Relationship of Islet Function to Insulin Action in Human Obesity*

Glucose clamp technique: a method for quantifying insulin secretion and resistance.

DeFronzo, R. A., Tobin, J. D., & Andres, R. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.237.3.e214 · Cited by 7,425 · see citing works

Immunoassay of Insulin: Two Antibody System: Plasma Insulin Levels of Normal, Subdiabetic and Diabetic Rats

Morgan, C. R., & Lazarow, A. (1963) · Diabetes · doi:10.2337/diab.12.2.115 · Cited by 2,212 · see citing works

Relation of Body Fat Distribution to Metabolic Complications of Obesity*

KISSEBAH, A. H., VYDELINGUM, N., MURRAY, R., EVANS, D. J., KALKHOFF, R. K., & ADAMS, P. W. (1982) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-54-2-254 · Cited by 1,909 · see citing works

Quantitative estimation of insulin sensitivity.

Bergman, R. N., Ider, Y. Z., Bowden, C. R., & Cobelli, C. (1979) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1979.236.6.e667 · Cited by 1,874 · see citing works

Impact of obesity on metabolism in men and women. Importance of regional adipose tissue distribution.

Krotkiewski, M., Björntorp, P. A., Sjöström, L., & Smith, U. (1983) · Journal of Clinical Investigation · doi:10.1172/jci111040 · Cited by 1,448 · see citing works

The Degree of Masculine Differentiation of Obesities

Vague, J. (1956) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/4.1.20 · Cited by 1,417 · see citing works

Effects of arterial versus venous sampling on analysis of glucose kinetics in man

McGuire, E. A., Helderman, J. H., Tobin, J. D., Andres, R., & Berman, M. D. (1976) · Journal of Applied Physiology · doi:10.1152/jappl.1976.41.4.565 · Cited by 704 · see citing works

Excessive Insulin Response to Glucose in Obese Subjects as Measured by Immunochemical Assay

Karam, J. H., Grodsky, G. M., Forsham, P. H., & McWilliams, N. B. (1963) · Diabetes · doi:10.2337/diab.12.3.197 · Cited by 591 · see citing works

Endocrine and Metabolic Effects of Experimental Obesity in Man

Sims, E. A. H., Danforth, E., Horton, E. S., Bray, G. A., Glennon, J. A., & Salans, L. B. (1973) · Elsevier eBooks · doi:10.1016/b978-0-12-571129-6.50016-6 · Cited by 563 · see citing works

Diminished B cell secretory capacity in patients with noninsulin-dependent diabetes mellitus

Ward, W. K., Bolgiano, D. C., McKnight, B., Halter, J. B., & Porte, D. (1984) · Journal of Clinical Investigation · doi:10.1172/jci111542 · Cited by 483 · see citing works

Pathogenesis of Age-Related Glucose Intolerance in Man: Insulin Resistance and Decreased β-Cell Function*

CHEN, M., BERGMAN, R. N., PACINI, G., & PORTE, D. (1985) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-60-1-13 · Cited by 353 · see citing works

Plasma insulin responses to glucose and tolbutamide of normal weight and obese diabetic and nondiabetic subjects

Perley, M., & Kipnis, D. M. (1966) · Diabetes · doi:10.2337/diab.15.12.867 · Cited by 330 · see citing works

Lilly Lecture 1980: Insulin Resistance and Insulin Action: An In Vitro and In Vivo Perspective

Olefsky, J. M. (1981) · Diabetes · doi:10.2337/diab.30.2.148 · Cited by 315 · see citing works

Effects of long-term physical training on body fat, metabolism, and blood pressure in obesity

Krotkiewski, M., Mandroukas, K., Sjöström, L., Sullivan, L., Wetterqvist, H., & Björntorp, P. A. (1979) · Metabolism · doi:10.1016/0026-0495(79)90018-0 · Cited by 247 · see citing works

The Insulin Sensitivity Index in Nondiabetic Man: Correlation Between Clamp-derived and IVGTT-derived Values

Beard, J. C., Bergman, R. N., Ward, W. K., & Porte, D. (1986) · Diabetes · doi:10.2337/diab.35.3.362 · Cited by 247 · see citing works

