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Cited by 167Circadian rhythm and melatoninSleep and Work-Related FatigueSleep and related disorders

Phase‐shifts of 24‐h rhythms of hormonal release and body temperature following early evening administration of the melatonin agonist agomelatine in healthy older men

Leproult, Rachel, Van Onderbergen, Anne, L’Hermite‐Balériaux, Mireille, Van Cauter, Eve, Copinschi, Georges·2005·Clinical Endocrinology
DOI 10.1111/j.1365-2265.2005.02341.x
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Abstract

Summary: Objective Older adults are less responsive to the phase‐shifting effects of light than younger subjects and may have difficulties adapting to abrupt time shifts. This study aims to determine whether the potent melatonin agonist agomelatine (S‐20098) is capable of phase‐shifting overt circadian rhythms in older adults. Subjects and design Eight healthy elderly men participated in a double‐blind, two‐period, cross‐over study of 15 days of daily administration of either agomelatine (50 mg) or placebo at 1830 h. Measurements At the end of each treatment period, the 24‐h profiles of body temperature and of the plasma levels of GH, PRL, cortisol and TSH were collected and sleep was monitored polygraphically. Results Phase‐advances, averaging nearly 2 h, were observed for the temperature profile and for the variables characterizing the temporal organization of cortisol secretion following agomelatine administration. A similar trend was observed for the circadian rise of plasma TSH. There was no effect of agomelatine on any of the sleep variables. Agomelatine stimulated GH secretion during the wake period and was associated with a transient elevation of PRL levels. Conclusions Melatonin agonists such as agomelatine may be useful to phase‐shift at least some overt circadian rhythms in older adults.

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Crossref · 10.1111/j.1365-2265.2005.02341.x

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  • Administration of antidepressants (SSRIs, SNIRs, and agomelatine) results in phase advancement of circadian rhythms (melatonin, body temperature, activity, and cortisol rhythms).

    “Additionally, administration of antidepressants (SSRIs, SNIRs, and agomelatine [MT1, MT2 agonist and 5HT2c antagonist) result in a phase advancement of circadian rhythms (i.e., melatonin, body temperature, activity, and cortisol rhythms)85,86.”

    From Circadian rhythm disruption and mental health (2020) · cites this paper as [85]

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Authors
Leproult, R., Van Onderbergen, A., L’Hermite‐Balériaux, M., Van Cauter, E., & Copinschi, G.
Affiliations
Université Libre de Bruxelles (BE)
Corresponding author
Leproult, Rachel
ORCID
Venue
Clinical Endocrinology
Publisher
Wiley
Published
2005-08-02
Volume
63
Issue
3
Pages
298-304
ISSN
  • 0300-0664 (ISSN-L)
  • 1365-2265
DOI
10.1111/j.1365-2265.2005.02341.x
OpenAlex
W2080424914
Cited by
167
References
50
Citations by year
2026: 1 · 2025: 1 · 2024: 2 · 2023: 2 · 2022: 2 · 2021: 7 · 2020: 4 · 2019: 6 · 2018: 7 · 2017: 3 · 2016: 7 · 2015: 7 · 2014: 6 · 2013: 16 · 2012: 7
FWCI
4.66
Type
journal article
Language
en
Open access
closed
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)
Locations
  • Clinical Endocrinology (publishedVersion)
  • PubMed (publishedVersion)
  • Dépôt institutionnel de l'Université libre de Bruxelles (Université Libre de Bruxelles) (submittedVersion)
Funders
  • National Institutes of Health
  • National Institute on Aging (P01AG011412, AG-11412)
Topics
  • Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Circadian rhythm and melatonin
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and Work-Related Fatigue
  • Social Sciences › Psychology › Experimental and Cognitive Psychology › Sleep and related disorders
Keywords
agomelatine, melatonin receptor agonists, circadian phase shifting, older adults, body temperature rhythm, cortisol secretion, growth hormone, prolactin, thyroid-stimulating hormone, sleep, chronobiology
MeSH terms
Acetamides, Aged, Body Temperature, Circadian Rhythm, Double-Blind Method, Hormones, Humans, Hydrocortisone, Male, Melatonin, Middle Aged, Monitoring, Physiologic, Naphthalenes, Prolactin, Sleep, Growth Hormone, Stimulation, Chemical, Thyrotropin, Cross-Over Studies, Jet Lag Syndrome

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