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Cited by 414Hormonal and reproductive studiesAdrenal Hormones and DisordersLipoproteins and Cardiovascular Health

The DOI matches its Crossref record; 16 of the 16 references it cites were found in a registry or an index.

Dehydroepiandrosterone reduces serum low density lipoprotein levels and body fat but does not alter insulin sensitivity in normal men.

NESTLER, JOHN E., BARLASCINI, CORNELIUS O., CLORE, JOHN N., BLACKARD, WILLIAM G.·1988·The Journal of Clinical Endocrinology & Metabolism
DOI 10.1210/jcem-66-1-57
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Abstract

To assess the effects of dehydroepiandrosterone (DHEA) on body fat mass, serum lipid levels, and tissue sensitivity to insulin, five normal men were given placebo and five normal men were given oral DHEA [1600 mg/day (554.7 mmol/day)] for 28 days in a randomized, double blind study. In the DHEA group serum DHEA-S levels rose 2.5- to 3.5-fold, and mean (+/- SEM) serum androstenedione rose from 4.3 +/- 0.6 to 8.6 +/- 1.2 nmol/L (P less than 0.004, by paired t test), but serum total testosterone, free testosterone, sex hormone-binding globulin, estradiol, and estrone levels did not change. In the DHEA group the mean percent body fat decreased by 31%, with no change in weight. This suggests that the reduction in fat mass was coupled with an increase in muscle mass. DHEA administration also resulted in a fall in mean serum total cholesterol concentration (4.82 +/- 0.21 vs. 4.48 +/- 0.29 nmol/L; P less than 0.05), which was due almost entirely to a fall of 7.5% in mean serum low density lipoprotein cholesterol (3.21 +/- 0.11 vs. 2.97 +/- 0.14 nmol/L; P less than 0.01). No changes in anthropometric parameters or serum lipid levels occurred in the placebo group. Tissue sensitivity to insulin, assessed by the hyperinsulinemic-euglycemic clamp technique, did not change in either the placebo or DHEA groups. These results suggest that in normal men DHEA administration reduces body fat, increases muscle mass, and reduces serum low density lipoprotein cholesterol levels. Tissue sensitivity to insulin was unaffected by short term DHEA administration.

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Crossref · 10.1210/jcem-66-1-57

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Metadata

Authors
NESTLER, J. E., BARLASCINI, C. O., CLORE, J. N., & BLACKARD, W. G.
Affiliations
Virginia Commonwealth University (US)
ORCID
BARLASCINI, CORNELIUS O.
Venue
The Journal of Clinical Endocrinology & Metabolism
Publisher
The Endocrine Society
Published
1988-01
Volume
66
Issue
1
Pages
57-61
ISSN
  • 0021-972X (ISSN-L)
  • 1945-7197
DOI
10.1210/jcem-66-1-57
OpenAlex
W2094493191
Cited by
414
References
16
Citations by year
2025: 1 · 2024: 1 · 2023: 1 · 2022: 2 · 2021: 3 · 2020: 1 · 2019: 6 · 2018: 5 · 2017: 6 · 2016: 6 · 2015: 2 · 2014: 9 · 2013: 5 · 2012: 8
FWCI
9.96
Type
journal article
Language
en
Open access
closed
Locations
  • The Journal of Clinical Endocrinology & Metabolism (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • University of Oregon
  • National Institutes of Health (5t32am007428-04)
  • National Center for Research Resources (RR 00065)
Topics
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Hormonal and reproductive studies
  • Health Sciences › Medicine › Endocrinology, Diabetes and Metabolism › Adrenal Hormones and Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Lipoproteins and Cardiovascular Health
Keywords
dehydroepiandrosterone, fat loss, LDL cholesterol, serum lipids, insulin sensitivity, androstenedione, DHEA sulfate, muscle mass, hyperinsulinemic-euglycemic clamp, testosterone, sex hormone-binding globulin, estradiol, healthy men
MeSH terms
Adipose Tissue, Adult, Androgens, Androstenedione, Body Composition, Cholesterol, Dehydroepiandrosterone, Humans, Insulin, Lipids, Lipoproteins, LDL, Cholesterol, LDL, Male, Muscles, Dehydroepiandrosterone Sulfate

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