The islands of langerhans in 19 cases of obesity

OGILVIE, R. F. (1933) · The Journal of Pathology and Bacteriology · doi:10.1002/path.1700370314 · Cited by 246 · see citing works

Insulin resistance and impaired insulin secretion in subjects with histories of gestational diabetes mellitus

Ward, W. K., Johnston, C. L. W., Beard, J. C., Benedetti, T. J., Halter, J. B., & Porte, D. (1985) · Diabetes · doi:10.2337/diab.34.9.861 · Cited by 159 · see citing works

Potentiation of Insulin Secretory Responses by Plasma Glucose Levels in Man: Evidence That Hyperglycemia in Diabetes Compensates for Impaired Glucose Potentiation*

Halter, J. B., Graf, R. J., & Porte, D. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-6-946 · Cited by 150 · see citing works

Familial diabetes mellitus in mice, associated with insulin resistance, obesity, and hyperplasia of the islands of langerhans.

Bleisch, V. R., Mayer, J., & Dickie, M. M. (2004) · PubMed · Cited by 149 · see citing works

Decreased Insulin Removal Contributes to Hyperinsulinemia in Obesity

FABER, O. K., Christensen, K. C., Kehlet, H., Madsbad, S., & Binder, C. (1981) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-53-3-618 · Cited by 148 · see citing works

Arginine-stimulated Acute Phase of Insulin and Glucagon Secretion: I. In Normal Man

Palmer, J. P., Walter, R. M., & Ensinck, J. W. (1975) · Diabetes · doi:10.2337/diab.24.8.735 · Cited by 120 · see citing works

Hyperinsulinemia of obesity is due to decreased clearance of insulin

Meistas, M. T., Margolis, S., & Kowarski, A. A. (1983) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1983.245.2.e155 · Cited by 116 · see citing works

Dexamethasone-induced insulin resistance enhances B cell responsiveness to glucose level in normal men

Beard, J. C., Halter, J. B., Best, J. D., Pfeifer, M. A., & Porte, D. (1984) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1984.247.5.e592 · Cited by 109 · see citing works

Obesity and diabetes mellitus with striking congenital hyperplasia of the islets of langerhans in spiny mice (Acomys Cahirinus)

Gonet, A. E., Stauffacher, W., PICTET, R. L., & Renold, A. E. (1966) · Diabetologia · doi:10.1007/bf01257907 · Cited by 102 · see citing works

Regional adipose tissue cellularity in relation to metabolism in young and middle-aged women

Krotkiewski, M., Sjöström, L., Björntorp, P. A., & Smith, U. (1975) · Metabolism · doi:10.1016/0026-0495(75)90038-4 · Cited by 87 · see citing works

Adaptation of B and A cell function during prolonged glucose infusion in human subjects

Ward, W. K., Halter, J. B., Beard, J. C., & Porte, D. (1984) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1984.246.5.e405 · Cited by 83 · see citing works

Metabolic Effects of Weight Loss in Obese Subjects: Changes in Plasma Substrate Levels, Insulin and Growth Hormone Responses

Kalkhoff, R. K., Kim, H. J., Cerletty, J. M., & Ferrou, C. A. (1971) · Diabetes · doi:10.2337/diab.20.2.83 · Cited by 79 · see citing works

Peripheral Hyperinsulinemia of Simple Obesity: Pancreatic Hypersecretion or Impaired Insulin Metabolism?*

Bonora, E., Zavaroni, I., Bruschi, F., Alpi, O., Pezzarossa, A., GUERRA, L., Dall’Aglio, E., Coscelli, C., & BUTTURINI, U. (1984) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-59-6-1121 · Cited by 68 · see citing works

THE RELATIONSHIP OF OBESITY AND GROWTH HORMONE TO SERUM INSULIN LEVELS*

Karam, J. H., Grodsky, G. M., & Forsham, P. H. (1965) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1965.tb34804.x · Cited by 57 · see citing works

Glucose kinetics in human obesity

Franckson, J. R. M., Malaise, W. J., Arnould, Y., Rasio, E., Ooms, H., BALASSE, E. O., Conard, V., & Bastenie, P. A. (1966) · Diabetologia · doi:10.1007/bf00423017 · Cited by 56 · see citing works

C-Peptide and Insulin Secretion in Pima Indians and Caucasians: Constant Fractional Hepatic Extraction over a Wide Range of Insulin Concentrations and in Obesity*

Savage, P. J., Flock, E. V., Mako, M. E., BLIX, P. M., Rubenstein, A. H., & BENNETT, P. H. (1979) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-48-4-594 · Cited by 56 · see citing works

Basal and stimulated hyperinsulinism: reversible metabolic sequelae of obesity.

