The DOI matches its Crossref record; 28 of the 28 references it cites were found in a registry or an index.
24-Hour Profiles of Adrenocorticotropin, Cortisol, and Growth Hormone in Major Depressive Illness: Effect of Antidepressant Treatment*
Abstract
Plasma ACTH, cortisol, and GH concentrations were measured at 15-min intervals for 24 h in 11 men suffering from major depressive illness during an acute episode of depression and during clinical remission following antidepressant treatment with either electroconvulsive therapy or amitriptyline. Seven age-matched normal men also were studied. During the acute phase of the illness, the patients had abnormally short rapid eye movement sleep latencies, hypercortisolism, early timing of the nadirs of the ACTH-cortisol rhythms, and shorter nocturnal periods of quiescent cortisol secretion. GH was hypersecreted during wakefulness, and a major pulse occurred before, rather than after, sleep onset. After treatment, rapid eye movement sleep latencies were lengthened, and cortisol levels returned to normal due to a decrease in the magnitude of episodic pulses. Moreover, the timing of the circadian rhythms of ACTH and cortisol as well as the duration of the quiescent period of cortisol secretion were normalized. The amount of GH secreted during wakefulness decreased to normal values, with fewer significant GH pulses. The major elevation of GH secretion in the early part of the night occurred later than that during the depressive episode. These results demonstrate that a disorder of circadian rhythmicity characterizes acute episodes of major depressive illness and that this chronobiological abnormality as well as the hypersecretion of ACTH, cortisol, and GH are state rather than trait dependent.
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Cites
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Cited by
David, D. J., Samuels, B. A., Rainer, Q., Wang, J.-W., Marsteller, D., Mendez, I., Drew, M., Craig, D. A., Guiard, B. P., Guilloux, J.-P., et al. (2009) · Neuron · doi:10.1016/j.neuron.2009.04.017 · Cited by 1,267
Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment
Pariante, C. M., & Miller, A. H. (2001) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01088-x · Cited by 1,147
The macrophage theory of depression
Smith, R. S. (1991) · Medical Hypotheses · doi:10.1016/0306-9877(91)90272-z · Cited by 931
Surget, A., Saxe, M., Leman, S., Ibarguen-Vargas, Y., Chalon, S., Griebel, G., Hen, R., & Belzung, C. (2008) · Biological Psychiatry · doi:10.1016/j.biopsych.2008.02.022 · Cited by 556
The Functional and Clinical Significance of the 24-Hour Rhythm of Circulating Glucocorticoids
Oster, H., Challet, E., Ott, V., Arvat, E., de Kloet, E. R., Dijk, D.-J., Lightman, S., Vgontzas, A., & Van Cauter, E. (2017) · Endocrine Reviews · doi:10.1210/er.2015-1080 · Cited by 548
“When a clinical remission of the depressed state is obtained, the hypercortisolism and the alterations in the quiescent period disappear, indicating that these disturbances are statedependent, rather than trait-dependent (376).”
Metadata
- Authors
- LINKOWSKI, P., MENDLEWICZ, J., KERKHOFS, M., LECLERCQ, R., GOLSTEIN, J., BRASSEUR, M., COPINSCHI, G., & CAUTER, E. V.
- Venue
- The Journal of Clinical Endocrinology & Metabolism
- Publisher
- The Endocrine Society
- Published
- 1987-07
- Volume
- 65
- Issue
- 1
- Pages
- 141-152
- ISSN
- 0021-972X (ISSN-L)
- 1945-7197
- OpenAlex
- W2079581208
- Cited by
- 320
- References
- 28
- FWCI
- 3.43
- Type
- journal article
- Language
- en
- Open access
- closed
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- LINKOWSKI, P., MENDLEWICZ, J., KERKHOFS, M., LECLERCQ, R., GOLSTEIN, J., BRASSEUR, M., COPINSCHI, G., & CAUTER, E. V. (1987). 24-Hour Profiles of Adrenocorticotropin, Cortisol, and Growth Hormone in Major Depressive Illness: Effect of Antidepressant Treatment*. The Journal of Clinical Endocrinology & Metabolism. https://doi.org/10.1210/jcem-65-1-141
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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