- Citations by year
- 2026: 1 · 2025: 2 · 2024: 1 · 2023: 4 · 2022: 5 · 2021: 11 · 2020: 3 · 2019: 2 · 2018: 3 · 2017: 2 · 2016: 4 · 2015: 1 · 2014: 2 · 2013: 2 · 2012: 4
- FWCI
- 2.91
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
- Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Thyroid Disorders and Treatments
- Keywords
- sleep deprivation, thyroid-stimulating hormone, cosinor analysis, hypothalamic-pituitary-thyroid axis
- MeSH terms
- Adult, Circadian Rhythm, Humans, Male, Sleep Deprivation, Thyrotropin, Time Factors
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