Jd, B., Porte, D., Jd, B., & El, B. (1974) · PubMed · Cited by 37 · see citing works

“Staircase” Glucose Stimulation of Insulin Secretion in Obesity: Measure of Beta-cell Sensitivity and Capacity

Karam, J. H., Grodsky, G. M., Kn, C., Schmid, F. G., Burrill, K. C., & Forsham, P. H. (1974) · Diabetes · doi:10.2337/diab.23.9.763 · Cited by 31 · see citing works

The relative contributions of insulin resistance and beta-cell dysfunction to the pathophysiology of type 2 diabetes

Kahn, S. E. (2003) · Diabetologia · doi:10.1007/s00125-002-1009-0 · Cited by 2,166 · see citing works

The Importance of -Cell Failure in the Development and Progression of Type 2 Diabetes

Kahn, S. E. (2001) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.86.9.7713 · Cited by 694 · see citing works

Impaired Glucose Tolerance as a Disorder of Insulin Action

Lillioja, S., Mott, D. M., Howard, B. V., Bennett, P. H., Yki-Järvinen, H., Freymond, D., Nyomba, B. L., Zurlo, F., Swinburn, B., & Bogardus, C. (1988) · New England Journal of Medicine · doi:10.1056/nejm198805123181901 · Cited by 578 · see citing works

Evaluation of Simple Indices of Insulin Sensitivity and Insulin Secretion for Use in Epidemioiogic Studies

Hanson, R. L., Pratley, R. E., Bogardus, C., Narayan, K. M. V., Roumain, J. M. L., Imperatore, G., Fagot-Campagna, A., Pettitt, D. J., Bennett, P. H., & Knowler, W. C. (2000) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a010187 · Cited by 463 · see citing works

Endocrine disruptors in the etiology of type 2 diabetes mellitus

Alonso-Magdalena, P., Quesada, I., & Nadal, A. (2011) · Nature Reviews Endocrinology · doi:10.1038/nrendo.2011.56 · Cited by 404 · see citing works

Improving reproductive performance in overweight/obese women with effective weight management

Norman, R. J. (2004) · Human Reproduction Update · doi:10.1093/humupd/dmh018 · Cited by 378 · see citing works

Alpha cell function in health and disease: influence of glucagon-like peptide-1

Dunning, B. E., Foley, J. E., & Åhrén, B. (2005) · Diabetologia · doi:10.1007/s00125-005-1878-0 · Cited by 268 · see citing works

Obesity, Body Fat Distribution, Insulin Sensitivity and Islet β-Cell Function as Explanations for Metabolic Diversity

Kahn, S. E., Prigeon, R. L., Schwartz, R. S., Fujimoto, W. Y., Knopp, R. H., Brunzell, J. D., & Porte, D. (2001) · Journal of Nutrition · doi:10.1093/jn/131.2.354s · Cited by 236 · see citing works

Effect of exercise on insulin action, glucose tolerance, and insulin secretion in aging

Kahn, S. E., Larson, V., Beard, J. C., Cain, K. C., Fellingham, G. W., Schwartz, R. S., Veith, R. C., Stratton, J. R., Cerqueira, M., & Abrass, I. B. (1990) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1990.258.6.e937 · Cited by 198 · see citing works

Short-Term Treatment with Bisphenol-A Leads to Metabolic Abnormalities in Adult Male Mice

Batista, T. M., Alonso‐Magdalena, P., Vieira, E. C., do Amaral, M. E. C., Cederroth, C. R., Nef, S., Quesada, I., Carneiro, E. M., & Nadal, Á. (2012) · PLoS ONE · doi:10.1371/journal.pone.0033814 · Cited by 179 · see citing works

