Cited by 105Neuroendocrine regulation and behaviorGrowth Hormone and Insulin-like Growth FactorsNeuropeptides and Animal Physiology

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Clearance Studies of Oxytocin in Humans Using Radioimmunoassay Measurements of the Hormone in Plasma and Urine*

AMICO, JANET A., ULBRECHT, JAN S., ROBINSON, ALAN G.·1987·The Journal of Clinical Endocrinology & Metabolism

DOI 10.1210/jcem-64-2-340

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Abstract

Synthetic oxytocin (OT) was infused iv in four men at 3 mU/min, and the rate was doubled every 90 min for a total of three infusion periods. The mean (+/- SEM) OT MCR was 16.4 +/- 1.7 ml/kg X min and was independent of the rate of infusion. A method for measuring OT in urine was developed using an octadecasilyl-silica column for extraction of the hormone. The extracted residue was reconstituted in potassium phosphate buffer, pH 7.4, for RIA. The minimum detectable level of OT in urine was 0.2 microU/ml (defined as a bound to free ratio of approximately 90%). The mean recovery of OT was 77 +/- 2%. The mean (+/- SEM) concentration of endogenous OT in urine was 10.2 +/- 1.4 microU/ml. Endogenous OT in urine eluted from a reverse phase high pressure liquid chromatography column as a single peak of OT immunoreactivity in the position of synthetic OT. Urinary OT excretion during infusion of synthetic OT was linearly correlated with plasma OT concentration whether calculated as microunits of urinary OT per mg creatinine (r = 0.89) or urinary OT per min (r = 0.93). Mean urinary fractional clearance of OT (OT clearance/creatinine clearance) was 3.6% renal clearance of OT (5.5 ml/min or 0.43% of MCR). Thus, OT MCR was constant over a wide range of physiological plasma OT levels and was similar to MCR in pregnant women studied previously in this laboratory. Less than 1% of OT was cleared in urine. This study defines the relationship between urinary and plasma OT during steady state infusion of physiological concentrations of the hormone and indicates that measurements of OT in urine by RIA may prove helpful for pharmacokinetic and physiological studies of OT-related events in humans.

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Hereditary Vasopressin Resistance in Man and Mouse
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Social correlates of variation in urinary oxytocin concentrations of mantled howler monkeys Alouatta palliata (Gray, 1849) (Primates: Atelidae): A preliminary assessment
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Validation of a Commercial Radioimmunoassay for Measurement of Human Peripheral OxytocinPreprint
Gerred, K., & Kapoor, A. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.22.533823 · Cited by 1
Cognitive, affective and social psychological correlates of psychopathic personality traits in offenders and non-offenders
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Rudzik, A. E. F. (2022) · ScholarWorks@UMassAmherst (University of Massachusetts Amherst) · doi:10.7275/1264520
Original Open Access
Tako, M., Shimabukuro, J., Jiang, W. J., Yamada, M., Ishida, H., & Kiso, M. (2013)
The role of oxytocin, testosterone and cortisol in affiliation and bonding in male Barbary macaqaues
Rincon, A. V. (2020) · eDiss (Georg-August-Universität Göttingen) · doi:10.53846/goediss-7818

Authors: AMICO, J. A., ULBRECHT, J. S., & ROBINSON, A. G.
Affiliations: University of Pittsburgh (US)
Venue: The Journal of Clinical Endocrinology & Metabolism
Publisher: The Endocrine Society
Published: 1987-02
Volume: 64
Issue: 2
Pages: 340-345
ISSN: 0021-972X (ISSN-L)
1945-7197
DOI: 10.1210/jcem-64-2-340
OpenAlex: W1969668906
Cited by: 105
References: 21
Citations by year: 2026: 2 · 2025: 4 · 2024: 3 · 2023: 3 · 2022: 7 · 2021: 4 · 2020: 5 · 2019: 9 · 2018: 10 · 2017: 4 · 2016: 6 · 2015: 7 · 2014: 7 · 2013: 5 · 2012: 5
FWCI: 2.03
Type: journal article
Language: en
Open access: closed
Locations: The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
PubMed (publishedVersion)
Funders: University of Pittsburgh
National Institutes of Health (5r01hd019787-03, 5r01am016166-12)
Eunice Kennedy Shriver National Institute of Child Health and Human Development (1R01-HD-19787)
Topics: Life Sciences › Neuroscience › Endocrine and Autonomic Systems › Neuroendocrine regulation and behavior
Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Growth Hormone and Insulin-like Growth Factors
Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuropeptides and Animal Physiology
Keywords: oxytocin, renal clearance, endogenous oxytocin, pharmacokinetics
MeSH terms: Adult, Chromatography, High Pressure Liquid, Humans, Male, Mathematics, Metabolic Clearance Rate, Oxytocin, Radioimmunoassay

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Clearance Studies of Oxytocin in Humans Using Radioimmunoassay Measurements of the Hormone in Plasma and Urine*

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