The DOI matches its Crossref record; 21 of the 21 references it cites were found in a registry or an index.
Clearance Studies of Oxytocin in Humans Using Radioimmunoassay Measurements of the Hormone in Plasma and Urine*
Abstract
Synthetic oxytocin (OT) was infused iv in four men at 3 mU/min, and the rate was doubled every 90 min for a total of three infusion periods. The mean (+/- SEM) OT MCR was 16.4 +/- 1.7 ml/kg X min and was independent of the rate of infusion. A method for measuring OT in urine was developed using an octadecasilyl-silica column for extraction of the hormone. The extracted residue was reconstituted in potassium phosphate buffer, pH 7.4, for RIA. The minimum detectable level of OT in urine was 0.2 microU/ml (defined as a bound to free ratio of approximately 90%). The mean recovery of OT was 77 +/- 2%. The mean (+/- SEM) concentration of endogenous OT in urine was 10.2 +/- 1.4 microU/ml. Endogenous OT in urine eluted from a reverse phase high pressure liquid chromatography column as a single peak of OT immunoreactivity in the position of synthetic OT. Urinary OT excretion during infusion of synthetic OT was linearly correlated with plasma OT concentration whether calculated as microunits of urinary OT per mg creatinine (r = 0.89) or urinary OT per min (r = 0.93). Mean urinary fractional clearance of OT (OT clearance/creatinine clearance) was 3.6% renal clearance of OT (5.5 ml/min or 0.43% of MCR). Thus, OT MCR was constant over a wide range of physiological plasma OT levels and was similar to MCR in pregnant women studied previously in this laboratory. Less than 1% of OT was cleared in urine. This study defines the relationship between urinary and plasma OT during steady state infusion of physiological concentrations of the hormone and indicates that measurements of OT in urine by RIA may prove helpful for pharmacokinetic and physiological studies of OT-related events in humans.
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In the citing paper
“We took the clearance of oxytocin into urine in chimpanzees to be 15 to 60 min after secretion (19, 20), adapted from a human clearance study (43).”
From Oxytocin reactivity during intergroup conflict in wild chimpanzees (2017) · cites this paper as [43]
In the citing paper
“Specifically, urine was collected 15 -60 min after the target behaviour (time window of urinary clearance of oxytocin for primates [65]).”
From Food sharing is linked to urinary oxytocin levels and bonding in related and unrelated wild chimpanzees (2014) · cites this paper as [65]
In the citing paper
“For humans and the common marmoset, radiolabeled studies have indicated a time course from circulation into the urine as 30–60 min for peak levels to appear (Amico et al., 1987; Seltzer and Ziegler, 2007). This indicates that when examining responses to an event, the desired collection time would be within this window and the window appears to be consistent across the primate order.”
From Endogenous peripheral oxytocin measures can give insight into the dynamics of social relationships: a review (2014) · cites this paper as Amico et al., 1987
Citations
Cites
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Winer, B. J. (1962) · McGraw-Hill Book Company · doi:10.1037/11774-000 · Cited by 27,137
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Johnson, A., & Wichern, D. W. (1988) · Biometrics · doi:10.2307/2531616 · Cited by 11,374
Statistical Quality Control of Radioimmunoassays1
Rodbard, D., Rayford, P. L., COOPER, J. A., & ROSS, G. T. (1968) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-28-10-1412 · Cited by 322
Oxytocin in Human Plasma: Correlation with Neurophysin and Stimulation with Estrogen*
Amico, J. A., SEIF, S. M., & ROBINSON, A. G. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-52-5-988 · Cited by 177
Self-citationA new extraction of arginine vasopressin from blood: The use of octadecasilyl-silica
Larochelle, F. T., North, W. G., & Stern, P. (1980) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/bf00580849 · Cited by 145
CHARD, T., BOYD, N. R. H., FORSLING, M. L., McNEILLY, A. S., & LANDON, J. (1970) · Journal of Endocrinology · doi:10.1677/joe.0.0480223 · Cited by 140
Weitzman, R. E., GLATZ, T. H., & Fisher, D. A. (1978) · Endocrinology · doi:10.1210/endo-103-6-2154 · Cited by 130
Fabian, M., Forsling, M. L., Jones, J. J., & Pryor, J. S. (1969) · The Journal of Physiology · doi:10.1113/jphysiol.1969.sp008937 · Cited by 107
Johnston, J. M., & Amico, J. A. (1986) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-62-4-653 · Cited by 104
Self-citationPlasma oxytocin levels during human pregnancy and labor as determined by radioimmunoassay
Kumaresan, P., Anandarangam, P. B., Dianzon, W., & Vasicka, A. (1974) · American Journal of Obstetrics and Gynecology · doi:10.1016/0002-9378(74)90037-4 · Cited by 99
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Gnanadesikan, G. E., Hammock, E. A. D., Tecot, S. R., Lewis, R. J., Hart, R., Carter, C. S., & MacLean, E. L. (2022) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2022.03.03.482682
Urinary oxytocin levels in children meeting a Hospital Dog®
Risberg, A., Larsson, A., Bodén, U., & Edner, A. (2025) · BMC Complementary Medicine and Therapies · doi:10.1186/s12906-025-05076-6
Kapteijn, C. M., Vinke, C. M., van Lith, H. A., Endenburg, N., Rodenburg, T. B., & Rault, J. (2025) · Applied Animal Behaviour Science · doi:10.1016/j.applanim.2025.106826
A multiscale PBPK‐PD model of oxytocin‐induced uterine excitation and contraction
Yang, Y., Bradley, C. P., Zhang, X., Clark, A. R., Gao, M., Li, G., Yang, L., Ortiz, I. R. M., Meng, Y., Hao, D., et al. (2026) · The Journal of Physiology · doi:10.1113/jp291462
Metadata
- Authors
- AMICO, J. A., ULBRECHT, J. S., & ROBINSON, A. G.
- Affiliations
- University of Pittsburgh (US)
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1987-02
- Volume
- 64
- Issue
- 2
- Pages
- 340-345
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W1969668906
- Cited by
- 105
- References
- 21
- Citations by year
- 2026: 2 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 9 · 2018: 10 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 5 · 2012: 5
- FWCI
- 2.03
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
- PubMed (publishedVersion)
- Funders
- University of Pittsburgh
- National Institutes of Health (5r01hd019787-03, 5r01am016166-12)
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (1R01-HD-19787)
- Topics
- Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
- Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
- Keywords
- oxytocin, renal clearance, endogenous oxytocin, pharmacokinetics
- MeSH terms
- Adult, Chromatography, High Pressure Liquid, Humans, Male, Mathematics, Metabolic Clearance Rate, Oxytocin, Radioimmunoassay
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