Pancreatic Beta-Cell Dysfunction as the Primary Genetic Lesion in NIDDM: Evidence From Studies in Normal Glucose-Tolerant Individuals With a First-Degree NIDDM Relative

Pimenta, W. (1995) · JAMA · doi:10.1001/jama.1995.03520470063033 · Cited by 174 · see citing works

Role of Oxidative Stress in Diabetic Cardiomyopathy

Geest, B. D., & Mishra, M. (2022) · Antioxidants · doi:10.3390/antiox11040784 · Cited by 170 · see citing works

Deterioration in Carbohydrate Metabolism and Lipoprotein Changes Induced by Modern, High Fat Diet in Pima Indians and Caucasians

Swinburn, B. A., Boyce, V., Bergman, R. N., Howard, B. V., & Bogardus, C. (1991) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-73-1-156 · Cited by 154 · see citing works

Long-term high-fat feeding leads to severe insulin resistance but not diabetes in Wistar rats

Chalkley, S. M., Hettiarachchi, M., Chisholm, D. J., & Kraegen, E. W. (2002) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00173.2001 · Cited by 140 · see citing works

Pancreatic beta-cell loss and preservation in type 2 diabetes

Buchanan, T. A. (2003) · Clinical Therapeutics · doi:10.1016/s0149-2918(03)80241-2 · Cited by 131 · see citing works

Co-existence of severe insulin resistance and hyperinsulinaemia in pre-adolescent obese children

Caprio, S., Bronson, M. L., Sherwin, R. S., Rife, F., & Tamborlane, W. V. (1996) · Diabetologia · doi:10.1007/s001250050603 · Cited by 122 · see citing works

Insulin secretion and action in patients with pancreatic cancer

Cersósimo, E., Pisters, P. W. T., Pesola, G. R., McDermott, K., Bajorunas, D. R., & Brennan, M. F. (1991) · Cancer · doi:10.1002/1097-0142(19910115)67:2 · Cited by 119 · see citing works

Endocrine Aspects of Obesity

Glass, A. R. (1989) · Medical Clinics of North America · doi:10.1016/s0025-7125(16)30696-4 · Cited by 118 · see citing works

Delayed Transcapillary Transport of Insulin to Muscle Interstitial Fluid in Obese Subjects

Sjöstrand, M., Gudbjörnsdottir, S., Holmäng, A., Lönn, L., Strindberg, L., & Lönnroth, P. (2002) · Diabetes · doi:10.2337/diabetes.51.9.2742 · Cited by 114 · see citing works

Hyperinsulinemia and Ovarian Hyperandrogenism: Cause and Effect

Barbieri, R. L., & Hornstein, M. D. (1988) · Endocrinology and Metabolism Clinics of North America · doi:10.1016/s0889-8529(18)30405-5 · Cited by 108 · see citing works

Impaired β-cell function and insulin sensitivity in Japanese subjects with normal glucose tolerance

Kuroe, A., Fukushima, M., Usami, M., Ikeda, M., Nakai, Y., Taniguchi, A., Matsuura, T., Suzuki, H., Kurose, T., Yasuda, K., et al. (2002) · Diabetes Research and Clinical Practice · doi:10.1016/s0168-8227(02)00177-8 · Cited by 100 · see citing works

Insulin resistance is a poor predictor of type 2 diabetes in individuals with no family history of disease.

Goldfine, A. B., Bouche, C., Parker, R. A., Kim, C., Kerivan, A., Soeldner, J. S., Martin, B. C., Warram, J. H., & Kahn, C. R. (2003) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0438009100 · Cited by 99 · see citing works

Characterization of alterations in glucose and insulin metabolism in Prader-Willi subjects

Schuster, D. P., Osei, K., & Zipf, W. B. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90181-x · Cited by 95 · see citing works

Current Status of Islet Cell Replacement and Regeneration Therapy

Halban, P. A., German, M. S., Kahn, S. E., & Weir, G. C. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1819 · Cited by 89 · see citing works

How to measure insulin action in vivo

Scheen, A. J., Paquot, N., Castillo, M. J., & Lefèbvre, P. J. (1994) · Diabetes/Metabolism Reviews · doi:10.1002/dmr.5610100206 · Cited by 89 · see citing works

The effect of puberty on insulin resistance in obese children

Pilia, S., Casini, M. R., Foschini, M. L., Minerba, L., Musiu, M. C., Marras, V., Civolani, P., & Loche, S. (2009) · Journal of Endocrinological Investigation · doi:10.1007/bf03346475 · Cited by 70 · see citing works

Initial Combination Therapy for Type 2 Diabetes Mellitus: Is It Ready for Prime Time?

Zinman, B. (2010) · The American Journal of Medicine · doi:10.1016/j.amjmed.2010.11.003 · Cited by 65 · see citing works

Spectrum of endocrine abnormalities associated with acanthosis nigricans

Matsuoka, L. Y., Wortsman, J., Gavin, J. R., & Goldman, J. (1987) · The American Journal of Medicine · doi:10.1016/0002-9343(87)90903-x · Cited by 54 · see citing works

Whole-Body Vibration Training Effect on Physical Performance and Obesity in Mice

Huang, C., Tseng, T.-L., Huang, W.-C., Chung, Y., Chuang, H.-L., & Wu, J. (2014) · International Journal of Medical Sciences · doi:10.7150/ijms.9975 · Cited by 51 · see citing works

Acute ω-3 Fatty Acid Enrichment Selectively Reverses High-Saturated Fat Feeding-Induced Insulin Hypersecretion But Does Not Improve Peripheral Insulin Resistance

Holness, M. J., Smith, N. D., Greenwood, G. K., & Sugden, M. C. (2004) · Diabetes · doi:10.2337/diabetes.53.2007.s166 · Cited by 51 · see citing works

Islet dysfunction in obese women with impaired glucose tolerance

Larsson, H., & Ahrén, B. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90227-9 · Cited by 44 · see citing works

Medicinal Plants and Phytochemicals Regulating Insulin Resistance and Glucose Homeostasis in Type 2 Diabetic Patients: A Clinical Review

Mahdavi, A., Bagherniya, M., Mirenayat, M. S., Atkin, S. L., & Sahebkar, A. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-3-030-64872-5_13 · Cited by 44 · see citing works

Peripheral Insulin Regulates a Broad Network of Gene Expression in Hypothalamus, Hippocampus, and Nucleus Accumbens

Cai, W., Zhang, X., Batista, T. M., García-Martín, R., Softic, S., Wang, G., Ramirez, A. K., Konishi, M., O'Neill, B. T., Kim, J. H., et al. (2021) · Diabetes · doi:10.2337/db20-1119 · Cited by 40 · see citing works

Molecular Concept of Diabetic Wound Healing: Effective Role of Herbal Remedies

Soliman, A. M., Teoh, S. L., Ghafar, N. A., & Das, S. (2018) · Mini-Reviews in Medicinal Chemistry · doi:10.2174/1389557518666181025155204 · Cited by 40 · see citing works

Defects inβ-Cell Function and Insulin Sensitivity in Normoglycemic Streptozocin-Treated Baboons: A Model of Preclinical Insulin-Dependent Diabetes*

McCulloch, D. K., Raghu, P., JOHNSTON, C., Klaff, L. J., Kahn, S. E., Beard, J. C., Ward, W. K., BENSON, E. A., Koerker, D. J., Bergman, R. N., et al. (1988) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem-67-4-785 · Cited by 40 · see citing works

The Minimal Model of Glucose Regulation: A Biography

Bergman, R. N. (2003) · Advances in experimental medicine and biology · doi:10.1007/978-1-4419-9019-8_1 · Cited by 39 · see citing works

Simple empirical assessment of Beta-cell function by a constant infusion of glucose test in normal and Type 2 (non-insulin-dependent) diabetic subjects

Lévy, J., Rudenski, A. S., Burnett, M. A., Knight, R., Matthews, D. R., & Turner, R. C. (1991) · Diabetologia · doi:10.1007/bf00403285 · Cited by 38 · see citing works

Effect of insulin resistance and hyperglycemia on proinsulin release in a primate model of diabetes mellitus

Kahn, S. E., McCulloch, D. K., Schwartz, M. W., Palmer, J., & Porte, D. (1992) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.74.1.1727820 · Cited by 37 · see citing works

The Changing Landscape of Type 2 Diabetes: The Role of Incretin-Based Therapies in Managed Care Outcomes

Triplitt, C. L., McGill, J. B., Porte, D., & Conner, C. S. (2007) · Journal of Managed Care Pharmacy · doi:10.18553/jmcp.2007.13.9-c.1 · Cited by 34 · see citing works

Clinical Characteristics of People with Newly Diagnosed Type 2 Diabetes between 2015 and 2016: Difference by Age and Body Mass Index

Ha, K. H., Park, C., Jeong, I., Kim, H. J., Kim, S. Y., Kim, W. J., Yoon, J. S., Kim, D. J., Kim, S., & Kim, S. (2018) · Diabetes & Metabolism Journal · doi:10.4093/dmj.2018.42.2.137 · Cited by 23 · see citing works

Insulin secretory capacity and the regulation of glucagon secretion in diabetic and non-diabetic alcoholic cirrhotic patients

Kurszynska, Y. T., Goulas, S., Wollen, N., & McIntyre, N. (1998) · Journal of Hepatology · doi:10.1016/0168-8278(88)80015-1 · Cited by 22 · see citing works

Reliability of error estimates from the minimal model: implications for measurements in physiological studies

Prigeon, R. L., Kahn, S. E., & Porte, D. (1994) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1994.266.2.e279 · Cited by 22 · see citing works

THERAPY OF ENDOCRINE DISEASE: Amylin and calcitonin – physiology and pharmacology

Mathiesen, D. S., Lund, A., Holst, J. J., Knop, F. K., Lutz, T. A., & Bagger, J. I. (2022) · European Journal of Endocrinology · doi:10.1530/eje-21-1261 · Cited by 21 · see citing works

Hyperinsulinemic obesity and carbohydrate addiction: the missing link is the carbohydrate frequency factor

Heller, R. F., & Heller, R. F. (1994) · Medical Hypotheses · doi:10.1016/0306-9877(94)90004-3 · Cited by 21 · see citing works

Peroxisome Proliferator-Activated Receptor-α Activation during Pregnancy Attenuates Glucose-Stimulated Insulin Hypersecretion in Vivo by Increasing Insulin Sensitivity, without Impairing Pregnancy-Induced Increases in β-Cell Glucose Sensing and Responsiveness

Sugden, M. C., Greenwood, G. K., Smith, N. D., & Holness, M. J. (2002) · Endocrinology · doi:10.1210/en.2002-220811 · Cited by 21 · see citing works

Insulin and non—insulin-dependent glucose disposal in middle-aged and young athletes versus sedentary men

Manetta, J., Brun, J. ‐., Callis, A., Mercier, J. G., & Prefaut, C. (2001) · Metabolism · doi:10.1053/meta.2001.20205 · Cited by 19 · see citing works

Weight Loss Improves β-Cell Function in People With Severe Obesity and Impaired Fasting Glucose: A Window of Opportunity

Rothberg, A. E., Herman, W. H., Wu, C.-Y., IglayReger, H. B., Horowitz, J. F., Burant, C., Gałecki, A. T., & Halter, J. B. (2019) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgz189 · Cited by 17 · see citing works

Islet Cannabinoid Receptors

Flores, L. E., Alzugaray, M. E., Cubilla, M. A., Raschia, M. A., Zotto, H. H. D., Román, C. L., Suburo, Á. M., & Gagliardino, J. J. (2013) · Pancreas · doi:10.1097/mpa.0b013e31828fd32d · Cited by 15 · see citing works

The plasma C-peptide and insulin responses to stimulation with intravenous glucagon and a mixed meal in well-controlled Type 2 (non-insulin-dependent) diabetes mellitus: dependency on acutely established hyperglycaemia

Gjessing, H. J., Reinholdt, B., & Pedersen, O. (1989) · Diabetologia · doi:10.1007/bf00297450 · Cited by 15 · see citing works

The effect of various blood glucose levels on post-glucagon C-peptide secretion in type 2 (non insulin-dependent) diabetes

Nosari, I., Lepore, G., Maglio, M. L., Cortinovis, F., & Pagani, G. A. (1992) · Journal of Endocrinological Investigation · doi:10.1007/bf03348682 · Cited by 14 · see citing works

In vivo β-cell function at the transition to early non-insulin-dependent diabetes mellitus

Swinburn, B. A., Gianchandani, R. Y., Saad, M. F., & Lillioja, S. (1995) · Metabolism · doi:10.1016/0026-0495(95)90189-2 · Cited by 14 · see citing works

Relationship between Insulin Resistance and Effect of Atorvastatin in Non-diabetic Subjects

Yoshitomi, Y., Ishii, T., Kaneki, M., Tsujibayashi, T., Sakurai, S.-I., Nagakura, C., & Miyauchi, A. (2005) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat.12.9 · Cited by 12 · see citing works

Hypoglycaemia from Islet Cell Hyperplasia and Nesidioblastosis in a Patient with Type 2 Diabetes Mellitus—A Case Report

Kon, Y. C., Loh, K. C., Chew, S. P., Wong, D. W. K., Yap, W., Lee, Y. S., & Low, C.-Y. (2000) · Annals of the Academy of Medicine Singapore · doi:10.47102/annals-acadmedsg.v29n5p682 · Cited by 11 · see citing works

Carbohydrate Metabolism

Halter, J. B. (1995) · Comprehensive physiology · doi:10.1002/cphy.cp110107 · Cited by 11 · see citing works

Insulin sensitivity and secretion in youth onset type 2 diabetes with and without visceral adiposity

Amutha, A., Ali, M. K., Ranjit Unnikrishnan, I., Anjana, R. M., Ranjani, H., Gokulakrishnan, K., Mohan, V., & Narayan, K. M. V. (2015) · Diabetes Research and Clinical Practice · doi:10.1016/j.diabres.2015.05.018 · Cited by 10 · see citing works

Stimulated C-Peptide and Glucose Levels as Metabolic Criteria to Use Insulin Treatment in Adult-Onset Type II Diabetes

Lee, A. S., Bray, G. A., & Morley, J. E. (1996) · Endocrine Practice · doi:10.4158/ep.2.3.183 · Cited by 8 · see citing works

Regulation of Insulin Secretion in Vivo

Vidal, J., & Kahn, S. E. (2001) · Endocrine updates · doi:10.1007/978-1-4615-1597-5_7 · Cited by 7 · see citing works

The Effect of Liver Disease on the Endocrine System

Kruszynska, Y. T., & Bouloux, P. M. (2007) · Wiley eBooks · doi:10.1002/9780470691861.ch21b · Cited by 7 · see citing works

Insulin and Glucagon Secretion in vivo and its Neural Control

Taborsky, G. J. (2001) · Comprehensive physiology · doi:10.1002/cphy.cp070206 · Cited by 7 · see citing works

Relationship Between Insulin Sensitivity and Hyperinsulinemia in Early Insulin Resistance is Sex-dependent

Blackwood, S. J., Tischer, D., Pontén, M., Moberg, M., & Katz, A. (2025) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/clinem/dgaf282 · Cited by 6 · see citing works

Introduction

Tobin, B. W., & Miller, G. D. (2001) · Journal of Nutrition · doi:10.1093/jn/131.2.333s · Cited by 6 · see citing works

Efecto de la edad y de la menopausia sobre la masa sea

Martín, A. P., Pereda, R. G., Díaz, J. S., Villavieja-Atance, L., Lanza, J. R. L., Dierssen‐Sotos, T., Alén, J. C., & Bernad, V. M. S. (2006) · Revista Española de Enfermedades Metabólicas Óseas · doi:10.1016/s1132-8460(06)75265-5 · Cited by 3 · see citing works

Obesity and the Risk for Diabetes

Gougeon, R. (2001) · Elsevier eBooks · doi:10.1016/b978-012193155-1/50029-5 · Cited by 2 · see citing works

Profactor-H (elevated circulating insulin): The link to health risk factors and diseases of civilization

Heller, R. F., & Heller, R. F. (1995) · Medical Hypotheses · doi:10.1016/0306-9877(95)90089-6 · Cited by 2 · see citing works

Beta Cell Function: A Useful Measure of Insulin Resistance in Adolescent with Polycystic Ovarian Disease

Irum, R., Qureshi, G., Dilawar, A., Khurshid, R., & Khawar, S. (2016) · Annals of King Edward Medical University · doi:10.21649/akemu.v22i3.1402 · Cited by 1 · see citing works

Diabetes

Bourey, R. E., Kaw, M., Lester, S. G., Ghanem, S. S., & Najjar, S. M. (2014) · CRC Press eBooks · doi:10.1201/b16783-4 · Cited by 1 · see citing works

Normal Insulin Secretion in Humans

Utzschneider, K. M., Porte, D., & Kahn, S. E. (2003) · Wiley eBooks · doi:10.1002/0470862092.d0205 · Cited by 1 · see citing works

Obesity and the Risk for Type 2 Diabetes

Gougeon, R. (2012) · Elsevier eBooks · doi:10.1016/b978-0-12-391884-0.00031-7

Estudio del factor de transcripción SREBP1 en estados de resistencia a insulina.

Miralles, S. V. (2007) · DIGITAL.CSIC (Spanish National Research Council (CSIC))

Enhanced insulin sensitivity mediated by adipose tissue browning perturbs islet morphology and hormone secretion in response to autonomic nervous activation in female mice

Omar, B. A., Reimer, M. K., Enerbäck, S., & Åhrén, B. (2015) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00296.2015

Inevitability of beta cell failure in type 2 diabetes

Siegmund, T., & Usadel, K.-H. (2001) · Current Opinion in Endocrinology & Diabetes · doi:10.1097/00060793-200108000-00005

The effect of L-triiodothyronine on oxidative metabolism of muscle, adipose tissue, and liver in genetically obese mice

Oh, S. S. (1993) · doi:10.31274/rtd-180813-13071

Daniel Porte Jr., 13 August 1931–13 May 2023

Kahn, S. E., Woods, S. C., Halter, J. B., Taborsky, G. J., & Schwartz, M. W. (2023) · Diabetes · doi:10.2337/db23-0787

Carbohydrate Metabolism

Halter, J. B. (1994) · Comprehensive physiology · doi:10.1002/j.2040-4603.1994.tb01679.x

Islet dysfunction in obese women with impaired glucose tolerance

Larsson, H., & Ahrén, B. (1996) · Metabolism · doi:10.1016/s0026-0495(96)90227-9 · Cited by 44 · see citing works

Quantification of the relationship between insulin sensitivity and β-cell function in human subjects: evidence for a hyperbolic function

Kahn, S. E., Prigeon, R. L., McCulloch, D. K., Boyko, E. J., Bergman, R. N., Schwartz, M. W., Neifing, J. L., Ward, W. K., Beard, J. C., & Palmer, J. P. (1993) · Diabetes · doi:10.2337/diab.42.11.1663 · Cited by 1,405 · see citing works

Beta-Cell Function in Obesity

Ferrannini, E., Camastra, S., Gastaldelli, A., Sironi, A. M., Natali, A., Muscelli, E., Mingrone, G., & Mari, A. (2004) · Diabetes · doi:10.2337/diabetes.53.suppl_3.s26 · Cited by 156 · see citing works

Analysis of the relationship between body mass index, insulin resistance, and beta-cell function: A cross-sectional study using the minimal model

Estévez, D. A. G., Araújo‐Vilar, D., Saavedra, Á., Fiestras-Janeiro, M. G., & Cabezas-Cerrato, J. (2004) · Metabolism · doi:10.1016/j.metabol.2004.06.014 · Cited by 40 · see citing works

Obesity Is Associated With Increased Basal and Postprandial β-Cell Insulin Secretion Even in the Absence of Insulin Resistance

van Vliet, S., Koh, H. E., Patterson, B. W., Yoshino, M., Laforest, R. A., Gropler, R. J., Klein, S., & Mittendorfer, B. (2020) · Diabetes · doi:10.2337/db20-0377 · Cited by 114 · see citing works